摘要:

The fluoride concentration in urine is commonly used for monitoring fluoride exposure, e.g., in aluminium plants. Hitherto this parameter does not seem to have been related to the actual fluoride concentration in plasma following fluoride exposure. In the present study the fluoride concentration in urine, the urinary excretion rate of fluoride and the fluoride concentration in plasma have been studied in five volunteers after intake of JOmg of fluoride in the form of sodium fluoride (NaF) tablets. In pharmacokinetic analyses of the data calculation of the half-life of fluoride from plasma data and from the urinary excretion rate yielded almost identical results; 5.78 hours (plasma) and 5.11 hours (urine). It was found that plasma fluoride levels were correlated with the fluoride concentration in urine (r =. 7532; n=70), but even more with the urinary excretion rate of fluoride (r=.9651; n=63). The data suggest that plasma fluoride levels or urinary excretion rates of fluoride may give a more correct picture of occupational fluoride exposure than fluoride concentrations in urine.

ISSN:0096-1736    

出版商:OVID    

年代:1983

数据来源: OVID

摘要:

All cases of malignant mesothelioma (201) and other primary malignant pleural tumors (19) reported to the Connecticut Tumor Registry from 1955 through 1977 were studied in an attempt to identify high-risk jobs, industries and geographic locations and to estimate the risk attributable to asbestos exposure in the workplace. Data were obtained from hospital records, death certificates and city directories for cases, case spouses and a random sample (604) of Connect/cut decedents (1955-1975). Three cases involved histories of work in asbestos products manufacture, but there was no evidence of residential risk in that geographic area. Relative risk (RR) for carpenters and cabinetmakers was 2.25 (p<. 05); for plumbers and pipefitters, 3.87 (p<.05); and for persons "ever employed" in the rubber industry, 5.08 (p<.01). Occupational exposure was indicated in 85% of the cases; attributable risk (A R) was 36%. Risk increased with greater exposure and older age. AR was 81% in men aged 70 to 89 years at diagnosis. Reduction of unnecessary occupational asbestos exposure remains the highest public health priority.

ISSN:0096-1736    

出版商:OVID    

年代:1983

数据来源: OVID

ISSN:0096-1736    

出版商:OVID    

年代:1983

数据来源: OVID

摘要:

The mortality pattern of 2,157 female registered nurses was analyzed for the period 1963 through 1977 using death certificate data. Proportional mortality analysis was used to compare mortality among nurses with that of control groups derived from a population of other female workers. Results indicate an elevated risk of death from suicide among registered nurses.

ISSN:0096-1736    

出版商:OVID    

年代:1983

数据来源: OVID

摘要:

The mortality experience of 342 employees assigned to three aromatic amine-based dye production areas was examined in relation to duration of employment and interval since entry into these areas. No deaths due to bladder cancer were observed, and no statistically significant increases in mortality by work area or duration of exposure within work area were found, based on comparison with the mortality experience of the U.S. white male population. There were incidental findings of more digestive malignancies than expected in one production area, and more digestive and respiratory malignancies than expected in a second area; none of these were statistically significant. Because the digestive malignancies were not site-specific, and because similarities in specific job assignments were lacking for both digestive and respiratory malignancies, it is unlikely that these findings were work related. Nonetheless, in subsequent assessments of the present cohort and other populations exposed to similar materials an effort should be made to evaluate the occurrence of digestive and respiratory malignancies.

ISSN:0096-1736    

出版商:OVID    

年代:1983

数据来源: OVID

ISSN:0096-1736    

出版商:OVID    

年代:1983

数据来源: OVID

ISSN:0096-1736    

出版商:OVID    

年代:1983

数据来源: OVID

ISSN:0096-1736    

出版商:OVID    

年代:1983

数据来源: OVID

ISSN:0096-1736    

出版商:OVID    

年代:1983

数据来源: OVID