摘要:

Abstract.Ten‐day‐old mouse teeth were grafted subcutaneously into adults of an unrelated strain which were either untreated or had rejected a skin graft from the same strain as the tooth donors. First set allografts degenerated rapidly after grafting and were only sparsely repopulated subsequently. No cell‐mediated Immune response was observed. In contrast, second set allografts were heavily infiltrated with mononuclear leukocytes which persisted throughout the study, although the coronal pulp was never involved. It was suggested that first set allografts did not suffer a cell‐mediated response because rapid degeneration of the cellular components removed the immunogenic target tissue before the host response could be e

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1975.tb01740.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

摘要:

Abstract.Human biopsy specimens from white patches on the mucosae of tongue and lips which had previously given positive cultures forCandida albicanswere examined. The specimens were processed for electron microscopy by conventional techniques.The fine structure of the superficial layer of the epithelium revealedCandida albicansin extra‐ and intracellular sites. Penetration into the deeper layers was not observed. The fungus had a thick cell wall surrounded by an outer floccular layer. The cytoplasm of the superficial epithelial cells showed degenerative changes and fragmentation of tonofilaments in the immediate vicinity of the fungus. Microabscesses, formed by pools of neutrophils, were common in the upper spinous layer. In places, fungi and bacteria appear to have been phagocytosed by neutrophils and macrophages. The cells of the lower spinous and basal layers showed detachment of desmosomes, marked increase in intracellular glycogen, prominent lysosome‐like dense bodies and abundant mitochondria of differing shapes. At the epithelial‐connective tissue junction, fine filaments and collagen fibrils were intermingled throughout the basal lamina, forming multiple, highly electron‐dense layers. A noticeable change in the connective tissue was the accumulation of numerous mast cells containing differently shaped granules filled with scrolls and dense strands of granular material. The terminal blood vessel exhibited leakage and numerous, concentric duplications of the basal

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1975.tb01741.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1975.tb01742.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1975.tb01743.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1975.tb01744.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1975.tb01745.x

出版商:Blackwell Publishing Ltd    

年代:1975

数据来源: WILEY