ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1985.tb00474.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

Leukocyte inhibitory factor (LIF) production in response to streptococcal antigens and oral mucosa was examined as a possible pathogenic mechanism in recurrent aphthous ulceration (RAU). Mononuclear cells from RAU patients and controls were stimulated with antigens prepared from two species of streptococci and from oral mucosa.Candida albicansand foreskin were tested as control antigens. There‐were some statistically significant differences in leukocyte migration inhibition between patients and controls with some concentrations ofStreptococcus sanguis(ATCC 10556) andC. albicans, and a trend toward low migration indices with oral mucosa. However, the roughly equal numbers of patients and controls responding positively to each antigen and the large background variation suggest a lack of biological significance. LIF production did not increase consistently in the early stages and did not correlate with ulcer development in patients studied sequentially. We conclude that LIF production (at least in response to the antigens tested) plays no pathogenic role in RAU. Our data do not support the hypothesis that a specific cell‐mediated sensitivity to streptococcal antigens is involved in

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1985.tb00475.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

An immunohistochemical technique was used on paraffin‐embedded tissues of four cases of calcifying epithelial odontogenic tumors (CEOT). These studies were performed to gain an additional understanding of the nature of amyloid‐like deposits in these tumors. For these studies antibodies to Type IV collagen, laminin. and the five classes of intermediate filament proteins were employed. In all of the tumors examined basement membrane components and intermediate filament proteins (cytokeratin) were demonstrated both in the epithelial tumor islands and within the extracellular amyloid‐like deposits. Antibodies to vimentin intermediate filaments were localized only in the stromal fibroblasts. Limited proteolysis or the use of a chaotropic agent was required to express the antigenic determinants present. These studies substantiate the presence of basement membrane components in the amyloid‐like deposits of CEOT. In addition, these extracellular deposits are shown to be heterogenous in composition by the immunohistochemical demonstration of cytokeratin intermediate filament p

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1985.tb00476.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

The distribution of fibronectin in human oral mucosal vesiculo‐bullous diseases was studied by indirect immunofluorescence. Subepithelial (benign mucous membranepemphigoidanderythema multiforme) as well as intraepithelial (pemphigus vulgarisanddyskeratosis follicularis) lesions were selected. A marked accumulation of fibronectin was generally found in the lamina propria and basement membrane region, except indyskeratosis follicularis.Intraepithelial staining occurred inerythema multiformeanddyskeratosis follicularis.Inpemphigus vulgarisintercellular staining was seen in relation to acantholysis. Both mucous membranepemphigoidanderythema multiformeshowed a linear accumulation corresponding to the intact basement membrane. However, onlypemphigoidlesions disclosed fibronectin on the epithelial side of the vesicle

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1985.tb00477.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

In this study, the gingival condition of patients with neutrophil dysfunction has been evaluated. The data demonstrate increased gingival disease as well as oral ulcerations in patients with neutrophil dysfunction syndromes and are consistent with a critical role of neutrophils in oral health.

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1985.tb00478.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

Four adult Rhesus monkeys provided 120 teeth for buccal Class V cavities. Twenty‐nine were non‐exposed controls and 91 were exposed for 3 intervals. All 120 teeth were capped with a hard set Ca(OH)2, medicament, restored with amalgam, 57 evaluated after 1 year and 63 after 2 years. Of the 91 exposed pulps, 45 showed complete healing, 25 showed pulpal inflammation varying from acute to chronic, 12 showed severe pulpal breakdown and abscess formation and 9 were necrotic. No difference was observed in the healing response between the 3 exposure times. New hard tissue formed at, or subjacent to, the medicament in 77 of 91 exposed pulps with a tunnel defect frequently present, running from the medicament interlace to the pulp. This study demonstrates that recurring pulp inflammation observed after 1&2 year direct pulp capping, is associated with bacterial contaminat

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1985.tb00479.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

The use of smokeless tobacco (ST) products, such as snuff and chewing tobacco, was investigated in a school population of 565 males with a mean age of 13.8 years. All students completed a tobacco usage questionnaire and were given intraoral examinations by a team of dentists to determine the possible relationship of ST usage to the presence of gingivitis, gingival recession, mucosal pathology and caries. The overall prevalence of ST usage was 13.3%, which was much higher than the 1.4% prevalence of cigarette smoking. Pairwise chi square analysis revealed that there was no relationship between ST usage and the prevalence of gingivitis, but that the prevalence of gingival recession was significantly elevated in ST users, P<0.001. The odds of having gingival recession were 9 times greater in the students using smokeless tobacco as compared to healthy, non‐user cohorts. ST usage did not affect the prevalence of gingival recession in students without gingivitis. The frequency of occurrence of soft tissue pathology was significantly elevated, about 6‐fold in students who used smokeless tobacco, as compared to non‐users. P<0.01. This was principally due to the increased prevalence of while mucosal lesions in smokeless tobacco users. However, there was no attributable risk for mucosal pathology in ST users who were free of gingivitis. Similarly, the use of smokeless tobacco was associated with a 1.6‐fold elevation in mean DMF in students with gingivitis, P<0.001, but this increase in caries experience was not seen in ST users who were free of gingivitis. In summary, in students with clean mouths that were free of gingivitis, the use of smokeless tobacco was not associated with a change in the prevalence of gingival recession, mucosal pathology, or in the mean DMF score. In contrast, smokeless tobacco usage was a significant risk factor in individuals with co‐existing gingivitis, associated with a marked increase in the prevalence of gingival recession, mucosal pathology and caries e

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1985.tb00480.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

Multinodular hyperplastic foci of oncocytes found in mouse submandibular glands were examined ultrastructurally, and their morphogenesis discussed. The oncocytic foci showed lobular architecture surrounded by myoepithelial cells, and tubular formations were frequently present. The cytoplasm of the oncocytes was distended by tightly‐packed and non‐oriented mitochondria which varied in size and shape. Furthermore, varying numbers of electron‐dense fine granules, which were remnants of secretory granules of granular duct cells, were scattered in the cytoplasm. Within the salivary gland parenchyma neighboring the hyperplastic foci of oncocytes, intermediate‐type cells between oncocytes and normal salivary gland epithelia were found. The result of the present study shows that the oncocytic change has a tendency to be more frequent in the granular ducts and less in the striated ducts, and that some oncocyte‐transformed cells proliferate to form nodular hyperpla

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1985.tb00481.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

Techniques in Immunocytochemistry, Vol 2.Eds. Bullock GR, Petrusz P.

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1985.tb00482.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY