摘要:

Abstract.Pulpal response of four calcium hydroxide liners, MPC 10®, MPC 12®, Dycal® and Pulpdent® were tested on primary and permanent teeth with zinc oxide and eugenol (ZOE) and silicate as controls. Responses of the pulps were evaluated in Rhesus monkeys, utilizing Class V cavity preparations at 3 days, 5 and 8 weeks. An equivalent number of anterior and posterior teeth were studied for all compounds. The Ca(OH)2liners, zinc oxide and eugenol (ZOE) and silicate controls were placed in 80 primary and 80 permanent teeth. Following perfusions the teeth were prepared utilizing routine histological procedures. The 3 day response of the calcium hydroxides was moderate with some disruption in the odontoblasts, vacuolization and mild inflammation underlying the cavity except Pulpdent which was more severe. At 5 weeks a decrease in inflammatory response and the formation of reparative dentin was similar for all calcium hydroxides tested at this time period. At 8 weeks more reparative dentin was noted with slight to moderate pulpal responses. At all time periods ZOE produced the least pulpal response while silicate produced the most severe response at 5 and 8 weeks.This study reports the biological responses of four calcium hydroxide compounds used as cavity liners in non‐exposures in a series of primary and permanent teeth of monkeys using ZOE and silicate as controls. Responses to the four Ca(OH)2compounds were moderate for all the experimental compounds except Pulpdent which was more severe at the early time period tested. ZOE produced a milder and silicate a severe response at all periods. All of these compounds were placed by random selection in anterior and posterior teeth of both arches and five teeth were evaluated in both primary and permanent teeth at 3 days, 5 and 8

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1976.tb01759.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Abstract.The osteopetrotic (ia) rat was examined as an experimental model for studying the dependence of tooth eruption on bone resorption. Iniarats eruption of incisors and first molars was rare and eruption of second and third molars was reduced and delayed. Autoradiographic studies of3H‐proline incorporation showed that delayed eruption was not due to reduced tooth formation. Microscopic study revealed distortion and failure of posterior growth of the apical ends of incisors, unresorbed bone blocking the eruption pathway for molars, and ankylosis of incisors and first molars to alveolar bone. A reduction in bone resorption, known to be the primary cause of the disease iniarats, is presumed to be the cause of the delayed or unerupted dentition. The effectiveness of attempts to increase bone resorption iniarats at an early age by injection of vitamin A and/or parathyroid extract or by parabiotic union with a normal littermate was determined by measuring their effect on the relative size of the tibial marrow cavity. Only parabiosis had a beneficial effect on bone resorption but surgical union could not be performed in animals young enough to affect eruption of incisors and first molars iniaparabionts. These results suggest that parabiotic union of neonatal rats should allow resorption to begin early enough to test the presumed dependence of tooth eruption on bone resorptio

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1976.tb01760.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Abstract.The supernatant portion of cultured human monocytes produces a biological factor known as colony stimulating factor. The addition of culture fluid containing colony stimulating factor to cultured human monocytes produced morphologic changes in the granular endoplasmic reticulum. Granular endoplasmic reticulum changed its appearance from long slender cisternae to a concentric pattern (whorls) averaging seven rows per structure 120 min following the addition of culture fluids containing colony stimulating factor.

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1976.tb01761.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Abstract.Stimulation of cell mediated immunity has been reported to be effective in bringing about clinical regression of carcinomas. The purpose of this pilot study was to investigate the possibility of introducing cell mediated immunity into an experimental animal‐chemical carcinogenesis system (dimethylbenzanthracene‐hamster cheek pouch) to serve as a model for the study of immunotherapy of oral cancer in humans. Contact hypersensitivity to dinitrochlorobenzene (DNCB) was induced in 17 Syrian hamsters via the abdominal skin. After secondary application of the allergen to the cheek pouch, local gross and histologic characteristics indicative of delayed hypersensitivity were observed. Control animals that had received only a primary or a secondary challenge with DNCB essentially showed no change. This study demonstrates that the buccal pouch of the Syrian hamster is capable of manifesting contact hypersensitivity to D

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1976.tb01762.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1976.tb01763.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY

摘要:

Book review of this article“Colour Atlas of Oral Histopathology” E. A. Marsland and R. M. Bro

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1976.tb01764.x

出版商:Blackwell Publishing Ltd    

年代:1976

数据来源: WILEY