摘要:

Three types of stimulus, chemical, physical and viral, are known to be carcinogenic to susceptible animals. This review considers these stimuli and their possible mechanisms in general terms and their possible relevance to the induction of oral mucosal carcinoma in particular.

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1988.tb01524.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

A number of factors have been associated with the development of the phenotypic expression of neoplastic disease. The following article reviews the evidence implicating these factors in carcinogenesis and considers them under the groupings of familial or genetic factors, dietary factors, hormonal factors, age and gender.

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1988.tb01525.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

Deciduous teeth from 7 patients with dentinogenesis imperfecta (DI) Type I and Type II were examined by conventional microscopy. A defective layer was found which runs parallel with the dentinal surface in the outer portion of dentin in teeth of both types. Dentinal tubules were interrupted in the vicinity of this layer. When the ground sections were examined after being stained by the phosphophoryn staining method, the DI Type I dentin was found to contain phosphophoryn at the same low level as the DI Type II dentin, suggesting similar deficiency in phosphophoryn concentration. These results suggest that both types of DI have a common primary disturbance in the early stage of odontoblast differentiation.

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1988.tb01526.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

The course of reticular, papular, bullous, plaque‐type, atrophic and ulcerative lesions of oral lichen planus (OLP) was studied in 611 patients. Mean age of the patients was 53 years and two‐thirds were women. The patients were followed for periods from 1 to 26 years (mean, 7.5 years). The various clinical types had somewhat different courses. Papular affections were seen mainly in the initial phase and had a transitory course. Ulcerative lesions, although more persistent, also generally showed a short‐term course. The atrophic form was fluctuating with many remissions and new‐established affections. The plaque‐type was a more constant form, but also demonstrated many newly established affections. After a few years, many patients had persistent lesions that no longer included the affections most characteristic of OLP, i.e. the reticular and the papular form. Initial presence of papular affections was associated with ages below 50 and atrophic lesions with ages above 60. Plaque‐type affections were seen with a significantly higher frequency among tobacco smokers at the onset of OLP. No other correlation was found between the initial presence, the remission and the development of the different clinical forms and various factors as age, sex, general diseases, medication and tobacco smoking. Treatment with topical steroid and/or antimycotics had no effect on the long‐term course of the various clinical forms, and it had no persistent effect on symptoms related to OLP. Complete remission was seen in 17% of the patients, and it showed a reverse association with the initial presence of plaque‐type affections. However, complete remission was associated with an initial presence of papular affections. No other predictive factor of total remi

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1988.tb01527.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

The present report describes malignant development in oral lichen planus (OLP) among 611 patients (409 F, 202 M) followed for periods from 1–26 years (mean: 7.5). During follow‐up, 9 patients (1.5%), 8 women (1.9%) and 1 man (0.5%) developed oral squamous cell carcinomas (SCC) in areas of lichen planus lesions. The age of the patients at diagnosis of carcinoma ranged from 56–79 years (mean: 70.4) and the length of follow‐up before malignant development ranged from 4.9–24 years (mean: 10.1). The estimated number expected to develop oral cancer in a sample of the general Danish population of similar size, age distribution and follow‐up was 0.18 (0.11 F, 0.07 M) i.e., OLP cases showed a 50‐fold increase (F = 70‐ M = 14‐fold). The observed number of cancer cases was significantly higher than the estimated number (p<0.00001). Therefore, oral lichen planus fulfils the WHO criterion of a prema

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1988.tb01528.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

The clinical and histological features are described of 14 subjects with SF who had given up betel nut chewing. The typical clinical features of the disease: blanching of the mucosa, palpable fibrous bands and complaints of burning and dryness of the mouth were still present, even in subjects who had not practised the habit for as long as 13 years. The characteristic histological features of the disease: atrophy of the oral epithelium and extensive fibrosis of the lamina propria, which in some instances penetrated into the submucosa, also persisted.

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1988.tb01529.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

The binding pattern of antibodies against different cytokeratin (CK) polypeptides, tissue polypeptide antigen (TPA), carcinoembryonic antigen (CEA), lactoferrin (Lf), lysozyme (Ly) and secretory component (SC) in palatal glands (PSG) of long‐term denture wearing patients has been studied to investigate immunohistochemically the localization of these marker proteins in normal PSG and in denture‐induced sialadenitis of PSG. The study included palatal gland biopsies from 28 patients (15 f, 13 m; mean age 59 years), 17 of them with normal PSGs, 8 with focal obstructive sialadenitis, and 3 with diffuse sialadenitis. Presence of CK and TPA was found in all intra‐ and extraglandular salivary ducts, in the basophilic portions of acini, in some mucous acini, and in all atrophic acini. Increased expression of CEA and Lf was observed in inflammed areas of PSG which, on the other site, were devoid of Ly and SC. In the mucous acini of healthy PSG considerable basal Ly immunoreactivity was seen. SC was localized in almost all ductal cells and in some acinar cells. Appearance of Lf in the ductal cells of PSG indicates an early sign of palatal sialadenitis. Some distinctions in the expression pattern of the marker proteins between the mucous acini of major salivary glands and PSG point to differences in the functional activities of either group of salivary g

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1988.tb01530.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

Three calcifying epithelial odontogenic tumors (CEOT) were examined immunohistochemically. The localization of intermediate filaments was characterized through the use of polyclonal anti‐keratin antiserum (TK which detects 41–65 kd keratins), 2 monoclonal keratin antibodies (PKK1 specific for the 44, 46, 52&53 kd keratins and KL1, specific for the 55–57 kd keratins) and monoclonal antibodies for vimentin and desmin. The tumor epithelial cells were slightly positive or negative for PKK1 detectable keratins, but slightly to strongly positive for KL1 and TK antibodies. Tumor epithelium was slightly positive for vimentin but negative for desmin. The tumor foci were composed of both dark‐staining and pale‐staining cells; the former had a more intense reaction with KL1 and TK antibodies than the latter. Homogeneous acellular material was either PAS‐positive or negative, with or without calcification, and kerat

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1988.tb01531.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

The purpose of this study was to present a modified photometer based digital analysis system for image enhanced microradiographic semi‐quantitation of reactions of demineralization and remineralization of root surface lesions. The system was used to determine effects of fluoride on abraded root surface dentinin vitro.Lesions of 30–40 μm depth were produced during 18 h exposure of 180 μm thick single sections in solution of 3 mM Ca (Ca/P 1.67) and 30 mM lactic acid at pH 5.1. Mean mineral content of the lesions was 32% relative to adjacent sound dentin. Exposure of 20 h in the same acid with 5 mM Ca (Ca/P 1.67) and 0.12 mM NaF at pH 6.1 restored the mean mineral content to 76% of normal and increased the resistance of the lesions to demineralization. Remineralization and subsequent demineralization characteristics indicated the growth of fluorapatites on residual minerals in the dentin lesions. The microradiographic analysis system proved to be sensitive and critical in these st

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1988.tb01532.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

When epidermal (EFG) (10 ng/kg body wt) or nerve growth factor (NGF) (1 ng/kg body wt) was given intraperitoneally to sialadenectomized young rats (submandibular‐sublingual (SM‐SL) glands removed) prior to injection of isoproterenol (ISO) (50 mg/kg body wt), the inhibition of ISO‐induced thymidine incorporation into DNA of parotid gland and pancreas caused by removal SM‐SL glands was reversed, and thymidine incorporation of sialadenectomized ISO‐treated organs was as high as that of parotid and pancreas of surgically intact animals given ISO. EOF alone caused an increase in [3H] thymidine incorporation into DNA of parotid (63%) and pancreas (59%); removal of the SM‐SL glands caused a decrease of 57–70% in thymidine incorporation into DNA of parotid, pancreas, liver, lung, kidney, and spleen. A growth effect attributable to the EGF and NGF of the submandibular gland was thus apparent for all organs examined, but even if they had large complements of β1, adrenoceptors, only the exocrine organs showed the ISO‐induced β1, adrenoceptor response to EOF and NGF. EGF and NGF thus interact only with β1adrenoceptors of exocrine organs to cause marked increase in [3H] thymidine incorporati

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1988.tb01533.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY