摘要:

An animal model has been developed in which implantation cysts have been produced very close to developing teeth within the jaws of Vervet monkeys. Various deciduous teeth were extracted from both the maxilla and the mandible of 6 young Vervel monkeys. After 4 weeks, full thickness mucoperiosteal flaps were raised in these areas, up to 6 recipient sites were prepared in each monkey by drilling holes in the alveolar bone and small pieces of autogenous palatal mucosa were placed in these graft recipient sites. One monkey was killed after 5, 8, 22 and 25 weeks respectively and 2 after 52 weeks. Of the 33 implants placed, cyst formation occurred from 11 (33%). The distribution of the cysts was irregular in that 4 cysts were produced in each of 2 animals while no cysts were found in another 2 animals. The cysts produced were filled with keratin and lined partly by a thick keratinising epithelium and partly by a thin non‐keratinising epithelium only a few cell layers thick. In one of the animals killed after 52 weeks, (he follicle of an erupting premolar tooth had collided with one of the cysts resulting in the cyst lining becoming incorporated into the follicle, partly replacing the follicular reduced enamel epithelium and forming now an integral part of the follicle. This observation supports the hypothesis that the follicular odontogenic keratocyst has an extra‐follicular origin arising alter the eruption of a tooth into a pre‐existing cyst c

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1987.tb00686.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

A monoclonal rheumatoid factor binding assay has been employed to detect IgG type immune complexes in sera from 21 patients with minor recurrent aphthous ulceration and 31 control subjects. In only one of the ulcer group patients was there a marginal elevation of immune complexes above the normal range, with no statistically significant difference between the patient and control groups. Assays of intrinsic serum rheumatoid factor and serum IgG, IgM and IgA levels also showed no significant differences between patient and control groups, with all mean values falling within the normal ranges.

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1987.tb00687.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

Granulocytic sarcomas arc malignant solid tumors composed of poorly differentiated myeloid cells that occur in association with myelocytic leukemia. The clinicopathologic characteristics of granulocytic sarcomas that presented in the oral mucosa and in the facial, scalp and neck skin of 8 patients in the acute phase of myelocytic leukemia are described and discussed. Although most of the tumors were demonstrably sensitive to cytosine arabinoside, alone or in combination with other antineoplastic drugs, the prognostic portent of these lesions was extremely poor.

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1987.tb00688.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

Using monoclonal antibodies reactive with Langerhans' cells (LCs), macrophages, and T cell subpopulations, the density and proportions of cells of the immune system of the normal oral mucosa were determined immunohistochemically, and compared with findings in oral squamous cell carcinomas (SCC) and basal cell epitheliomas (BCE). In normal oral epithelia, the dominant cell type was the LC, positive for CD 1, and expressing HLA‐DR antigens (DR+). Many intraepithelial cells were lymphocytes of the suppressor/cytotoxic phenotype (CD 8+), which was also the most prominent cell type in the normal mueosal slroma. Significant differences were observed for the content of CD 8‐, OKM 1‐, and CD 4‐positive cells in the epithelium of normal oral mucosa, SCC, and BCE, and for the amount of CD 1‐positive Langerhans cells in the connective tissue of the different groups of tissues. When CD 4/CD 8 ratios were calculated, differences between SCC and BCE became most evident. A CD 4/CD 8 ratio greater 0.5 was seen to be characteristic for BCE. Thus, in contrast to the striking preponderance of suppressor/cytotoxic lymphocytes (CD 8+) in SCC, BCE showed typically almost balanced numbers of suppressor/cytotoxic (CD 8+) and helper/induced (CD 4+) lymphocytes. This finding further underlines the biological differences recognized between these most common neoplasias of the head

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1987.tb00689.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

This study was designed to evaluate the role that cholesterol, and the more hydrophilic ester, cholesterol hemisuccinate (CHS) have on the ability of epithelial cells to attach, spread and reorganize microtubule skeletons on a defined substratum. A431 carcinoma cells were grown and incubated with cholesterol, or CHS in polyvinyl pyrrolidone. Subsequently the cells were plated either on plastic petri dishes or plasticware coated with collagen IV or laminin. The alteration in apparent membrane microviscosity was ascertained using fluorescence polarization measurements. Organization of microbutules was determined by immunofluroescence, and by transmission electron microscopy. Cholesterol and CHS inhibited attachment and spreading of epithelial cells. Cells previously attached and spread became spherical after treatment with cholesterol and CHS, but microtubules were unaffected. However, when the cells were pretreated in suspension with cholesterol or CHS the membrane micro viscosities markedly increased, and upon subsequent plating those cells adhering neither spread nor organized microtubule skeletons. These results suggest that cholesterol‐induced changes in lipid microviscosity modulate the membrane dynamics that control the ability of epithelial cells to attach, spread and organize microtubule skeleton

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1987.tb00690.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

164 odontogenic keratocysts from 60 patients with the basal cell naevus syndrome were compared with a similar number of single keratocysts matched for age and site. Significant differences between the two groups were found in the numbers of satellite cysts, solid islands of epithelial proliferation and odontogenic rests within the capsule, and in the numbers of mitotic figures in the epithelium lining the main cavity. An index of activity derived from these parameters suggests a greater growth potential in syndrome cysts; in addition, the patterns of association of the features support the theory that the odontogenic rests give rise to satellite cysts.

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1987.tb00691.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

We have reported that there is a difference in the variation of the nuclear DNA content of tumor cells among cases of squamous cell carcinoma induced by 9,10‐dimelhyl‐1,2‐benzanlhracenc (DMBA) in the rat submandibular gland. In the present investigation, the relationship between the nuclear DNA content of tumor cells in autotransplanted sections collected from primary lesions of DMBA‐induced tumors and their proliferative ability in the subfascial area of the rat abdomen was examined. As a result of autotransplantation, proliferation in the autotransplanted area was observed in 6 of 14 (42.8%) cases of autotransplantation. Five of these had a keratinizing squamous cell carcinoma while the remaining one had a sareomatoid tumor. The histological type of the tumor of the proliferative lesion in the transplanted area was very similar to that of the tumor tissues in the primary lesion or the transplanted section collected from the primary lesions. In the proliferative group, marked variation of the nuclear DNA content was observed in the tumor cells of the transplanted section. The proliferative index (PI) was high for these tumor cells in this group. There was no variation in the nuclear DNA content in the tumor cells of the nonproliferative group, and the PI was also low. These results were considered to suggest that there was a correlation between the nuclear DNA content of these experimental tumor cell and their proliferative ability in the autotransplanted area. Therefore, the determination of nuclear DNA content by this method can be used as an objective index of the proliferative ability of tumor

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1987.tb00692.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

In order to examine the behavior ofCandida albicansin an oral mucosal model, 16 isolates of the organism were collected from a variety of clinical settings and were inoculated weekly, in equal numbers and concentrations, into the mouths of separate groups of 20 female Sprague‐Dawley rats. Oral swabs were taken bi‐weekly in order to monitor the presence of the yeast. After 16 weeks, the animals were killed and the tongues were examined grossly and histologically. Six isolates demonstrated the ability to produce characteristic dorsal tongue lesions to varying degrees (1/20; 1/20; 1/20; 2/20; 3/20; and 12/20). Of the remaining 10 isolates, 5 showed hyphal penetration of the keratin layer of the dorsal tongue epithelium, yet no mucosal reaction was elicited and no lesion was produced (1/19; 2/19; 4/20; 5/20 and 5/20). These findings support the concept thatC. albicansexhibits a spectrum of mucosal pathogenicity for dorsal rat ton

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1987.tb00693.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

摘要:

Book reviewed in this articles:Apropriate use of fluorides for human health.Murray JJ. GenevaOral histology. Cell structure and function.Davis WLToxicity testing of dental materials.Stanley H. Boca Raton

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1987.tb00694.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1987.tb00695.x

出版商:Blackwell Publishing Ltd    

年代:1987

数据来源: WILEY