摘要:

The correct interpretation of cell kinetic data for normal epithelia requires a consideration of several interrelating factors. In abnormal states, such as leukoplakia, the lack of appropriate data for these parameters makes such interpretation difficult. Consequently, an altered mitotic index need not indicate an abnormality of cell proliferation.

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1981.tb01289.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

A mandibular lesion from an infant with Letterer‐Siwe disease was studied by electron microscopy and immunohistochemistry. Ultrastructurally, two types of cells were identified; clear and dark cells. Clear cells had indented nuclei and Langerhans cell granules, while dark cells were characterized by the occasional presence of a large number of lysosomes. Lysozyme was usually not detectable in proliferating cells with indented nuclei, but it was strongly positive in cells without indented nuclei. The latter also usually contained IgG, although the occurrence of cytoplasmic IgM, A, D and E seemed to be negative in both types of cells. Thus clear cells showed a close resemblance to Langerhans cells and dark cells had features of ordinary histiocytes. Although the intimate relationship between these two types of cells remains obscure, our findings suggest that Letterer‐Siwe disease may be a reactive or tumorous condition of a cellular subpopulation of Langerhans cells with a proliferation of differentiated histiocy

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1981.tb01290.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Twenty‐seven patients (19 females and 8 males) with a clinically diagnosed desquamative gingivitis were used in this study. Twenty‐seven additional patients with oral and skin diseases and with gingival involvement other than that of the de‐squamative gingivitis type served as controls. Biopsy gingival specimens were sectioned and stained with H and E. The rest of the tissue specimen was cut with a cryostat and used for immunofluorescent assays of the tissue‐bound antibodies (IgG, IgA, IgM, C3 and fibrin). Circulating antibodies were determined by using the indirect immunofluorescence method in serum samples. Normal human oral mucosa and several animal epithelial tissues were used as substrates. The immunopathologic findings suggest the diagnosis of lichen planus in the presence of linear or granular fibrin deposition at the basement membrane zone/mucosal submucosal interface with or without cytoid bodies and cicalricial pemphigoid, in the presence of circulating and/or tissue‐bound immunoglobulins and C3 in a linear continuous pattern along the BMZ. It is suggested that an accurate diagnosis of the underlying disease of the desquamative gingivitis can be made on the basis of the clinical, histopalhologie, immunopathologic and follow‐

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1981.tb01291.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

The carcinogen 4NQO was applied to the palates of rats for 2 weeks or 2 months. Eight weeks after termination of carcinogen application, animals were injected with colchieine and sacrificed at intervals of 3 h during a 24 h period. Histological sections were produced and the number of arrested metaphases counted in the palatal epithelium. The two groups had the same daily mitotic rate and exhibited a circadian rhythm in mitotic activity similar to that demonstrated in normal oral mucosa of nocturnal animals. Carcinogen was applied to the palates of other groups of rats for 2 weeks or 2 months. Animals treated with saline served as controls. At various time points during and after carcinogen treatment eight rats from each group were killed. Four of these animals were injected with colchieine prior to sacrifice and the number of arrested metaphases counted in the palatal epithelium. In the noncolchicinized rats all mitotic phases were counted. After cessation of carcinogen application the mitotic rates, the mitotic counts and the mitotic durations did not differ from those of control animals, indicating that the carcinogen had failed to induce irreversible changes in the cell population kinetics of the palatal epithelium.

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1981.tb01292.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Fresh and fixed tissue from a resection specimen of a calcifying epithelial odontogenic tumour (CEOT) was prepared for histological, histochemical, immunological and biochemical investigation in order to study the nature of the amyloid‐like material. The fixed tissue gave positive reactions with Congo‐red, Thioflavin T and the dimelhylamino benzene (DMAB)‐method for tryptophan. The diazotization‐coupling (DC) method for tyrosine was negative.The major protein purified from the unfixed tissue by sequential gel filtration had a molecular weight of 9,800. The amino acid analysis of this protein had similarities with tuft enamel protein, immune amyloid and the variable light chain component (VK).From the data obtained in this study, it is not possible to determine the precise nature of the amyloid‐like material in this CEOT. However, the results do support the concept that ‘amyloid’ should be considered as a term describing a broad group of rel

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1981.tb01293.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Hitherto, the effect of zinc deficiency on the rat parotid gland was not known. Male rats were fed cither a low zinc diet (0.4–0.8 ppm Zn) or a zinc adequate diet (approximately 40 ppm Zn) for 35–42 days. The experimental animals exhibited retarded body growth, anorexia, loss of hair and decreases in plasma and hair zinc levels. In comparison to the ad libitum controls, the parotid glands of the pair‐fed group showed a decrease in cell number, but an increase in cell mass, protein and amykisc content. In the parotid glands of the experimental group, cell number was comparable to the pair‐fed group, but there was a decrease in cell mass and protein content as compared to the pair‐fed group. These findings suggest that zinc deficiency and its associated reduced food intake impair growth of the parotid gland and, further, that zinc deficiency per se appears to lead to a diminution in gland protein synthesis. It is proposed that a compromise in parotid gland function could be a contributory factor underlying the increased susceptibility to dental caries known to occur in zinc d

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1981.tb01294.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1981.tb01295.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1981.tb01296.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Books reviewed in this article:Tooth Surface Interactions and Preventive Dentistry, eds. Rølla, G., Sønju, T.&Embery, G.Biomedical Research Applications of Scanning Electron Microscopy. Vols. 1 and 2, eds. Hodges, Gisele M.&Hallowes, Richard C.Epilepsy and the Oral Manifestations of Phenytoin Therapy, ed. Thomas M. HassellHistological Methods and Terminology, In Dictionary Form, by Frances M. Brimmer, H. T. (ASCP)Differentiation of Human Oral stratified Epithelia, by Hubert E. Schroed

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1981.tb01297.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY