摘要:

Available data in United Stales on morbidity, mortality and survival is reviewed and trends discussed. Oral squamous cell carcinoma is a small problem in numerical terms, but is a highly lethal disease. The diagnosis is not difficult for the competent pathologist but problems arise in the diagnosis and prognosis of potentially malignant conditions. Our understanding of the behavior of dysplastic lesions is limited and any attempts to determine individuals “at risk” should be encoura

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1984.tb01432.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

Ultrastructural examination of 6 mucoepidermoid carcinomas (4 from parotid salivary gland and 2 from lung) was used to investigate tumor cell types, their interrelationship, histogenetic aspects and factors involved in the multiplicity of histological patterns in this tumor. On the basis of light‐microscopic cellular features, mucoepidermoid carcinomas are generally thought to be formed by 3 principal cell types, mucinous, squamous and intermediate. However, low‐magnification electron micrographs reveal that there arc 2 basic tumor‐cell types interpreted as modified luminal epithelial and myoepithelial cells. Both cell types may independently show a range of line structural modification and organizational arrangement, Luminal epithelial cells have varying degrees of mucin production and lumen, formation in some regions, while modification of these cells is one mechanism for squamoid and frankly squamous appearances in other areas. Preferential proliferation of the second type of tumor cell aligned on the outer aspect of luminal epithelial cells is responsible for the development of isomorphic regions composed of intermediate cells. Squamous metaplasia can also occur in relationship to these latter cells. Based on these observations and recent ultrastructural and histochemical studies of salivary gland tumors, it is suggested that, in addition to the excretory duct, neoplastically altered cells in the acinar‐intercalated duct region must be considered as a potential source for the development of mucoepidermoid car

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1984.tb01433.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

To examine the pattern of proliferation of mast cells in the skin of Swiss Webster mice, single or multiple pulses of ‐3H‐thymidine. autoradiography and selective staining techniques were combined to detect DNA synthesis. A very low labelling index was found for the mast cells of normal skin but alteration of the mast‐cell population using the chemical carcinogen dimethylbenzanthracene led to increased labelling of mast cells. A series of studies of experimentally altered skin showed a pattern of mast cell labelling which suggested derivation of new mast cells by local self‐replication. The labelling pattern indicated that mast cells labelled after 1 h divided to produce 2 daughter cells and that the rate of increase in the number of labelled mast cells following repeated labelling for up to 20 days was linear. These data do not suggest major recruitment of mast cells from a distant source during this

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1984.tb01434.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

Sand rats transferred from their natural environment to laboratory conditions develop diabetes, cataracts, vertebral lesions, liver tumors, malocclusion and gingival inflammation. In the present study 43 sand rats of different ages were randomly chosen from a colony maintained for 13 years in the laboratory. Macroscopical, microscopical and radiographical examinations of the dental apparatus showed marked abnormalities in animals older than 6 months. The incisors were affected more than molars with an asymmetry between the right and left side of the jaw. Pathological alterations in the incisors included variations in length and curvature, lateral inclination, coronal fractures and pulpal calcifications. The enamel on the buccal aspect of these teeth had a scalloped appearance with corresponding meta‐plastic changes and folding of the ameloblastic layer. Coronal fractures were also found in molar teeth and were accompanied by marked hypercementosis. These changes are consistent with those reported in rodents with induced hormonal imbalance and may be associated with the diabetic state of aging sand rats. These gerbils are suggested as a model for studying the role of age‐related disorders in the pathogenesis of certain dental abnormalit

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1984.tb01435.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

A mandibular spindle‐cell sarcoma originally diagnosed as malignant fibrous histiocytoma displayed a whorl‐like histological structure and cellular pleomorphism. By electron microscopy the tumor cells showed prominent basal laminae around the tumor cells and bundles of myofilaments with attachment plaques. In support of the ultrastructural observations, immunofluorescence (IF) microscopy with antibodies to laminin, the major component of basal lamina, gave a bright pericellular staining of the tumor cells. IF microscopy using antibodies against intermediate filament (IMF) proteins revealed the presence of desmin, the muscle‐type of IMF protein, in most tumor cells. On the other hand, staining for myoglobin was negative. The data are consistent with the diagnosis of leiomyosarcoma rather than malignant fibrous histiocytoma, and suggest that expression of desmin and laminin can be useful markers of smooth‐muscle derivation of Sarcomatous

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1984.tb01436.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

TPA, a tumor promoter whose initial site of action is the cell membrane, was examined for its actions on hamster oral mucosa using light and scanning electron‐microscopic procedures. Hamster check‐pouch explants were culturedin vitro, then treated for 72 h with 1.6 × 10−8M TPA. Treated cultures showed a higher mitotic index and more extensive growth than control cultures. Epithelial cells in the control cultures appeared polygonal, with thin, small to medium microvilli. The cells in the treated cultures showed variable shape and surface morphology. Some were interconnected by broad cytoplasmic extensions while others demonstrated long, thin processes that traversed great distances. The unusual surface morphology may be a manifestation of altered phospholipid metabolism that produces a more “fluid” cytoplasmi

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1984.tb01437.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

The oral carriage of yeasts and coliforms in a healthy adult population and a group of patients with malignancies, undergoing cytotoxic therapy was investigated. A quantitative increase in the intra‐oral carriage ofCandidaspecies and coliforms was observed during cytotoxic therapy. The most frequent yeast and the coliform isolated wereCandida albicansandEscherichia coli, respectively. Thus, the oral cavity may constitute a reservoir of potentially pathogenic flora in patients on cytotoxic therap

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1984.tb01438.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

Little is known about the role of lipid metabolism in oral mucosal epithelia, although lipids probably play significant roles in the barrier function and in the production of energy for the various epithelial biosynthetic activities. The metabolic fate of exogenously added14C‐labelled oleic acid in pure epithelial sheets from hamster cheek‐pouch has been investigated. Significant amounts of the label from the tatty acid were found in phosphatidyl choline, sphingomyelin and triglyceride fractions. Lesser amounts were found in cholesterol, cholesterol ester, ceramide and phosphatidyl ethanolamine. Estimations of the amount of ATP produced by both glycolysis and by fatty‐acid β‐oxidation indicated that the 2 activities were essentially equal, which is in contrast to that reported for the epidermis. The results suggest that the oral mucosal epithelium, like the epidermis, is an active lipid‐metaboliz

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1984.tb01439.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

This study was undertaken to determine whether or not the blood group H‐antigen reactivity of oral epithelium has value in predicting malignant transformation. Tissue from 3 groups of patients was studied retrospectively, using an immunoperoxidase technique. Two biopsy specimens from each patient, obtained at different times but from the same site, were examined for the presence of H‐antigen. Group 1 consisted of 16 patients in which the initial biopsy was histologically benign, but the subsequent biopsy revealed epidermoid carcinoma. The initial biopsies in Groups II (17 patients) and III (17 patients) revealed epithelial dysplasia. Whereas the subsequent biopsy in Group II revealed carcinoma, the subsequent biopsy in Group III remained non‐invasive. Normal epithelium from 64 patients was also studied.The results showed that in normal epithelium, H‐antigen‐negative cells are rarely seen, but 81% of the initial benign specimens of Group I showed antigen‐negative areas. Therefore, it was concluded that altered H‐antigen reactivity in histologically benign epithelium may serve to predict eventual malignant transformation, and that immunologic de‐differentiation precedes histologic dedifferentiation. A comparison between the initial biopsy specimens of Groups II and III yielded nearly identical results and showed that it was not possible, on the basis of the H‐antigen reactivity, to predict which dysplastic lesions would progress to epi

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1984.tb01440.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY

摘要:

To study the regulation of collagen degradation in periodontium, human gingival homogenate was incubated at 36°C and the release of hydroxyproline was assayed as a measure of collagenase activity. Phenylmethylsulfonyl fluoride, soybean trypsin inhibitor and scrum albumin inhibited thein vitrocollagenolysis while p‐aminophenylmcreuric acetate, a sulfhydryl reagent, increased the degradation. When latent collagenase obtained from gingival fibroblast culture was added to the incubation a marked increase in the collagen degradation was found. This increase was prevented by phenylmethylsulfonyl fluoride. The data suggests that collagenase may exist in gingiva partly in a latent form and its activation may be brought about by 2 mechanisms. A serine proteinase present in tissue may activate collagenase by producing a limited clevage, or the activation may occur through a reaction that involves the sulfhydryl groups of the collagenase molecu

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1984.tb01441.x

出版商:Blackwell Publishing Ltd    

年代:1984

数据来源: WILEY