摘要:

More than 65 distinct types of human papillomavirus (HPV) have been identified to date. Several of the HPV types have been proposed as etiologic agents of squamous cell carcinoma. In the oral cavity, HPVs have been found associated with several benign squamous cell proliferations. Evidence from histology and DNA hybridization studies suggests that HPV is also involved in oral carcinogenesis. It is apparent, however, that substantial amount of confusion exists in the diagnosis of oral HPV infections. The keratotic, papillary lesions in the oral cavity are usually small and easily overlooked. The gross appearance of these viral lesions is not distinct enough to be readily diagnosed by the clinicians. Degenerative changes found on oral mucosa frequently simulate koilocytosis. Thus, caution should be exercised to avoid overdiagnosis of HPV infection in the oral cavity. The present review summarizes the current evidence available on HPV infections in general and on oral HPV infections in particular. The diagnostic techniques available as well as the problems encountered in the distinction of these lesions are also discussed in short.

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1991.tb00936.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

Three case histories are presented in which solid intraosseous ameloblastomas developed at the site of histologically verified odontogenic cysts.

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1991.tb00937.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

The effect of calcitonin (CT) on alveolar wound healing was studied with histomorphometric methods. Wistar rats weighing 80–90 g were submitted to extraction of the three mandibular molars. Half of them were injected intraperitoneally with daily therapeutic doses of CT. The control group received no further treatment. All the rats were killed 14 days after the onset of the experiment. Bone healing was impaired in CT treated animals and involved a more intense bone remodeling activity. Bone resorptive areas were present both on the profiles of the newly formed bone and on the alveolar ridge surface. These results suggest that CT would accelerate the process of bone healin

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1991.tb00938.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

An epizootic or focal epithelial hyperplasia (FEH) or Morbus Heck in a pygmy chimpanzee (Pan paniscus) colony is described. Papovavirus‐like particles were observed in the nuclei of epithelial cells. Analysis of the DNA of the lesions revealed an episomal papillomavirus‐specific band with a molecular size of approximately 8,000 bp. In situ hybridization under high stringency conditions showed cross‐hybridization between the chimpanzee papillomavirus DNA and human papillomavirus (HPV) type 13. The latter virus is uniquely associated with oral disease in man. This is the first demonstration of the association of a HPV 13‐related pygmy chimpanzee papillomavirus (PCPV) and oral epithelial hyperplasia in a nonhuman

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1991.tb00939.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

HIV‐related oral candidiasis was investigated in 71 HIV‐seropositive patients who received interviews, oral examinations and hematologic investigation. Diagnosis of candidiasis was based on clinical signs and examination of PAS‐stained smears. The frequency of candidiasis was 24/71 (34%). The clinical presentations were pseudomembranous 8 (11%), erythematous 14 (20%), angular cheilitis 3 (4%). Twenty‐six patients (37%) had candidiasis or were receiving antifungal treatment for recurrent pseudomembranous type. Twelve of 13 (92%) patients with AIDS and 14/58 (24%) without AIDS were affected. Bivariate analyses showed significant associations with AIDS, the use of zidovudine, low T4‐count, xerostomia: marital status (sometime married), restricted performance status and age of>35 yr. Multivariate logistic regression analysis showed that the presence of xerostomia was an independent and statistically significant predictor of HIV‐related oral candidiasis. T4‐count and restricted performance status were the second and third most importa

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1991.tb00940.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

Different types of inflammatory cells in healthy major and minor salivary glands (SG), including those in labial and palatal non‐autoimmune sialadenitis, were quantified immunohistochemically. Plasma cells, mainly IgA type predominated in all SG types, with the smallest number seen in the palatal glands. The numbers of common leukocyte antigen (CLA) reactive lymphocytes were greater in major SGs than in minor ones and were predominantly UCHLl positive T cell type. Macrophages and neutrophils were absent in palatal glands, rarely present in labial ones and usually present in major SGs. Increases in the number of IgG and IgM plasma cells and lymphocytes (CLA+) which include both UCHL1+T and L26+B cell types, were found in non‐autoimmune labial and palatal sialadenitis. There was no significant correlation between the number of the inflammatory cells and the degree of glandular atrophy in both labial and palatal non‐autoimmune sialadenitis. Increase in their number represents a protective response of these glands in contrast to the inflammatory cells in major autoimmune sialadenitis playing there a pathogenetic

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1991.tb00941.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

Neurotoxicity is the dose‐limiting side effect of vincristine sulfate. This study was designed to investigate neurotoxicity affecting the head and neck in a population of cancer patients receiving vincristine. Forty patients were given baseline interviews and oral examinations, and these were repeated weekly for the first 7 wk of treatment. Twenty‐six patients (65%) developed symptoms of neurotoxicity: orofacial pain, 22/40 (55%); numbness 1/40 (2.5%); paresthesia 4/40 (10%); difficulty with mastication 1/40 (2.5%); involuntary movements 3/40 (7.5%); and voice changes, 4/40 (10%). Most symptoms occurred in the first week except voice changes (hoarseness and weakness) which did not occur until the third week of treatment. Using Fisher's exact test, neurotoxicity affecting the orofacial area was found to be significantly associated with younger age and single marital status indicating that psychosocial factors may affect susceptibility to the neuro‐toxic effects of vincristine. This prospective cohort study confirms previous anecdotal reports of vincristine neurotoxicity affecting the head and

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1991.tb00942.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

The knowledge of occupational hazards from blood‐borne viruses, and practices related to cross‐infection control were studied in Jordanian dental students. A survey in July 1990 showed that over 90% were aware of the existence of vaccines against hepatitis B virus and most appreciated the possible long‐term hepatic sequelae of hepatitis B virus infection. Nearly 50% had already been immunized against hepatitis B and a further 4% intended to be vaccinated. Autoclaves were used by more than 80% for the sterilization of dental instru

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1991.tb00943.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY

摘要:

The changes in a permanent central incisor of a patient suffering from hypophosphatasia, were investigated light microscopically and compared with those of two of his primary teeth. In addition his other central incisor was studied with transmission and scanning EM. The changes in permanent teeth were similar to those of the primary dentition, including loss of cementum and the presence of deep resorption areas in dentin. Afibrillar cementum was detected with EM, and was attached to dentin surface. The presence of a thick layer of bacterial plaque was a prominent feature in all the teeth examined. A large number of bacteria was also found in resorption bays. It is suggested that bacteria may play an important role in the destruction of soft and hard tissues leading to loss of teeth in hypophosphatasia.

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1991.tb00944.x

出版商:Blackwell Publishing Ltd    

年代:1991

数据来源: WILEY