摘要:

AbstractInterepithelial cells are found in all epithelia of the internal and external surfaces of the mammalian body. The regional differences of these Interepithelial cells and their function are not completely known so far. The quantitative and qualitative changes of the interepithelial cell population were investigated in germfree, specific pathogen‐free and conventionalized mice by light and electron microscopy. Germfree and specific pathogen‐free animals did not show significant differences in the number of interepithelial cells. In the epithelium of the tongue a mean of 7.4 cells per 1000 basal cells is found. After conventionalization a significant increase to 14.4 interepithelial cells per 1000 basal cells is observed. The number of cells in the buccal epithelium is constantly about 20% higher than in the epithelium of the tongue. In the oral mucosa lymphocytes, cerebriform cells and Langerhans cells are an integral component of the epithelium. In contrast to the monostratified intestinal mucosal epithelium, which is considered a secondary lymphatic tissue, the interepithelial lymphocytes of the oral mucosa are not significantly decreased in germfree animals. This could indicate that the oral mucosa functions partly as a primary lymphatic tissue. Interepithelial cerebriform cells and Langerhans cells increased after conventionalization with a maximum after 10 days in response to exogenous antigens. Both cells are immunologically important. The observations prove that the oral mucosa represents a local immunologic system in which the Langerhans cell plays an important part by formation a reticulo‐epithelial t

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1980.tb01389.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

AbstractCysts lined by epithelium were often found in association with tooth‐germ isografts in hamster cheek pouch. They developed from odontogenic epithelium and were in close relation to the crowns of involved teeth. Cysts associated with tooth‐germ isografts from 5‐day‐old animals (17 out of 36) commenced their formation shortly after transplantation as a result of enamel organ degeneration. Teeth associated with these cysts often showed enamel hypoplasia. Accordingly, 86 teeth involved in human dentigerous cysts were examined and 43 were found to possess areas of enamel hypoplasia on their occlusal surfaces or incisal edges. It is suggested that the pathological process initiating cystic degeneration in the enamel organ was also accompanied by degeneration of ameloblasts. When tooth‐germs from 2‐day‐old hamsters were transplanted, cystic spaces developed only after completion of enamel formation, 6 weeks following transplantation (in six out of 11 transplants), as a result of separation between the cells of the reduced enamel epithelium. Enamel hypoplasia was not a conspicuous feature. These experimental and clinical observations suggest that there may be at least two types of dentigerous cyst, perhaps with different causes, arising at different stages of toot

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1980.tb01390.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

AbstractThe concentration of parotid fluid electrolytes and glucose was measured in: (a) a subject during an acute exacerbation of chronic recurrent parotitis and then at various stages of recovery following treatment with corticosteroids: (b) a group of seven patients seen during an acute exacerbation and then when clinical symptoms had subsided; and (c) a group of 22 patients studied at various stages of parotitis. During acute exacerbations sodium and chloride concentrations were markedly elevated despite the very low flow rate and potassium was only half (he normal salivary level Phosphate concentration was also extremely low; glucose was very high. During recovery flow rate gradually increased while sodium, chloride and glucose levels fell. Potassium returned quickly t normal while the phosphate level rose very gradually. The pattern of flow rate and sialochemistry during recovery was essentially the same for all patients. In most subjects there was a residual effect an elevated sodium and chloride and a decreased phosphate relative to flow rate. The degree of change from normal appeared to be a good indication of residual pathology within the Bland Sialochemistry should be useful to the clinician in the diagnosis and treatment of chronic recurrent parotitis.

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1980.tb01391.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

AbstractThe granules from epithelium of filiform papillae of the dorsal surface of dog tongue were characterized as eosinophilic in contrast to the classically described basophilic keratohyalin granules which slain characteristically with hematoxylin. The eosinophilic granules also stained with Sakaguchi oxine reaction indicating the presence of arginine. At the ultrastructural level the round or oval granules varied in size and electron density. The granules were often associated with ribosomes and/or tonofilaments and were not limited by membranes. These granules disappeared in the superficial layers of epithelium which was parakeratotic in nature. Our studies indicate that the eosinophilic granules belong to the class of keratohyalin granules which are known to be heterogeneous in their morphology and biological composition.

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1980.tb01392.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

AbstractThe mucosal allograft offers a reproducible model for the characterization of the response of the oral mucosa to immunopathologic processes. Orthotopic allografts of oral mucosa or of skin were exchanged between pairs of unrelated rabbits known to be either matched or mismatched at the major histocompatibility locus (RLA). Rabbits with autografts of these tissues served as controls. The behavior of allografts of oral mucosa and of skin, although similar in many ways, showed marked differences in the morphology of the rejection reaction including more striking vascular damage and vascular occlusion in skin and in the longer persistence of granulocytes throughout the period of rejection in mucosal allografts. The rejection of matched allografts appeared morphologically similar to that of mismatched grafts but the time sequence was delayed. Morphological differences between the rejection reactions in allografts of oral mucosa and those of skin may result from differences in the expression of histocompatibility and tissue specific antigens in these tissues as well as other local factors such as the nature and distribution of mucosubstances of the connective tissue ground sub stance, the regional blood flow, and the absorption of salivary components including water in an oral wound.

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1980.tb01393.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

AbstractBoth check pouches of two groups of live male hamsters were treated with one application of either 50′% turpentine in liquid paraffin (TLP50) or a 0.5% solution of dimethylbenz(α)anthracene in liquid paraffin (DMBA); animals were killed 48 h later. Five untreated animals served as controls. Mucosal specimens were removed from each pouch, fixed in formal‐acetic‐alcoliol and processed for light microscopy. Sections were cut at 4 μm and stained with haematoxylin and eosin. A systematic random sampling method was used to obtain sections for Stereological analysis. Grids for point and intersect counting were superimposed on the projection screen of an automatic sampling microscope. Results showed that the epithelial nuclear‐cytoplasmic ratio, nuclear density, nuclear diameter and surface area interface ratios were similar for the experimental groups and, with the exception of the last parameter, differed significantly from controls. The volume proportion of TLP5O‐treated epithelium was significantly larger than that of DMBA‐treated epithelium. Derived values for the average nuclear volume in both experimental groups were almost twice that of controls; the cytoplasmic volumes were more than doubled. At 48 h the epithelial response to a single application of TLP50 or DMBA was essentially similar except that TLP50 probably induced greate

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1980.tb01394.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY