ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1988.tb01892.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1988.tb01893.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

Oral pulse granuloma is one of the terms used to describe oral inflammatory lesions characterized microscopically by the presence of giant cells and hyaline rings. The various names proposed for these lesions reflect the lack of agreement regarding their pathogenesis. One theory advanced claims that the process represents a foreign‐body granulomatous reaction to implanted vegetable particles, more specifically those of pulses/legumes. In this study an animal model was developed where homogenized cooked legumes were implanted into the orofacial region of rats. Animals were killed at varying intervals ranging from one day to six months and the tissues associated with the implanted material were removed and processed for light microscopy. The experimentally produced lesions had many features similar to those found in humans, the similarities becoming more pronounced with time. The results indicate that the cellulose moiety of food particles of plant origin accidentally implanted into human tissues may cause the granulomatous reaction known as oral pulse granulom

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1988.tb01894.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

Vitamin A affects epithelial differentiation and growth via at least 3 different binding proteins. The specific delivery of extracellular retinol to target cells is performed by plasma retinol‐binding protein (RBP) while cellular retinol‐ and retinoic acid‐binding proteins (CRBP and CRABP) are implicated in the cellular action of the 2 natural retinoids. We have studied the levels of these 3 binding proteins by gel filtration and polyacrylamide electrophoresis in human oral mucosa, epithelium and chorion and compared it to those found in keratinizing human epidermis. The levels of CRABP in oral epithelium were markedly higher (about 4 times) than that of epidermis whereas CRBP was in a similar amount in epithelium chorion, dermis and epidermis. RBP with preserved affinity for retinol, was present in the epithelium of oral mucosa whereas only degraded RBP was detected in epidermis. These results suggest (i) a higher specific retinol delivery and (ii) a distinct cellular metabolism of retinoic acid in the oral epithelium as compared with epidermis. Since cornification occurs when keratinocytes are deprived of retinol, it might be that our observations are linked to the absence of cornification in the human oral mucosa. Further, high levels of CRABP in mucosal epithelium might have therapeutical implications because the synthetic retinoids used in human therapy bind to

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1988.tb01895.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

An NIH conference on “Removal of Third Molars” debated the need for removal of asymptomatic impacted teeth with no evidence of pathology but stressed the need for long‐range studies. The assumption is that “neglected” impacted third molars (ITMs) will sometime cause serious pathology. Examination of panoramic radiographs of 11,598 patients revealed 1,756 patients with 3,702 impacted teeth; average age 47 years, and an average retention period approximately 27 years. Dentigerous cystic changes occurred in about 30 ITMs (0.81%), internal resorption in 16 (0.43%), periodontal ligament damage and bone loss distal to the 2nd molar 166 times (4.48%), and pressure resorption of the 2nd molar 113 times (3.05%). No great surge in pathology occurred with increasing age. Some type of pathological change can be expected eventually in approximately 12.0% of an impacted 3rd molar population and 1.82% of the general population. A reappraisal of routine removal of ITMs might be

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1988.tb01896.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

The presence of HNK‐1 (Leu‐7)‐positive cells and natural killer (NK) cell activity was determined in human periodontal tissues. Gingival tissues obtained from 25 adult patients were processed for analysis utilizing a HNK‐1 (Leu‐7) mouse monoclonal antibody. A subpopulation of non‐adherent lymphoid cells obtained by collagenase digestion of inflamed gingival tissues from 10 patients was examined for the presence of large granular lymphocytes (LGL) by May‐Grünwald‐Giemsa staining and for NK cell activity against K562 cells by a51Cr release cytotoxicity assay. HNK‐1+cells were identified in gingival tissue sections of 21 patients, and were present in or close to discrete foci of plasma cells. HNK‐1+cells were scarce in mildly inflamed or uninflamed tissues sections. LGL were identified in 9 of 10 gingival single‐cell suspensions and constituted approximately 5% of the gingival cell population. NK cell‐mediated cytolysis, at varying effector/target cell ratios, was observed for 3 of 4 enriched gingival mononuclear cell populations. Gamma‐interferon (INF‐γ) preincubation of enriched gingival effector cells from 5 additional patients resulted in a 43% increase in NK cell activity. The finding of increased HNK‐1+cells with gingival inflammation suggests that these cells may play a role in tissue damage, as well as in modulation of B cell activity, in gingivae of pa

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1988.tb01897.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

Calcifications found in the coronal pulps of primary teeth extracted in an 8‐year‐old child were studied by TEM. Different types of relationship were observed between fibroblasts and pulp calcifications: extension of cell processes towards calcifications, modelling of the cells upon calcifications, internalizing process of calcifications. Fibroblasts proved to be able to enclose small pulp calcifications within intracytoplasmic vesicles. There was no evidence of any active role played by fibroblasts in the genesis of pulp calcifications. It was shown that collagen fibres could be involved or not in the mineralizing process. It is suggested that mitochondria might provide an adequate environment for initial mineralization. It is likely that the role played by the cytoskeleton in the internalizing process of calcifications is import

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1988.tb01898.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

Anin vivocomparison was made between the contact allergic stomatitis‐inducing capacity of nickel, nickel‐containing dental alloys and a non‐corrosive precious metal. Fifteen patients with a positive allergic skin reaction to nickel were divided into 3 groups (A, B and C). The patients in Group A (n=4) were fitted with an intra‐oral corrosion‐resistant nickel‐chromium Alloy A; the patients of Group B (n=5) received a more corrosion prone nickel‐chromium Alloy B and in Group C (n=6) strongly corroding pure nickel was used. A corrosion‐resistant foil of pure palladium was placed on the contralateral side. Reactivity of pure nickel foil was also tested on the skin in Group C. Immunohistological examination of the oral mucosa on the test and reference sides was performed with monoclonal antibodies directed against T‐lymphocyte subsets and Langerhans cells (LC). The results showed that at the pure nickel site the LC did increase significantly in the connective tissue (approx. 4×) of the oral mucosa. However, statistical analysis of all 6 patients of Group C together showed no corresponding increase of LC in the epithelium at the site with the pure nickel, although a numerical increase of LC was noted in the epithelium adjacent to the pure nickel foil in 2 patients, which was remarkable. It can be concluded from statistical analysis that both the reference foils and the test foils can influence the number of suppressor/cytotoxic T‐lymphocytes in the connective tissue. The results showed also that pure nickel can cause a strong infiltration of helper/inducer T‐lymphocytes, especially in the connective tissue. This infiltration of T‐lymphocytes and LC was not observed on the reference sides or on the test sides with the nickel‐containing foils in Groups A and B. It could be concluded that neither clinically nor immunohistologically is the presence of high percentages of nickel in the nickel‐containing dental alloys necessarily associated with allergic contact stomatitis

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1988.tb01899.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY

摘要:

Epithelial dendritic cells (EDC) were examined during the induction and growth of oral squamous cell carcinomas in rats treated with the carcinogen 4‐Nitroquinoline N‐oxide (4NQO). Acetone‐fixed frozen sections of the palate and tongue were stained using an indirect immunoperoxidase technique and a monoclonal antibody to rat la (MRC OX‐6). After 6 months there was a significant increase in Ia+EDC/mm2in non‐invasive palatal and lingual epithelium compared with untreated and solvent painted controls. Furthermore, after 9 months there were significantly more Ia+EDC/mm2in non‐invasive lingual epithelium compared with invasive epithelium or the epithelium overlying/adjacent to squamous cell carcinomas of the tongue. Although there were no significant differences of Ia+EDC/mm2between infiltrating epithelium of lingual carcinomas and non‐invasive epithelium overlying/adjacent to the tumour, these tissues did contain significantly more Ia+EDC than lingual epithelium from either solvent‐only or untreated controls. The results indicate that treatment with 4NQO stimulates an increase in Ia+EDC numbers which, although remaining higher than in controls, is not maintained within, or adjacent to, sites of ne

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1988.tb01900.x

出版商:Blackwell Publishing Ltd    

年代:1988

数据来源: WILEY