摘要:

Polymorphonuclear neutrophils (PMN's) constitute the primary host resistance factor against infection. They are prominent cells in both the gingival tissue and gingival sulcus in most forms of periodontal disease. Although defective PMN function has been implicated in the pathogenesis of localized juvenile periodontitis (UP) and rapidly progressive periodontitis (RPP), this may not necessarily be the case in adult periodontitis (AP). A number of studies have failed to detect PMN dysfunction in AP. However, it may be that in this form of chronic inflammatory periodontal disease (CIPD) the defects in peripheral blood PMN function are subtle and the methods used may lack the necessary sensitivity. Chemiluminescence (CL) is the light energy produced by the PMN during its interaction with bacteria or other particles and has been demonstrated to correlate well with antibacterial integrity. Measurement of CL produced by phagocytically challenged PMN's may provide a very sensitive assay of the functional ability of these cells, and, hence, may be useful in assessing PMN activity in CIPD. Recent studies using PMN's obtained from periodontal diseased patients challenged with the periodontopathic organismFusobacterium nucleaiumhave revealed an elevated CL response compared to non‐diseased controls. These results are reviewed and areas for future research discusse

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1986.tb00592.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

Kimura's disease, eosinophilic granuloma of soft tissues, is a chronic inflammatory condition and appears as subcutaneous tumor‐like nodules in the head and neck regions. Histopathologically, it is characterized by the presence of lymphoid follicles, marked infiltration of eosinophils, fibrosis and vascular proliferation. This disease occurring in the orofacial region is relatively rare, only 14 cases having been previously reported. We describe 3 additional cases of Kimura's disease and discuss these in relation to angiolymphoid hyperplasia with eosinophili

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1986.tb00593.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

Preliminary studies (Lineweaver‐Burk, Ca2+calmodulin sensitivity) suggest that oral mucosa contains at least two cyclic AMP phosphodiesterases, one a high affinity (low Km) enzyme and the other a low affinity (high Km) enzyme. Analysis of the distribution of both enzymatic forms during oral mucosal regeneration revealed that the low Km, and high Km cAMP phosphodiesterase activities were significantly elevated prior to the first wave of cAMP accumulation and during the second cAMP wave. Although the cAMP peaks declined between 20–24 h, both cAMP phosphodiesterases remained significantly elevated at the wound site. The apparent Km of the low Km form increased from 5.3 to 7.5 uM, while that of the high Km form remained essentially unaltered 20 h after wounding. The low Km, and high Km cAMP phosphodiesterase activities in normal rat oral mucosa were not affected by epinephrine or insulin; were slightly inhibited by glucagon, and significantly inhibited by methylprednisolone. Imidazole and histamine activated both forms and theophylline was inhibitory to the enzyme. The high Km cAMP phosphodiesterase was sensitive, and the low Km form insensitive to Ca2+calmodulin stimulat

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1986.tb00594.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

Using anin vitrosystem, the growth characteristics and enzyme histochemical properties of 3 odontogenic keratocysts and 3 dentigerous cysts were studied. It was found that the epithelial cells of the keratocysts hut not of the dentigerous cysts grewin vitro.Furthermore, the epithelial‐like cells of the keratocysts showed the same activities of acid phosphatase and NADH‐diaphorase in vitro as earlier describedin vivo.These enzymatic activities were increased in epithelial‐like cells close to proliferating fibroblast‐like cells, indicating a close relationship between these two cell types. The results are discussed in the light of the known clinical behaviour of the keratocysts and certain conclusions are also drawn concerning the suggested neo plastic potential of the kera

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1986.tb00595.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

AbstractSeven oral squamous cell carcinomas developed in HMT rats were studied with light and electron microscopy. Two carcinomas in extra‐oral sites were also described. Histodifferentiation of oral squamous cell carcinomas ranged from well‐differentiated to poorly‐differentiated, comparable to that of the same disease in humans. Ultrastructural features characteristic of human oral carcinomas were observed in the HMT rat carci

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1986.tb00596.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

Chromosomal breakage and sister‐chromatid exchanges (SCE) were studied in peripheral lymphocytes of 9 patients with primary herpetic stomatitis (PHS), 12 patients with secondary herepetic stomatitis (SHS) and 12 controls. The incidence of chromosomal breakage was breakage was significantly higher in PHS patients (mean 23%, P.=0.0002) and in SHS patients (mean 20.25%, P. = 0.0003) compared to the controls (mean 4.2%). The incidence of SCE per 46 chromosomes was significantly higher in SHS patients (mean 16.564) compared with (P.<0.001) the controls (mean 11.367) and compared with (P.=0.00) the PHS patients (mean 12.13). It is concluded that both PHS and SHS patients exhibit structural chromosomal damage; SHS patients in addition exhibit more repaired chromosomal lesion

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1986.tb00597.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

The effect of a single injection of sodium fluoride (60 mg/kg) on the development of rat molar enamel beneath fluoride‐induced sub ameloblastic cysts was studied by transmission electron microscopy using un decalcified sections. Three bands of altered enamel were identified and defined as the cyst surface band, the hypo plastic band, and the hyper calcified band. The irregular cyst surface band, not previously described, was found to have two components: electron‐dense enamel globules and organic spherules. The electron‐dense globules consisted of small, randomly arranged crystals (confirmed by selected area electron diffraction) occurring within a stippled organic matrix. The organic spherules have staining properties similar to stippled material and lack a crystalline component. They may be a form of organic material being extruded from the underlying developing enamel. The critical role of normal matrix production and ameloblast Tomes’ process Structure on the development of the crystal orientation and rod pattern is di

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1986.tb00598.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

In a retrospective histological and clinical study, a multifactorial grading system was used for histological classification and grading of malignancy in 51 cases of squamous cell carcinoma of the tongue and floor of mouth The results indicated that the use of such a multifactorial grading system, consisting of 7 morphological paramaeters, including an evaluation of both the tumor cell population itself and the tumor host relationship, can serve as an important supplement to clinical judgement in determining the outcome of the oral tumor.

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1986.tb00599.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

Five lesions were studied to elucidate the histogenesis of cartilage in peripheral fibromas. Cytological features suggested direct transformation from fibroblast‐like cells to chondrocyles (cartilaginous metaplasia). Supportive evidence for such differentiation was the presence of neutral and acid mucopolysaccharides in the loose stroma of the lesions as well as in the ground substance of the cartilaginous centers. In one instance, the metaplastic cartilage showed bone formation. An increased number of oxytalan fibers could be demonstrated in the fibroma and in the cartilag

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1986.tb00600.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

Histopathological studies were made on the submandibular glands, obtained from 207 autopsy cases of patients, ranging in age from 40–98 years who had not had collagen diseases. Focal lymphocytic infiltration of the submandibular glands was more frequently seen in the cases of patients over 70 years (80.3%) than in those of under 70 years (53.8%). Generally, the incidence of foeal lymphocytic infiltration showed a trend to gradual increase with age. Immunohistochemically, a predominance of T cells (60–80%) was found in submandibular lesions with the majority (60–70%) belonging to the Leu 3a (subset (Helper/Inducer) and with less than 20% belonging to the Leu 2a+subset (Cytotoxic/Suppressor). The percentage of Leu 2aH subset was found to increase in the lesion of the periacinar area, and the acinar parenchyma appeared gradually to be damaged by the infiltrating lymphocytes. The findings in the present study suggest that focal lymphocylic infiltration in submandibular glands is a focal sign of immunological disorder, based on the autoimmunity associated with

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1986.tb00601.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY