摘要:

Cysts located in the maxilla between the roots of an erupted lateral incisor and a canine were studied. Radicular cysts were excluded by the prerequisite of a positive pulp vitality test in both adjacent teeth, and odontogenic keratocysts were excluded by histologic examination. In the period from 1971–1987, 8 cysts were found which fulfilled the criteria for inclusion. The average age of the patients was 18.8 yr. All cysts were lined by a hyperplastic non‐keratinized stratified squamous epithelium and there was always a heavy infiltrate of inflammatory cells in the connective tissue. The clinical and histologic features were similar to those previously reported for inflammatory paradental cysts (IPC) in the mandible. Therefore, it seems justified to suggest that some of the previously described globulomaxillary cysts are in fact I

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1989.tb00749.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

The present investigation concerns 113 patients with peripheral giant cell granulomas, 52 patients with central giant cell granulomas and 18 patients with non‐ossifying fibromas of the long bones. The purpose was to analyze the possible equivalence of central giant cell granulomas with non‐ossifying fibromas. Non‐ossifying fibromas occur at a lower mean age than central giant cell granulomas and moreover, although central giant cell granulomas may exhibit areas that are histologically similar to non‐ossifying fibromas, the presence of other features, especially bone formation, warrants a recognition of central giant cell granulomas and non‐ossifying fibromas as separate

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1989.tb00750.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

The Coexpression of keratin and vimentin is described in 45 pleomorphic adenomas using an immunoperoxidase MAb method. Histopathologically, the outer layer of tubuloductal structures and peripheral tumor cells in solid masses, including modified or neoplastic myoepithelial cells, showed positive staining with monoclonal keratin antibody K8.12 and vimentin. This staining was found in the ratio of 10/26 (38.5%) in tubuloductal structures, 2/7 (28.6%) in peripheral tumor cells and 8/12 (66.7%) in modified myoepithelial cells. Concomitant staining of other keratin antibodies (PKK1, KL1) and vimentin did not exist. In addition, the ductal basal cells of normal salivary glands showed positive K8.12 labelling. The histogenesis of pleomorphic adenoma is discussed in relation to the differentiation of either ductal basal cells or ductal luminal cells from a single stem cell origin or the direct transformation of ductal basal cells to outer tumor cells and/or modified myoepithelial cells, both coexpressing K8.12 and vimentin.

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1989.tb00751.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

The aim of the present study was to use scanning electron microscopy (SEM) to visualize the morphology of the enamel surface in 12 primary teeth from children with amelogenesis imperfecta (AI). The observations were correlated to genetic, clinical and microradiographic data from the same teeth and to non‐affected control teeth. SEM showed similar disturbances in teeth with a clinical predominance of hypoplasias and in teeth with a predominance of hypomineralization. In the microradiographs the enamel of most teeth showed both hypoplasias and areas of hypomineralization, independently of the predominant clinical manifestation. In the one boy with an X‐linked inheritance pattern, both SEM and microradiography showed the morphology of the enamel to be unique in the present study. In the other teeth, similar manifestations were found in cases with AI as an AD trait and in the sporadic ca

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1989.tb00752.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

The histopathology of human root caries was examined in extracted teeth by different optical methods. The present part of the study details the sequential stages of initial caries in both cementum and peripheral dentin. Significant differences are shown between the mechanisms operating on the various dental hard tissues during development of caries. Histologically distinguishable reaction patterns depended on both the degree of the cariogenic challenge and the respective structural features of cementum and peripheral dentin. Earliest lesions, histologically visible as small clefts traversing cementum and extending into peripheral dentin, were clinically not detectable. Cementum was stepwise destroyed until peripheral dentin became exposed. The exposed peripheral dentin was sclerosed and tubule‐free. Demineralization of dentin preceded the degradation of the organic matrix. Frequently, a hypermineralized layer occurred in both cementum and exposed dentin. Its localization was not identical with the anatomical surface. Initial penetration of bacteria into peripheral dentin occurred along small clefts. Breakdown of the organic matrix was the final step in the destructive phase of the carious proces

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1989.tb00753.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

Osteopetrosis, a general increase in bone density, is well‐known as an autosomal recessive disease in several mammalian species. Compared with normal littermates, the osteopetrotic rats suffered from a complete failure of tooth eruption. Histologic and microradiographic studies show that the molars and the incisors developed a progressive ankylosis, the bone invades the germs and finally dissociates them. As early as the first days after birth, the incisors and the first molars are affected by the osteopetrotic process while the second and the third molars remain untouched. The periodontal membrane of the incisors is rapidly invaded by the osteopetrotic bone trabeculae. After the eleventh day, the process reached all molars. The germs were overlaid by an occlusal unresorbed bone. The formation of the gebernacular canal appeared to be independent of the prefunctional eruptio

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1989.tb00754.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

The osteopetroticop/oprats suffered from a complete failure of tooth eruption in association with a reduced bone resorption. An unresorbed occlusal bone overlaid the germs which remained embedded in bone. The process of prefunctional eruption in limited growing teeth depends on the resorption of the alveolar bone covering the germs. The aim of this study was to investigate the effects of hematopoietic grafts in newbornop/oprats on the process of prefunctional eruption. Fifteenop/optreated rats were used for radiographic, microradiographic and histologic examinations. After transfusion of bone marrow cells, we observed the restoration of bone resorption and a delayed eruption of the molars. The incisors never erupted. They developed odontome‐like tumors near their apices. These results confirm the dependence of tooth eruption on bone resorptio

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1989.tb00755.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

Irradiation mucositis is defined as an inflammatory‐like process of the oropharyngeal mucosa following therapeutic irradiation of patients who have head and neck cancer. Clinically, it is a serious side effect because severe mucositis can cause generalized problems (weight loss, nasogastric tube feedings) and interferes with the well‐being of the patient seriously. Grading mucositis is important for the evaluation of preventive and therapeutic measures. The object of this study was to develop a scoring method based on local mucositis signs only. Four clinical local signs of mucositis were used in this score: white discoloration, erythema, pseudomembranes and ulceration. Mucositis of the oral cavity was calculated during conventional irradiation protocol for 8 distinguishable areas using the 4 signs and their extent. A prospective evaluation of this method in 15 irradiated head and neck cancer patients displayed an S‐curve reflecting a symptomless first irradiation week, followed by a rapid and steady increase of white discoloration, erythema and pseudomembranes during the second and third week. Oral candidiasis, generalized symptoms such as weight loss and the highest mucositis scores were seen after 3 weeks irradiation. The novel mucositis scoring method may be of value in studying the effect of hygiene programs, topical application of disinfectans or antibiotics on oral muco

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1989.tb00756.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

Five focal epithelial hyperplasia (FEH) specimens from four patients were examined by Southern blot hybridization analysis to determine the specific human papillomavirus (HPV) types present. The histomorphologic features of these specimens were also evaluated and a broad variety of changes including koilocytes, mitosoid cells, ballooning cells and cells showing individual cell keratinization were noted. FEH lesions from the three patients sharing a familial relationship demonstrated HPV DNA sequences that were either the prototype HPV‐13 or a very closely related HPV‐13 subtype. These patients also showed similar clinical features. Lesional tissue from the other patient was found to harbor HPV DNA sequences similar to HPV‐32. In view of these findings it is suggested that these specific HPV types are associated with the characteristic FEH histomorphology desc

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1989.tb00757.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

The expression of the Class II major histocompatibility antigen HLA‐DR was quantified in the epithelial cells of labial salivary glands from patients with Sjögrens Syndrome (SS) and compared with similar expression in glands showing non‐specific sialadenitis and normal controls. In all glands more duct cells were positive than acinar cells but only in sialadenitis and SS was strong epithelial staining seen. The proportions of duct and acinar cells expressing HLA‐DR were increased between normals and sialadenitis (P<0.01) and between sialadenitis and SS (P<0.001). However, for all cases increased expression of HLA‐DR correlated to the increased proportion of inflammatory cells in the gland (P<0.01). The results indicate that although HLA‐DR is expressed on the epithelial cells in the glandular lesions of SS, this is not specific as it is also seen in sialadenitis. This supports the view that such expression is secondary to an inflammatory infiltrate and may not be of importance in initiating autoimmune tis

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1989.tb00758.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY