ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1981.tb01279_10_5.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1981.tb01280.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1981.tb01281.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1981.tb01282.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

The effects of fractionated X‐irradiation following isoproterenol (1PN) administration on rat parotid gland were studied 4, 8, and 12 weeks post‐irradiation. Degenerative and necrotic changes of the acinar cells were observed at all three time intervals as a result of the radiation. These changes were more obvious 4 and 8 weeks post‐irradiation and isoproterenol administration. The necrotic acinar cells were replaced by fibrous connective tissue, especially conspicuous at 12 weeks. Reparative changes were observed along with the degenerative and regressive phenomena of the gland. Enlarged acinar cells and nuclei were observed as early as 4 weeks post‐irradiation. This change was locally distributed at the 4–week interval but more widespread 8 and 12 weeks post‐irradiation. Mitochondria! hyperplasia with alteration of mitochondria! cristae was observed 12 weeks post‐irradiation. Proliferation of cells of ductal origin and nodular proliferation of ducts were observed 12 weeks after isoproterenol administration plus X‐irradiation. These proliferative phenomena may represent an early stage of tumor formation resulting from the combined effect of isoproterenol and X‐irradiation on

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1981.tb01283.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Thrice weekly applications of DMBA to hamster ventral lingual mucosa, preceded by scratching with a barbed broach, led to tumor development in over 75% of the animals by 28 weeks. Macroscopic ulceration did not appear to be a necessary precursor of epithelial malignancy in this model. Tumors were preceded by a phase resembling human leukoplakia. In addition to developing tumors in the treated area, 60% of the hamsters developed tumors in the floor of the mouth or the area of mucosa on either side of the median lingual fraenum.

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1981.tb01284.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Stereological techniques have been used to quantify some morphologic aspects of non‐neoplastic and preneoplastic hyperplasia in hamster tongue. Scratching hamster ventral lingual mucosa and applying acetone thrice weekly resulted in moderate epithelial hyperplasia in biopsy material removed at 16 weeks. There was a significant increase in the number of progenitor cells per defined histologic field and a striking increase in the number of progenitor cells related to each unit of surface length. There was a small but significant increase in basement membrane length. In the experimental group in which the ventral lingual mucosa was scratched and painted with 0.5% DMBA in acetone there was pronounced epithelial hyperplasia with increases in the thickness of the progenitor, maturation and keratinized compartments. Progenitor cells showed hyperplasia and hypertrophy. The number of progenitor rolls related to each unit of surface length was significantly greater than normal or control values. There was a significant increase in the basement membrane length per field, reflecting an increased folding and prominence of the rete ridge

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1981.tb01285.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

An experimental model in the white rat has been developed in order to study the influence of snuff on oral mucosa. A test canal in the lower lip, with one orifice buccally to the incisors and one on the lip side, was created by surgical means. The connection between the canal and the oral cavity was made to ensure the presence of saliva in the canal so that physiological conditions resembling those of the oral cavity were obtained. The canal was filled with snuff morning and night 5 days a week. The mean value for the maximal retention time of the snuff was 6 h. The animals tolerated the dose and time of exposure without signs of severe toxic symptoms. Histological examination of the canals after 9 months of exposure to snuff showed a mildly to moderately hyperplastic epithelium with hyperorthokeratosis. Locally deep proliferations of epithelium with acanthotic rete pegs could be seen. In the stratum basale hyperplasia with disturbed polarity and hyper‐chromatic nuclei and single mitosis were note

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1981.tb01286.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Scrum β2microglobulin concentrations measured by radioimmunoassay in patients with oral squamous cell carcinoma, or with oral keratosis and epithelial dysplasia, were found to be significantly increased compared with age and sex matched controls

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1981.tb01287.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1981.tb01288.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY