摘要:

Much of the connective tissue degradation that takes place in periodontal diseases is mediated by proteolytic enzymes. Previous studies have focused on the action of proteinases released by invading polymorphonuclear neutrophils and macrophages, and bacterial enzymes. In view of recent work establishing that resident connective tissue cells can be induced by cytokines to bring about the destruction of their own matrix, we propose a new hypothesis. In this we envisage that a critical step is the interaction of bacterial antigens with inflammatory cells, resulting in the production of a cytokine, interleukin‐1. Our interpretation ofin vitroevidence is that the loss of connective tissue attachment and bone matrix resorption in periodontal diseases is mediated by metalloproteinases such as collagenase and stromelysin released by cells of the periodontium. Such proteolytic destruction can be induced by interleukin‐1, whose production may not be dependent on a specific microbial flora but may be triggered by a number of organisms. It is now clear that interleukin‐1 has multiple actions on both immune and non‐immune cells; these include the induction of lymphocyte differentiation and proliferation and the stimulation of bone and cartilage resorption, and prostaglandin and metalloproteinase synthesis by connective tissues. It seems likely that further knowledge about the production and function of this cytokine will have an increasing impact in many diseases that involve resorption, particularly since interleukin‐1‐like molecules can be produced by cell types other than monocytes/macrophages, including keratinocytes and

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1986.tb00616.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

Growth characteristics and acid production of oral isolates ofCandida albicansandCandida glabratain glucose supplemented and glucose‐free, pooled, human whole saliva were examined. BothCandidaspecies exhibited sigmoidal growth curves in hatch cultures of mixed saliva, supplemented with glucose. The growth ofCandidain saliva was accompanied by a rapid decline in pH from 7.5 to 3.2 over 48 h and the major acidic components initiating and sustaining this pH drop were pyruvates and acetates. These acidic metabolites may play an important role in the pathogenesis of oralCandidainfection

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1986.tb00617.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

A 42‐year‐old female presented with a 2.5 cm symptomless swelling on the left lateral surface of the tongue. Histologically, there were large, often pleomorphic, fibroblast‐like and histiocyte‐like cells, multinucleate giant cells and cells of variable morphology. Many of the cells had abundant vesicular cytoplasm. There were also aggregations of neutrophilic or eosinophilic leukocytes, or both. The cells in some areas formed a fascicular or storiform pattern, or both. Ultrastructurally, the vesicular appearance was due mostly to markedly dilated endoplasmic reticulum, but many of the neoplastic cells contained some lipid. There were some myofibroblasts and a few xanthofibroblasts. The cells of variable morphology had many of the ultrastructural features of the fibroblast and histiocyte‐like cells. There were also some small undifferentiated cells with minimal cytoplasm. These ultrastructural features confirmed the histological diagnosis of malignant fibrous his

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1986.tb00618.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

Four cases of focal epithelial hyperplasia (FEH) were studied immunohistochemically, using monoclonal antibodies against the M1 subunit of ribonucleotide reductase and different cytokeratin polypeptides. The FEH lesions showed, compared to normal oral mucosa, extensive alterations in their staining patterns. This included ectopic suprabasal M1 staining and the novel expression of cytokeratin polypeptides differing from those previously reported for other HPV infections. The results arc discussed in relation to the causative agent, human papillomuvirus, and its expression in focal epithelial hyperplasia.

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1986.tb00619.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

In order to further investigate the known influence of iron deficiency on 4NQO oral carcinogenesis in the rat, groups of iron‐deficient and iron‐sufficient Charles River white rats were painted with carcinogen for 8 weeks or 14 weeks and then left untreated for 32 weeks or 26 weeks respectively. Tumour development and epithelial dysplasia were assessed at the time of killing. Animals painted for 14 weeks showed more severe dysplasia than those painted for 8 weeks, but no significant differences were noted between corresponding iron‐deficient and iron‐sufficient

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1986.tb00620.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

In a retrospecitve study of 112 cases, an attempt has been made to further delineate the histopathological parameters which are useful in making a diagnosis of oral lichen planus. The results of this study show that mononuclear infiltration beneath and adjacent to the epithelium, parakeratosis and degeneration of the basal layer of the epithelium were consistent features. Linear regression analyses of the parameters studied provided partial support for a cell‐mediated immune mechanis

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1986.tb00621.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

Biopsies from lichen planus affected oral mucosa were compared with biopsies from healthy oral mucosa, in terms of the number of mast cells, their location and their morphological alteration at the light microscopic and electron microscopic level. In comparison with the normal oral mucosa an increased number of mast cells was found below the subepithelial infiltrate. This difference was statistically highly significant (p<0.001). In the deeper part of the infiltrate mast cells were found to contain granules which presented an altered morphology upon electron microscopic examination. These cells had many of the ultrastructural changes that have been reported for mast cells undergoing degranulation. The present morphological observations suggest that mast cells participate in the recruitment of lymphocytes to the subepithelial infiltrate.

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1986.tb00622.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

There is evidence for synergy between tobacco and alcohol in the etiology of oral cancer but the reason for such an effect is unclear. One possible explanation is that alcohol enhances the penetration of carcinogens through the oral lining. We measured the permeabilityin vitroof three regions of porcine oral mucosa to the tobacco associated carcinogen, nitrosonornicotine (NNN) alone and in the presence of 5% or 50% ethanol. 50% ethanol did not significantly alter the permeability of oral mucosa to NNN except for buccal mucosa, where it was reduced. However, there was a significant increase in the permeability of gingiva and floor of mouth mucosa (but not buccal mucosa) in the presence of 5% ethanol; this increase occurred after far shorter exposures for floor of mouth than for gingiva. These results accord well with studies showing (a) that the Door of mouth is a “high risk area” for oral carcinoma and (b) that there is an increased relative risk of oral cancer for heavy smokers and drinkers and, in particular, for those individuals who consume beverages with a low alcohol cont

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1986.tb00623.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

Oral epithelial atypia and foci of acantholytic dyskeratosis (FAD) were investigated in 54 rats treated with the carcinogen 0.5% (w/v) 4‐nitroquinoline‐N‐oxide in propylene glycol and in 18 rats treated with propylene glycol only. The palate of each animal was painted 3 times weekly for up to 9 months and rats were killed at monthly intervals. A gradual significant increase in the epithelial atypia indices of the palatal and lingual tissues (anterior and posterior of the intermolar tubercle) was observed with a maximum value of 17–22 of a possible 75 at 28–32 weeks. No significant differences were noted between the atypia indices of the palatal and lingual tissues. FAD were not evident in the palate or lingual tissues before 12 weeks and 16–24 weeks, respectively, and although the palate consistently showed more FAD compared with the lingual tissues the differences were not significant. Features of epithelial atypia and FAD were absent in the 18 control rats treated with propylene glycol only and in 8 untreated control animals. At 28 weeks of 4NQO treatment 2 of 5 rats, at 32 weeks 3 of 4 rats and at 36 weeks 3 of 3 rats had developed infiltrating squamous cell carcinomas in either/both the palate or tongue. The results suggest that epithelial dysplasia and acantholytic dyskeratosis may be late morphological features of a more fundamental change occurring earlier in the process of tumour

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1986.tb00624.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY

摘要:

AbstractA recurrent infiltrative ameloblastoma of the mandible with a predominantly “follicular pattern” of the epithelial component is studied. The stroma contains abundant myofibroblasts; these cells have been described in benign and malignant infiltrative processes. This raises the question of the relationship between the presence of myofibroblasts and the aggressive behavior of a neopl

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1986.tb00625.x

出版商:Blackwell Publishing Ltd    

年代:1986

数据来源: WILEY