ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1978.tb01600.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1978.tb01601.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

AbstractThe clinical signs, laboratory data, and histological features of recurrent aphthous ulcers (RAU) and Behçet's syndrome suggest a viral etiology. In fact, there are reports of adenovirus isolations in herpetiform oral ulcers and on the isolation of a filterable agent in sporadic cases of Behçet's syndrome. However, isolation studies on the major and minor aphthous ulcers and more recent studies on Behçet's syndrome have been negative. A review of the literature on the role of viruses and autoimmunity in RAU and Behçet's syndrome is presented.Biopsy specimens of ulcerative lesions were grownin vitrofor up to 300 days. Those cultures, along with leukocytes and body fluids, were examined by a variety of techniques for the presence of virus or viral antigens. Although a persistent or latent virus was not detected, these negative studies cannot exclude a viral etiology. In fact, the hypothesis of an infectious and viral etiology is still reasona

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1978.tb01602.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

AbstractThe oral lesions of five viral diseases of cattle are compared.Two of the diseases, foot‐and‐mouth disease and vesicular stomatitis, cause vesicles, and rinderpest, bovine virus diarrhea and malignant catarrhal fever produce sharply demarcated erosive lesions. Gross lesions of different diseases appear similar: however, histologically, there are subtle differences in the development of the lesi

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1978.tb01603.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

AbstractAn attempt is made to derive clues as to the etiology of aphthous stomatitis and Behçet's syndrome from analysis of the mode of action of the various therapeutic agents which have been employed in these diseases. It is concluded that owing to the diverse and frequently contrasting modes of action of these agents, this may well be an unproductive task. There is one exception to this conclusion. Since levamisole in small concentrations given intermittently appears to act as an immunopotentiator, and in large, prolonged dosages possibly as an immunosuppressora, future “diagnostic‐therapeutic” trials could examine this dichotomy to determine whether aphthous stomatitis and Behçet's syndrome are infectious or hypersensitivity d

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1978.tb01604.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

AbstractA double‐blind trial of a tetracycline suspension was carried out in 25 patients with recurrent aphthous oral ulcerations. A combined topical‐systemic treatment procedure was used. Both the placebo and tetracycline groups experienced reductions in ulcer incidence during the treatment period, whereas only the tetracycline group showed significant reductions in ulcer duration, size, and pain. Tetracycline treatment apparently alters the severity of the ulcer, but does not appear to affect those factors responsible for recurrences. The side effects recorded in patients taking tetracycline were comparable to those in patients on plac

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1978.tb01605.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

AbstractThe anthelmintic drug, levamisole, was shown to amplify the response of human peripheral blood lymphocytes to vegetable mitogens. A similar enhancement of blast formation in the mixed lymphocyte culture was also demonstrated. High concentrations of the drug led to depression of both of these responses. These observations led to studies in a rat breast cancer model in which immunopotentiation was demonstratedin vivo, and this effect was associated with tumor regression. As in the humanin vitrostudies, high doses of the drug were not associated with augmentation of the immune response and in this circumstance no inhibition of tumor growth was observed. Assuming that potentiation of immune responsiveness is of benefit to patients suffering from Behçet's syndrome, the development of clinical trials employing levamisole appears justified, as long as the drug dosage is carefully monitored

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1978.tb01606.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

AbstractTwenty patients with severe recurrent aphthous stomatitis were treated with a new drug, levamisole, to determine its effects upon the incidence and prevalence of recurrent aphthous stomatitis. The trial, conducted in a non‐crossover, double‐blind fashion, did not demonstrate any statistically significant differences when levamisole and placebo groups were compared over time either in the number of ulcers, number of ulcer‐days, mean duration of ulcers, or mean number of ulcers per day. Positive subjective results were experienced by the 10 patients receiving levamisole but these were not of sufficient magnitude to affect group mean differ

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1978.tb01607.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

AbstractForty‐eight patients with diagnosed recurrent aphthous stomatitis participated in a randomized double‐blind study of levamisole therapy. Each patient's response to treatment was determined by the following criteria: (1) days between attacks, (2) duration of lesions, (3) patient's self‐evaluation of pain, (4) investigator's clinical evaluation of patient's subjective treatment response. Statistical analysis of the levamisole and placebo groups for criteria 1 and 2 above revealed no significant difference. In contrast to the above findings, analysis of the investigator's recordings of patient's subjective treatment response showed that 26 % of the levamisole patients experienced marked or moderate improvement. None of the placebo patients were recorded as having experienced the same degree of benefit. Fourteen of 15 patients who complained of side effects were taking levamisole. The most common side effects were dysgeusia and hyper

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1978.tb01608.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY

摘要:

AbstractSixty‐five patients with recurrent aphthous stomatitis participated in a double‐blind study to evaluate levamisole. Nineteen of 34 patients improved on levamisole and only five of 31 patients improved on placebo (P>0.004, chi‐square with two degrees of freedom). After breaking the code and switching placebo patients to levamisole and non‐responders to an alternate dosage schedule, 46 of 60 patients noted clinical improvement.This is publication number 33 of the Dermatological Research Laboratories of Duke University Medical

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1978.tb01609.x

出版商:Blackwell Publishing Ltd    

年代:1978

数据来源: WILEY