ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1976.tb01765.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Abstract.Adult male rats of Simonsen strain were given a dose of 5000 r at 50 peak KV of x‐irradiation directed at the lower lip, which was everted through a hole in a lead rubber cylinder shielding the head and body of the animal. Light and electron microscopic observations were made on specimens of lip oral mucosa from animals killed at 2, 6, 26 and 50 h and at 12 days after irradiation. The experimental model met the aim of permitting the study of the sequential effects of a high dose of irradiation without causing ulceration of the mucosa.Widespread degenerative changes were noted in the basal cells as early as 2 h after x‐irradiation, increasing in degree up to 50 h. They included inflation of the outer nuclear envelope and rough endoplasmic reticulum (RER) with loss of ribosomes, swelling of mitochondria and disarrangement of cristae evident at 2 h, followed at 6 h by swelling of nucleus and cytoplasm and 26 h by frank membrane breaks. Irreversible degrees of damage were noted in a small though growing minority of cells. Immediate mobilization of the Golgi‐lysosomal system was evident as an increase in size of the zone, maximal at 2 h, and subsequent autophagic activity. Signs of recovery, beginning at 26 h, were noted in nuclear envelope, RER, intercellular space, and in mitotic activity by 50 h. Virtually complete recovery was seen at 12 days.It is held that the successful confinement of irradiation to a small tissue volume, the effective activity of the lysosomal system and the short epithelial turnover time were important factors in limiting the damage and in permitting rec

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1976.tb01766.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Abstract.In order to examine its prophylaetic eflect, Aetihaemyl® (Solcoseryl®) was administered to pregnant Swiss mice at various intervals before and after i. p. treatment with 30 mg/kg b. w. Endovan®: the optimal time for administration of the latter was found to be the 11.5.th day of pregnancy. A significant reduction (P≤0.01) of the rate of experimentally induced cleft malformations, as well as other types of abnormalities of the head area, was demonstrated in comparison to the control groups. These results were even more pronounced when the mother animals were treated in the following manner: 1/10 LD50(19.7 ml kg b. w.) of Actihaemy® 1 day. 10 and 5 min before Endoxan, followed by similar closes 5, 10 min and 2 days afterwards. Three prophylactic groups, from a total of 20, demonstrated a significant (P≤0.01) reduction in the cleft palate rate. Three additional groups showed reductions of more than 60(illegible) of enophthalmuses and over 25 (illegible) of encepha

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1976.tb01767.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Abstract.Rat's tongues were injured by cold and the reactive processes were observed by light and electron microscopy. Injured animals and untreated controls were injected with aurothiomalate and the cells in tongue muscles which contained gold were observed after increasing injection‐sacrifice time intervals.In the very rapid regeneration, gold‐containing macrophage‐like cells fused with each other and with well preserved parts of myofibers. The selectivity of gold localization suggested, at least morphologically, a macrophage to myoblast development. The possible factors affecting the rate of muscle regeneration have been discussed with special reference to the nature of the injurious stimulus and the type of cellular res

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1976.tb01768.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Abstract.The relation of the clinical picture of snuff dipper's lesions to the histopathological appearance was studied in 114 male dippers aged 20–88 years.Histological study revealed increased epithelial thickness, a vacuolated surface layer with wavelike, eosinophilic spikes directed toward the surface having a narrow, eosinophilic band as a demarcation toward the prickle cell layer, acanthosis, and a slight inflammatory reaction. Thirteen cases showed an increased number of eosinophilic granulocytes, and nine cases contained amorphous, weakly eosinophilic areas in the connective tissue papillae. No epithelial dysplasia was observed.Increased epithelial thickness, especially the presence of a vacuolated surface layer, was the only histologic feature that could be correlated with the severity of clinical appearance of the lesions. Deeply located changes, like inflammation and amorphous areas, however, were not reflected in the clinical grading of the lesion

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1976.tb01769.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Abstract.Explants of cheek pouch mucosa from 12‐ to 48‐hour‐old hamsters have been maintained in organ culture for up to 49 days with excellent preservation of tissue integrity and relationships. The technique uses gelatin sponge matrix in Leighton tubes with Eagle's Minimum Essential Medium (M.E.M.) supplemented with 10% calf serum and antibi

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1976.tb01770.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1976.tb01771.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Book review in this article:Differential Diagnosis of Oral Lesions, N. K. Wood&P. W. Goaz.

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1976.tb01772.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1976.tb01773.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY