摘要:

Aspergillosis, cryptococcosis and zygomyacosis (muconnycosis) are overall the most common systemic mycoses but histoplasmosis is particularly endemic in parts of central USA and other areas worldwide. Orofacial lesions caused by systemic mycoses have rarely been reported in the past though they have been recorded particularly in outdoor workers from geographic areas with a high prevalence of infection and occasionally in immunocompromised individuals. Increasing worldwide travel, and the dramatic increase in numbers of immunocompromised persons, especially those with human immunodeficiency virus (HIV) disease, have been responsible for an increase in reports and other studies of orofacial disease in systemic mycoses and new opportunists arc now being recognized. Those in Oral Medicine and Pathology must now be aware of the possibility of a systemic‐mycosis as the cause of chronic oral ulceration, chronic maxillary sinus infection, or bizarre mouth lesions, especially in patients with HIV disease, lymphoproliferative disorders, or diabetes mellitus, or in those who have been in endemic areas. Diagnosis and management should be undertaken in consultation with a physician with appropriate expertise, as pulmonary and other systemic infection may well be present. This paper reviews the eight main systemic mycose

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1992.tb01013.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

There are numerous reports of oral lesions in HIV‐infected individuals. However, few correlate the oral lesions with laboratory parameters. This study examined oral candidiasis and hairy leukoplakia, the two most common HIV‐associated oral lesions, in relation to T‐cell counts, p24 core antigen levels and salivary flow rates. Oral mucosal examinations, immunologic and virologic studies and stimulated whole and parotid saliva How rales were conducted on 135 (HIV+= 102, HIV‐ =33) homosexual or bisexual men. Results indicate that, among HIV‐infected subjects, the odds of having oral candidiasis is 6 times (95% CI = 0.6–56.6) greater for subjects with T4 counts between 200–399 per mm3, and 23 times (95% CI =2.8–193.0) greater for subjects with T4 counts less than 2007 mm1 compared to subjects with T4 counts of 400/mm3or greater. Subjects had an equal likelihood of having hairy leukoplakia at different levels of immunocompetence. The prevalence of oral candidiasis and hairy leukoplakia was higher among subjects with infectious virus in their serum, but was only statistically significant for hairy leuko

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1992.tb01014.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

The aggregation and adherence activity of P.aeruginosa, mediated by whole saliva from cystic fibrosis (CF) patients and non‐CF subjects, was investigated. CF saliva‐mediated aggregation of P.aeruginosawas stronger than the activity of non‐CF saliva. Likewise, P.aeruginosaadherence to buccal epithelial cells (BEC) of CF patients was stronger than to BEC of non‐CF subjects. Adherence of non‐mucoid P.aeruginosato BEC of CF patients was increased by saliva, whereas the mucoid variant was not. CF patients colonized with P.aeruginosashowed higher adherence of the non‐mucoid variant than non‐colonized CF patients. CF patients with high saliva‐mediated adherence of non‐mucoid P.aeruginosaalso had high salivary aggregation activity. Increased CF saliva‐mediated aggregation activity may be linked to the increased non‐mucoid P.aeruginosaadherence

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1992.tb01015.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

Many patients with advanced cancer have oral problems, some of which may have a microbiologic basis. The oral flora in such patients has not, however, been characterized. This study has assessed the prevalence of yeasts, coliforms and coagulasc positive staphylococci in the oral flora of 197 patients with advanced cancer. Both imprint cultures (n= 197) and oral rinses (n= 161) were collected. Yeasts were isolated from the mouths of 83% of the patients, coliforms from 49.1% and coagulase‐positive staphylococci from 28%. All these percentages are considerably in excess of reported levels for healthy individuals. The results indicate a loss of colonization resistance of the oral mucosa in terminal cancer, with potential implications for the development of mouth care regimes for such patient

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1992.tb01016.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

A retrospective study is reported of 14 cases of gingival cyst of adults. Clinical data were pooled with well‐documented cases in the literature. Most cases occurred in the 5th and 6th decades and in the premolar‐canine‐incisor area. Microscopically, the epithelial lining ranged from a thin, flat to cuboidal layer, 1‐3 cells thick, resembling reduced enamel epithelium, to a nonkeratinized stratified squamous epithelium without rete ridges, of about 5–6 layers. Epithelial cells were frequently atrophic and this could involve the full thickness of the epithelium leaving an amorphous band of eosinophilic material. Plaque‐like epithelial thickenings are sometimes present. Multicystic or “botryoid” forms may occur. The cysts are of developmental origin, arising either from basal cell extensions of overlying epithelium; or from postfunctional odontogenic epithelial residues of the dental lamina or rests of Malassez; or from junctional epithelium in the gingival crevice. The latter theory of or

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1992.tb01017.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

The expression of epidermal growth factor receptor (EGFR) was investigated in 67 cases of odontogenic cysts and 35 cases of odontogenic tumors using monoclonal antibody to EGFR (Biomarker, Israel) to determine the presence and significance of this transmembrane growth factor receptor. The cystic epithelial cells of odontogenic cystic lesions (keratocyst 60%: primordial cyst 75%; radicular cyst 35%; and follicular cyst 47.4%) were positive to EGFR staining. Cytochemical characterization of EGFR in those cystic epithelium was cell membrane positive type as in the normal epithelium. No expression of EGFR was found in the odontogenic tumors. This diversity of EGFR represents no binding activity of EOF, or loss of EGFR in the tumor cell upon EGFR mediated growth in odontogenic tumors was suggested a different tumor cell growth factor status or microenvironment in cell proliferation mechanism at the cellular level in cysts and tumors of odontogenic origin.

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1992.tb01018.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

The clinical, morphologic and immunohistochemical features of 10 cases of the low‐grade mucosa‐associated lymphoid tissue (MALT) lymphoma of salivary glands are described. Although the initial histologic diagnosis in nine of these cases was myoepithelial sialadenitis, the diagnosis of primary salivary gland MALT lymphoma was based on the demonstration of light chain restriction and on morphologic characteristics. Histologic study showed a characteristic cytology, which included centocytoid cells (composed of small centrocytes and monocytoid B cells) and a varying degree of plasma cell differentiation; the occurrence of epithelial or acinar invasion by neoplastic centrocytoid cells; and the presence of reactive lymph follicles among the neoplastic cells. Furthermore, multinucleate giant cells resembling Warthin‐Finkeldey cells were detected in seven cases. In the light of these findings, cases previously diagnosed as myoepithelial sialadenitis require careful assessment and nine out of 32 cases are, in reality, examples of primary salivary gland MALT lymphomas. Immunohistochemical analysis of paraffin sections revealed the following characteristic immunophenotype of Malt lymphoma: L26, KiB3 and LN2 positive, and a monotypic immunoglobulin pattern (predominantly IgM/K). It was of interest that salivary gland parenchyma, infiltrated by neoplastic centrocytoid cells, reacted with LN3 for cells expressing human leukocyte antigen‐DR (HLA‐DR) antigens. Whereas salivary gland epithelia devoid of a neoplastic invasion were invariably negative for LN3. This suggests a lymphocyte‐mediated role in salivary epithelial HLA‐DR expression. It appears that HLA‐DR expression is an inducible phenomenon in MALT lymphomas of

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1992.tb01019.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

In the present paper the 21‐yr experience of the Department of Oral and Maxillo facial Surgery and Oral Pathology, and the Department of Otorhinolaryngology of the Free University Hospital. Amsterdam, is reported with regard to the possible premalignant character of oral lichen planus. The study consists of two parts: 1) the follow‐up of 113 patients with histopathologically proven oral lichen planus, and 2) a search for lichen planus in 727 patients who have been admitted for oral cancer. Three patients with histopathologically proven lichen planus developed a squamous cell carcinoma in an average follow‐up period of 7 yr. In the 727 patients with oral cancer, two additional patients with the simultaneous occurrence of oral lichen planus were observed. Our experience gives some but not very strong support to the hypothesis that oral lichen planus is a premalignant cond

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1992.tb01020.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

Recent studies have suggested that the epithelial expression of two leukocyte‐related proteins, human class II HLA‐DR antigen and myelomonocytic LI antigen, depends on a certain state of cellular maturation and differentiation. We have studied HLA‐DR and LI expression in oral squamous cell carcinomas. The epithelial distribution of these proteins was evaluated in relation to differentiation alterations by two‐color immunotluorescence staining with cytokeratins (KI4 and K13) as a baseline. HLA‐DR was infrequently expressed in oral carcinomas, apparently being unrelated to the degree of differentiation and the subepithelial leukocyte infiltration. LI was generally present in oral epithelium but disappeared in the most invasive cells of carcinomas. These cells were also KI4 and KB negative suggesting an abnormal state of differentiation. LI has been suggested to have an inhibitory effect on casein kinases I and II, enzymes possibly associated with cell proliferation; it might therefore exert an inhibitory effect on tumor growth. Its absence could be an interesting aspect of the invasiveness of oral carcin

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1992.tb01021.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1992.tb01023.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY