摘要:

AbstractEarly attempts to induce malignant oral tumours were largely unsuccessful, us the oral mucosa is considerably more resistant to the actions of chemical carcinogens than skin. The first consistent success came when strong carcinogens were applied to the hamster cheek pouch. This model remains the most popular for studies of intra‐oral carcinogenesis and is discussed at length. The advantages and disadvantages are critically reviewed. The models of intra‐oral carcinogenesis in extra‐pouch sites in the hamster, mouse, rat and nonhuman primates arc considered. The possible reasons for the relative resistance of oral mucosa to chemical carcinogens are discussed, particularly in relation to portals of entry and saliva. Finally, the relative merits of the more popular models of intra‐oral carcinogenesis are briefly di

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1981.tb01259.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

AbstractHyaline bodies are sometimes encountered in the connective tissue wall of odontogenic cysts. In this study, various histomorphologic types of hyaline bodies were observed in a dentigerous cyst and a residual apical periodontal cyst. Some hyaline bodies appeared to be a coagulum of serum fluid surrounded by a small number of fibroblasts. Others appeared to be composed of fibrillar structures. Still others appeared to be a mixture of various amounts of scrum coagulum and fibrillar structures. Immunoperoxidase procedures revealed various amounts of scrum proteins in hyaline bodies. Gomori's trichrome stain and Mallory's staining technique showed that fibrillar structures were collagenous in nature. Electron microscopy showed that fibrillar structures were frayed collagen fibrils. These observations suggest that various histologic types of hyaline bodies represent different stages of development and that the basic pathogenic mechanism is pooling of extravasated serum followed by fibrosis.

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1981.tb01260.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

AbstractA case of cellular pleomorphic adenoma of the parotid gland was studied by electron microscopy. The tumor contained stromal masses of 8‐nm filaments that were identified as amyloid. None of the surrounding cells contained amyloid fibe

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1981.tb01261.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

AbstractAn increased nuclear‐cyloplasmic ratio is one of the cytological features of epithelial alypia taken into account when the histopathologist subjectively assesses whether an epithelial lesion is likely to become malignant. The present work evaluates this ratio ultrastructurally in the DMBA‐treated hamster cheek pouch model with a view to assessing whether alterations of this feature represent a valid indicator of malignant transformation. Following DMBA treatment, lesions obtained were assigned to three defined histopathological categories, namely epithelial hyperplasia, epithelial dysplasia and squamous cell carcinoma. Untreated pouches served as controls. Electron micrographs were obtained of basal, spinous and granular layer cells from each of these categories and the N/C ratio was evaluated using stereological point counting techniques. The results indicated that progressive decreases in the ratio occurred in all pathological stages during differentiation (i.e., between basal and granular cells). During carcinogenesis there was a tendency for the ratios to decrease in each cell layer but significant differences were not detected between normal and premalignant lesi

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1981.tb01262.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

AbstractBone resportion (gangrenous stomatitis) was found to be associated with extensive bacterial colonization of mandibular bone in three separate cases of noma. Light and electron microscopy revealed a heterogeneous bacterial population with a long, filamentous, Gram‐positive organism predominantly in direct contact with the resorbing bone front. The bone was completely denuded and no osteoclastic activity was observed. The highly regular arrangement of the filamentous organism along the resorbing bone and the absence of osteoclastic activity suggested that bone resorption in noma is mediated by bacterial actio

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1981.tb01263.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

AbstractHuman oral epithelial lesions showing epithelial dysplasia were contrasted with hamster cheek pouch lesions induced by DMBA using the Smith&Pindborg (1969) technique for epithelial atypia scoring. It is concluded that the histological features of dysplasia in the hamster are closely similar to human lesions.

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1981.tb01264.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

AbstractCytoplasmic crystalloids were found in paroid aeinar cells of rats given a large (6400 R) single exposure of X‐rays to the head and neck. The crystalloids were first observed 1 day after irradiation and became numerous at 3–4 days. They were associated with autophagie vucuoles, which were seen in acinar cells as early as 3–6 h. Crystalloids sometimes appeared to be forming within autophagic vacuoles, which also contained membranous residues and apparently degenerating secretory material. They were bounded by a single, smooth membrane and had a substructure consisting of dense, parallel longitudinal striations. The crystalloids were also seen in macrophages associated with the basal surfaces of acinar cells. At 3–4 days macrophages were numerous and many contained crystalloids, degenerated secretory droplets, and other cellular debris, which they apparently had phagocytosed. By 6–8 days crystalloids and macrophages were seen infrequently. Regarding mode of formation, removal by macrophages, and ultrastructure, the crystalloids resembled those described by others after ethionine intoxication. Ethionine‐induced crystalloids have cytochemical characteristics consistent with a lysosomal identity. The crystalloids in irradiated parotid glands probably reflect a variant type of lysosome, which is a nonspecific manifestation of severe cellular injury and can be elicited by a variety of injur

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1981.tb01265.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

AbstractDistinction between lesions of the jaws containing giant cells can be difficult. This study reports the results of the study of the ultrastructure of 30 patients with Paget's disease in comparison with a patient diagnosed as having malignant giant cell tumor of the mandible. The ultrastructure of the malignant giant cell tumor of the mandible was found to contain nuclear inclusions morphologically identical with the 12–15 nm tubules characteristic of the nuclei of osteoclasts in Paget's disease of bone. No clinical or laboratory signs of Paget's disease were found in this patient. A search of the literature failed to produce reports of identical nuclear inclusions in soft tissue giant cell tumors, osteosarcomas, reparative granulomas containing giant cells or in osteitis fibrosa eystica. Such nuclear inclusions have been reported in benign giant cell tumors of bone, one other in malignant giant cell tumor and cases of polymyositis. These observations raise the question of a possible virus associated with the tumor since there arc recent reports of immunological evidence for the presence of a virus in Paget's disease, and viruses have been suspected in polymyositi

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1981.tb01266.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

AbstractOf 65 intraoral salivary gland tumors received by the Department of Pathology, Dental Faculty, University of Oslo between 1957 and 1979, 13 (20%) were diagnosed as adenocarcinomas. A study of available clinical data and histologic features indicates that these are slow‐growing neoplasms which metastasize lat

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1981.tb01267.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY

摘要:

Books reviewed in this article:Dermatology in Gerneral Medicine, eds. T. B. Fitzpatrick, A. Z. Eisen, K. Wolff, I. M. Freedberg&K. F. Austen, 2nd edn.Natural Cell‐Mediated Immunity against Tumors, ed. Ronald B. HerbermanBehçet's Syndrome: Clinical and Immunological Features, eds. Lehner, T.&Barnes, C. G.The Physiology and Pathophysiology of the Skin, Vol. 6, ed. Jarrett, A.Manual of Clinical Microbiology, 3rd edn., eds. Lennette, E. H., Balows, A., Hausler, W. J. Jr.&Truant, J. P.Immunochemical Methods in the Biological Sciences: Enzymes and Proteins, Mayer, R. J.&Walker, J. H.Electron Microscopy in Human Medicine, Vol. 1: Instrumentation and Techniques, ed. Jans Vincents JohannessenDer Mundhöhlenkrebs und seine Vorstadien: Ultrastrukturelle und immunpathologische Aspekte (Oral Cancer and Precancer: Ultastructural and Immunipathologic Aspects), Arne BurkhardtDental Plaque and Surface Interactions in the Oral Cavity, ed. Leach, S. A.Immunology of Oral Diseases, by I. M. Roitt and T. Le

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1981.tb01268.x

出版商:Blackwell Publishing Ltd    

年代:1981

数据来源: WILEY