摘要:

The effect of cigarette smoking on the oral mucosa was assessed through the application of quantitative cytomorphometric analysis to smears obtained from clinically normal buccal mucosa. The nuclear (NA) and cytoplasmic (CA) area of cells within each smear were measured using a Vids V semi‐automatic image analysis system. Mean values for NA (smokers – 78.74 μm2, non‐smokers – 72.28 μm2and for CA (smokers – 3273.9 μm2, non‐smokers – 3098.96 μm2) were obtained. A two‐sample t‐test revealed a significant elevation in NA for smokers, but no significant variation in CA between the two groups. These results would suggest that for normal buccal mucosa smoking does appear to inf

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1990.tb00795.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

Lactate dehydrogenase (LDH; EC 1.1.1.27) isoenzymes in human epithelial cells from squamous cell carcinomas and healthy tissues of the oral cavity of five patients were analyzed using isoelectric focussing. A new basic isoenzyme and high LDH‐7 and LDH‐9 activity were found in tumor cells in contrast to epithelial cells of adjoining nontumor tissue. These findings indicate that gradual changes in the percentage distribution of LDH isoenzymes may represent a useful parameter of disease activity in patients with squamous cell carcino

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1990.tb00796.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

Eighty young adult male Syrian hamsters were divided into four equal groups. Group 1 animals had the right buccal pouches painted with a 0.1 % solution of 7,12 dimethylbenz(a)anthracene (DMBA) three times per wk for 28 wk. Group 2 animals were similarly painted with DMBA for 28 wk but were also given 140 μg vitamin E in 0.4 ml mineral oil three times weekly on days alternate to DMBA painting. Group 3 animals were used as DMBA‐vehicle controls. Group 4 animals were vitamin E controls. Animals were killed after 28 wk, the pouches photographed and tumors counted, measured. The pouches were fixed in formalin, sectioned in paraffin and studied histologically and histochemically for tumor necrosis factors alpha and beta. All animals in Group 1 and 3 had gross tumors of the right buccal pouch. None of the animals in Group 2 had grossly visible tumors. Microscopic studies revealed that, while no gross tumors were seen in the Group 2 animals, there was histologic evidence of dysplasia and early carcinoma‐in‐situ undergoing degeneration. Immunohistochemical staining revealed a dense infiltrate of mononuclear cells adjacent to tumor sites with a large number of cytotoxic T lymphocytes and macrophages. Vitamin E appears to prevent tumor formation by stimulating a potent immune response to selectively destroy tumor cells as they begin to develop into recognizable microscopic foci of car

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1990.tb00797.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

The dental histopathology is described of patients suffering from Familial Expansile Osteolysis (FEO), a rare and unique autosomal dominant disease which has severe bony as well as dental consequences. The predominant dental features are resorption of the cervical and apical regions of the roots, premature depositions both of irregular secondary dentin, which causes narrowing of the pulp cavities, and of cellular cementum, which causes patchy narrowing of the periodontal ligament. The dental pulp shows age‐like changes, including multiple pulp stones and the ligament vasculature appears to be abnormal. Evidence for involvement of enamel is equivocal. This combination of dental effects together with the bony lesions distinguishes the disease from idiopathic external resorption of either the single or multiple kind, despite similarities in the histopathology of the resorptive lesions; and from other non‐hereditary and hereditary osteolytic disea

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1990.tb00798.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

Oral ulcerations associated with disseminated Cytomegalovirus (CMV) infection were observed in four patients with AIDS manifestations showing low CD4 counts. Virus cultures of urine and saliva samples were positive for CMV in all cases. The lesions were characterized by a punched‐out appearance, non‐indurated borders, low bleeding tendency and lack of inflammatory wall. Light microscopy revealed granulation tissue containing “owl's eye” like cells in all specimens. Presence of CMV was confirmed by immunohistochemistry andin situhybridization. The ulcerations were infiltrated with T‐lymphocytes of the helper, suppressor and cytotoxic subset, most were positive for HLA DR. Despite the local invasion with immunocytes and high serum titers of serum antibodies the patients experienced progressive CM

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1990.tb00799.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

The macro‐ and microanatomy of the marginal tongue mucosa were studied. Tissues were harvested from 12 individuals at autopsy. Random sections from six different locations along the margin and serial sections representing three defined section planes to the margin of the tongue were evaluated. Vertical, parallel mucosal folds alternating with shallow grooves were a characteristic macroscopical finding on the lateral border of the tongue. The mucosa presented a non‐keratinized epithelium with PAS‐positive, lightly stained spinous cells and no or slight inflammatory reaction in the connective tissue. Changes in the epithelium mimicking hyperplasia, acanthosis, keratin projections, and focal parakeratosis could be produced by changing the direction of tissue sectioning. The macro‐ and microscopical parameters recorded in normal marginal tongue mucosa are among others included in criteria for diagnosing oral hairy leukoplakia. The results emphasize the importance of a thorough knowledge of the normal anatomy of a mucosal site to arrive at reliable diagnostic c

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1990.tb00800.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

The numbers of CD1, HLADR, HLADP and HLADQ positive, intraepithelial, dendritic cells were compared in lesions of oral lichen planus and normal oral mucosa using an immunoalkaline phosphatase technique. In normal mucosa, there were equal numbers of CD1 and HLADR positive cells but significantly fewer cells were positive for HLADP (P>0.001)) and HLADQ (P<0.05). In lichen planus, the cells appeared more dendritic and equal numbers of CD1, HLADR, HLADP and HLADQ positive cells were found, with significantly more HLADP (P<0.01) and HLADQ (P<0.05) positive cells than in normal mucosa. There was no change in the number of CD1 and HLADR positive cells. These results show that although there is no change in the total number of Langerhans cells (CD1 positive cells) in lichen planus, there is an increase in Class II major histocompatibility antigen expression. This suggests that in lichen planus, Langerhans cells are immunologically active and play a role in lesion development.

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1990.tb00801.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

The eosinophil density in various tissue compartments in oral mucosal lichen planus and oral mucosal lichenoid drug reactions was studied using a variety of staining methods and histomorphometry. No significant differences were found, indicating that the presence of eosinophils cannot be used as a reliable histologic criterion for establishing a diagnosis of oral musocal lichenoid drug reactions.

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1990.tb00802.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

The purpose of the present investigation was to describe the formation, maturation and eruption of the dentition, including supernumerary teeth in a sample of patients with cleidocranial dysplasia. The dentition was evaluated from orthopantomograms, intraoral radiographs, cephalometric films, surgically removed teeth and intraoral photographs in 19 patients (9 men, 10 women), aged 3.5 to 34 years.Formationof primary teeth was normal, whereas all patients but one had supernumerary permanent teeth. Frequency of supernumerary teeth ranged from 22% in the maxillary incisor region to 5% in the molar regions. Supernumerary teeth were formed lingually and occlusally to the normal teeth.Maturationof the primary dentition was normal, while permanent teeth were delayed from 1 to 4 yr. Supernumerary teeth were delayed about 4 years in relation to normal permanent teeth.Eruptionof primary teeth was normal, whereas all patients had severe eruption problems of permanent teeth. It was hypothesized that the dental lamina for both primary and permanent dentition is normal, but does not resolve completely and therefore may form supernumerary teeth. Abnormalities of tooth morphology is related to inadequate space and arrested eruption. Delayed or arrested eruption is probably caused by diminished resorption of bone and of primary teeth and to the presence of multiple supernumerary teeth.

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1990.tb00803.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY

摘要:

A case‐control study to elucidate the etiology of oral submucous fibrosis was conducted in Bhavnagar, Gujarat. Sixty consecutively arriving oral submucous fibrosis patients at a dental clinic were selected as cases. An equal number of controls matched for age, sex, religion and socioeconomic status were selected from individuals who did not exhibit any oral mucosal lesion or condition. Among cases, 98% chewed areca nut regularly in one form or the other whereas among controls 35% chewed areca nut, giving an overall relative risk of 109.6. Areca nut chewing was practiced most commonly in the form of mawa: a mixture containing mainly areca nut (over 90% by weight), some tobacco, and a few drops of lime. Mawa chewers and those who chewed mawa along with other chewing habits showed very high relative risks. The relative risks increased with increase in the frequency as well as the duration of chewing habits. In a bivariate analysis the effect of frequency and duration of chewing appeared to be multiplicative. The present findings confirm areca nut as the most important etiologic factor in oral submucous fibrosi

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1990.tb00804.x

出版商:Blackwell Publishing Ltd    

年代:1990

数据来源: WILEY