摘要:

In an attempt to extend and update information relating to oral cancer in Australia and to provide a basis for international comparison a group of 244 patients suffering from oral cancer have been studied in detail. These patients were all diagnosed in one Oral Pathology Biopsy Service used almost exclusively by oral surgeons and dentists, and although this introduced bias into the sample it had the advantage of standardising documentation. The male: female ratio (1.3 : 1) of patients with oral cancer was lower than that previously reported in Australia, but the average age of patients (60 years) was comparable with many previous reports. The floor of the mouth was the most common site of cancer. There was a significant over‐representation of tobacco and alcohol consumers amongst the patients, but a group of elderly females who had never used tobacco or alcohol, yet developed oral cancer, was identified. It was of particular interest that these elderly females had significantly lower haemoglobin and serum iron levels than a sex‐ and age‐matched control

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1984.tb01447.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

Eosinophilic granuloma has traditionally been designated as the least severe component of the inter‐related triad of diseases, Histiocylosis X (Lichtenstein 1953, 1964). In 1969, Lieberman and his group questioned the use of this time‐honored term and proposed instead that eosinophilic grunuloma be regarded as a separate and distinct entity which could present either as a singular (unifocal) lesion or as a multifocal process. The term, “multifocal eosinophilic granuloma” was, thus, suggested as a replacement for the designation formerly known as Hand‐Schuller‐Christian Disease. The remaining component of Histiooytosis X termed Letterer‐Siwe Disease was felt to be a totally separate disorder unrelated to eosinophilic granuloma and best classified as a relatively aggressive reticuloendothelial malignancy. In this presentation, we wish to report a case of multifocal eosinophilic granuloma which has run a very interesting course over a total of almost 10 years from the time of initial symptoms to the present. The more recent classification of Lieberman will be employed throughout this presentation. We will also propose the hypothesis that in this case, multifocal eosinophilic granuloma may represent a sequela of acquired immune deficiency perhaps initialed by T‐cell viral infection. The possibility that, in a susceptible host, development of eosinophilic granuloma may be triggered by contact with environmental agents will al

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1984.tb01448.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

An extrapulmonary oat‐cell carcinoma arose in the tongue of a 62‐year‐old man who had a long history of cigarette smoking and ethanol ingestion. At presentation, he had the primary tongue lesion and cervical lymph‐node metastases only, and search for a pulmonary primary was negative. Ten months later he died with metastases to liver, cerebrum, ribs, vertebrae, calvarium, and clavicle. Electron microscopy demonstrated cells with cytoplasmic processes and many dense‐core neurosecretory granules that had a tendency to concentrate in the processes. Cells were linked by desmosomes. Electron microscopy is necessary for definitive diagnosis of extrapulmonary oat‐cell

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1984.tb01449.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

Gels of crude gelatin were dialyzed to eliminate fluoride, and then acidified with 75 mM lactic and 25 mM acetic acid at pH 4.2 and interfaced with enamel and root surfaces in gel‐surface ratio of 0.2 ml/0.15 cm2. Enamel and root surface to gel mineral flux was reduced by initial inclusion of 0.5 and 1.0 mM fluoride with 2.5 mM calcium and 1.5 mM phosphate in gels at pH 4.2. Inclusion of 0.25 mM fluoride in the gels without added mineral ions had no effect in the first 22‐day interface. The 0.25, 0.5 and 1.0 mM fluoride remarkably increased remineralization in a second 12‐day interface. This indicated that the first fluoride exposure initiated formation of fluorapalites in the enamel which required a lower degree of gel saturation for enhanced remineralization in the second acid exposure. Fluoride had the same effect, but greater effectiveness on enamel than root‐surface remineralization. Gels of crude gelatin may contain sufficient mineral ions to alter remineralization‐demineralization of enamel and roo

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1984.tb01450.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

Complex carbohydrates in premalignant lesions of mouse submandibular gland tumors were examined by the lectin‐peroxidase conjugate method. Peroxidase‐conjugated lectins of PNA, RCA‐1, DBA, SBA, UEA‐1 and WGA were used to detect specific sugar residues of complex carbohydrates in premalignant lesions during experimental carcinogenesis. Marked reduction of PNA and SBA bindings occurred in duct‐like structures and cystic lesions which were transformed from granular convoluted tubule cells. Premalignant lesions bound slightly to PNA, RCA‐1, DBA, SBA and WGA and manifested increased UEA‐1 binding. Squamous metaplastic epithelia of premalignant lesions manifested increased binding to PNA, RCA‐1 and SBA as compared to those of duct‐like structure and

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1984.tb01451.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

In order to demonstrate Langerhans' cells in epithelium of oral lichen planus, monoclonal antibodies were used as immunological markers in combination with immunohistochemistry. By the use of anti‐Ia antibodies the Langerhans' cells were shown to express an increased number of Ia‐like antigens in comparison to the amounts found in healthy oral mucosa. The subepithelial infiltrate of mononuclear cells expressed identical Ia‐like antigens on their surfaces. With anti‐T6 antibodies as immunological markers, the number of Langerhans' cells was found to be virtually identical in diseased and healthy epithelium. Treatment of oral lichen planus with tretinoin resulted in a decrease of epithelial Ia‐like antigens compared with the number found in untreated lesions. However, treatment with tretinoin did not alter the frequency of Langerhans' cell marked with anti‐T6 antibodies. The present data demonstrate an increased amount of la‐like antigens per number of T6‐positive Langerhans' cells in diseased oral mucosa compared to healthy conditions. The increased expression of Ia‐like antigens on Langerhans' cells and the contemporary finding of Ia‐like antigens on the subepithelial T‐cells support the opinion that the pathogenesis of oral lichen planus is mainly a cell‐mediated type of

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1984.tb01452.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

The distribution of carcinoembryonic antigen (CEA), secretory component (SC), immunoglobulin A (IgA), immunoglobulin M (IgM), J‐chain, and lysozyme in tumors of minor salivary glands was investigated using an immunoperoxidase method. Although CEA was demonstrated in both benign and malignant tumors, its distribution was relatively more common and with increased staining intensity in malignant tissues. In pleomorphic adenomas, the distribution of SC was similar to that of IgA and J‐chain, suggesting the presence of secretory IgA in the epithelial cells. However, some neoplastic epithelial cells contained SC but not IgA and J‐chain. No IgM was detected in such cells. Lysozyme could be demonstrated only in pleomorphic adenomas. Mucocpidermoid tumors and adenoidcystic carcinomas were negative for lysozyme. These findings suggest that some neoplastic ductal epithelial cells of pleomorphic adenomas retain functional characteristics of normal epithelial

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1984.tb01453.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

Fluoride is widely used for the prevention of dental caries. Very low concentrations of fluoride are routinely ingested in optimally fluoridated drinking water of many communities. Higher concentrations of fluoride in toothpastes, mouthrinses and topically applied gels also may be ingested, especially by children. The potential effect of ingested fluoride on the gastric mucosa was the subject of this investigation. Solutions of 0, 1, or 10 mM NaF in 0.1 N HCl were placed in rat stomachs in vivo for up to one hour. The effects of fluoride on the structure and function of the gastric mucosa were determined. Histologic and SEM examinations revealed dose‐and time‐dependent damage to the surface mucous cells. The 10 mM, but not the 1 mM, NaF solution increased gastric mucosal permeability to small but not to large molecu

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1984.tb01454.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

Warty dyskeratoma (WD) is a benign solitary lesion of unknown aetiology affecting the skin and oral mucosa. The profound dyskeratotic changes may mimic invasive squamous cell carcinoma. Two cases of oral WD, which were originally diagnosed as early squamous cell carcinoma, arc presented. The clinical features, histopathology and aetiology are reviewed together with other reports in the literature. These 2 cases have been followed for 14 and 6 years respectively and they are the longest follow‐up periods reported in the literature in English. The lesions have not recurre

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1984.tb01455.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1984.tb01457.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY