摘要:

Abstract.The biosynthesis of collagen molecules and their subsequent assembly into fibers involves a complex series of post‐ribosomal modifications which occur intracellularly and extracellularly. Some of these subtle alterations lead to the formation of intramolecular and intermolecular cross‐links, whereas others seem to dictate the 3‐dimensional organization of the collagen fibers. For their normal function, tissues require an optimum amount of collagen and proteoglycans. Such a balance coupled with specificity built into collagen seems to assure adequate function. Changes in the rates of synthesis, turnover or transcription of genetic information which affect the type of collagen deposited at a particular site may lead lo a stale of disease.It is hoped that our current understanding of such mechanisms, coupled with our ability to inhibit or accelerate some of these processes, will allow us lo effectively control the metabolism of connective ti

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1973.tb01682.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

Abstract.Clinical observation of a family with consanguinity and vitamin D‐resistant rickets is presented. Patients were studied by means of clinical observation and electron optic analysis, specifically that of scanning electron microscopy. The genetics of the condition is discussed with special reference to the effect of consanguinity on the kindred. Differential diagnosis with other hypophosphatemic conditions and inborn errors of calcium metabolism are also note

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1973.tb01683.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

Abstract.A new composite restorative material, Enamelite, has recently been introduced for the conservative treatment of cervical erosion and hypoplastic enamel surfaces. The pulpal response elided by the restorative material was investigated in teeth of the vervet monkey and compared to a modified zinc oxide‐eugenol cement.Buccal or labial Class V cavities were prepared in 128 teeth in six vervet monkeys. The teeth in contralateral segments were restored with the restorative and control materials, respectively. The experimental animals were killed at 4, 14 and 42 days.The restorative and control materials exhibited about the same minimal degree of cellular displacement and inflammatory response at each of the three postoperative time intervals.The percentage of specimens with reparative dentin increased progressively with time. At all three intervals the restorative material elicited a greater response than the control zinc oxide‐eugenol cement.The results suggest that the clinical application of the restorative material on cervical eroded or hypoplastic enamel surfaces without a protective lining is a safe proced

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1973.tb01684.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

摘要:

Abstract.Collagen metabolism of the operculum overlying the crown of the mandibular third molar was studied in patients with and without pericoronitis. The tissues were classified as (J) overlying unerupted lower 3rd molars, (II) the operculum overlying partially erupted lower 3rd molars, (III) same as (II) except in patients having a positive past history of pericoronitis, and (IV) same as (II) except in patients exhibiting signs and symptoms of active infection. All classes of tissue were found to contain 81–82 % water. The total protein recovered in these tissues increased progressively from class I to class IV due to an effect on the acid‐soluble fraction. The total collagen levels, on the other hand, decreased. This decrease was similar for class II and III tissues, while the greatest loss of collagen was demonstrated in class IV tissues. All four classes of tissue contained essentially the same concentration of acid‐soluble collagen. The loss of collagen appeared to parallel an increased collagenolytic activity of these tissues in culture. Collagenolytic activity of class II and HI tissues was increased and class IV tissues exhibited the greatest increase. The overall changes in protein and collagen metabolism in these tissues due to partial tooth eruption and subsequent infection appeared similar to those observed by others in extra‐oral connective tissues subjected lo injury and inflammation. Changes in collagen metabolism could not be correlated with the reported increased susceptibility to pericoronitis of previously infected tissues. The only change observed in these tissues was a higher proportion of acid‐solubl

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1973.tb01685.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1973.tb01686.x

出版商:Blackwell Publishing Ltd    

年代:1973

数据来源: WILEY