摘要:

Regional odontodysplasia is a localized disorder of tissues of dental origin resulting in characteristically bizarre clinical and radiographic appearances. It most commonly affects the maxillary anterior teeth of both the permanent and primary dentitions. The authors present a worldwide bibliography of reported cases and discuss the suggested theories regarding the condition's etiology. Although the majority of cases of regional odontodysplasia must be regarded as idiopathic, various developmental anomalies may produce identical changes in the teeth in one or more quadrants. A number of previously reported cases are also reconsidered with regard to their diagnosis and guidelines are suggested for the treatment of patients affected by regional odontodysplasia.

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1989.tb00394.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

Monoclonal antibodies (Mab) were used to study the expression of cytokeratins and vimentin in various histological types of ameloblastoma and in human fetal tooth germ. The ameloblastoma and the tooth germ epithelia showed characteristics of both simple glandular and stratified squamous epithelial cells. Cytokeratin No. 18 was detected focally in most ameloblastomas studied but not in fetal odontogenic epithelia. Cytokeratins Nos. 8 and 19 were expressed in all epithelial elements of ameloblastomas and tooth germs. Only two tumors showed focally characteristics of keratinizing epithelia also seen in dental lamina but not in the enamel organ. All tumors except the granular cell ameloblastoma showed a variable coexpression of vimentin and cytokeratins in their neoplastic epithelia. A similar coexpression was detected in the stellate reticulum cells of the developing tooth. Ameloblastoma and human tooth germ epithelia share complex pattern of cytokeratin polypeptides together with coexpression of vimentin. The results strongly support the theory that ameloblastomas are of odontogenic origin and not direct derivatives of basal cells of oral epithelium or epidermis.

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1989.tb00395.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

Mast cells have been shown to be present in substantial numbers in both non‐keratinizing and keratinizing odontogenic cysts and could be seen in the connective tissue capsule and the epithelial lining. Within the cyst capsule, mast cells were more prevalent just beneath the epithelium than in deeper areas. This distribution pattern for mast cells is in accord with the histochemical picture for heparin staining in odontogenic cysts. In the non‐keratinizing cysts, there appeared to be some trend towards mast cells being associated with increasing inflammation but not in the odontogenic keratocyst. No evidence could be found for distinct mast cell subpopulations in odontogenic cysts. The presence of mast cells in odontogenic cyst could contribute to their pathogenesis in several w

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1989.tb00396.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

Palates from C3H mice were implanted onto prepared graft beds in histocompatible Fl hybrid mice. Biopsies taken 1, 2, 4, 8, and 16 wk later were prepared to demonstrate Langerhans cells (LC) of C3H and Fl (host) origin. After 1 wk only occasional LC (all of C3H origin) were present. By 2 wk total LC numbers had increased to a level approximately 50% greater than in control (non‐implanted) palate, with most of this increase due to C3H LC proliferation. From 4 through 16 wk total LC numbers were not significantly different from those of control palate. During weeks 2 through 16 the percentages of LC of Fl origin were 31, 70, 39, and 19% respectively. These results indicate an increased proliferation of C3H LC with an initial migration of Fl LC which stops as C3H LC numbers increas

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1989.tb00397.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

Cytokeratin pattern was analyzed in 14 moderately differentiated and 12 well‐differentiated squamous cell carcinomas of buccal mucosa by SDS‐PAGE, immunoblotting and two dimensional electrophoresis. These were compared with patterns of normal buccal mucosa and surrounding areas whenever possible. Normal buccal mucosa expresses keratin No. 4 (59Kd), 5 (58Kd), 13 (54Kd) and 14 (50Kd). Keratin No. 4 (59Kd) and 14 (50Kd) were expressed by 20 of 26 tumors studied, while many of the tumors did not express keratins No. 5 (58Kd) and 13 (54Kd). Keratin No. 1 (67Kd) and 16 (48Kd) were aberrantly expressed by 9 well‐differentiated tumors. Keratin No. 17 (46Kd) and 18 (45Kd) were expressed by 10 and 8 tumors of 14 moderately differentiated tumors. Six tumors which showed involvement of alveolar mucosa, expressed some keratins expressed by its normal counterpart. Their altered expression was consistent with the differentiation pattern as stated earlier. Non‐expression of keratins 5 and 13 seems to be the result of malignant transformation and is seen in the majority of tumors, while appearance of aberrant keratins seems to be related more to the degree of differentiation of th

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1989.tb00398.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

The pattern of keratin expression in hamster cheek pouch epithelium during 15‐wk of DMBA‐induced carcinogenesis was studied. The sequential changes in Cytokeratins of premalignant and malignant tissues and comparative investigation of normal epithelial tissues were examined during a weekly sequential DMBA‐induced chemical carcinogenesis. Keratin polypeptides of normal pouch epithelium appear in a molecular weight range of 43–67 kd and 5–6 proteins can be identified. The disappearance of high molecular weight keratin (61–67 kd) was observed from the 6‐wk DMBA‐treated premalignant group to the 15‐wk DMBA‐treated malignant group. An additional keratin polypeptide was noted initially on the 11th‐wk‐DMBA‐treated group and remained to the 1

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1989.tb00399.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

The purpose of the present investigation was to study the histogenesis of the mucoepidermoid carcinoma of the salivary glands. Eleven cases of mucoepidermoid carcinoma of the minor salivary glands and five of the major glands were extensively studied employing immunohistochemical and fluorescent microscopic techniques. Both the intermediate cells and the duct cells showed a rather similar pattern of reactivity for vimentin, actin and EMA. Also, the intermediate cells and the myoepithelial cells showed a similar reaction pattern for keratin and UGA‐1. The intermediate, myoepithelial and duct cells shared a similar reaction pattern for desmin, myosin, CEA, and S‐100 protein. However, the rest of the tumor markers studied (AFP, PNA and WGA) were found to be non contributary. We also found that the intermediate and to some extent the epidermoid tumor cells showed a positive reaction with Azophloxine GA, which is a selective stain for myoepithelial cells in the normal glands. Based on these findings, the duct cells, the myoepithelial cell in the normal glands and the intermediate cells of the mucoepidermoid carcinoma share certain similar characteristics. The intermediate cells may actually be a mixed population, some having characteristics of the myopithelial cells and others of duct cells. These findings are relevant to the possible role of the intermediate cell in the histogenesis of the mucoepidermoid carcin

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1989.tb00400.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

The Salivary Gland Registry provided 21 cases of epithelial‐myoepithelial duct carcinoma of salivary glands from 1965–1980 which were evaluated retrospectively for clinical follow‐up and cytophotometric data; 81% were localized in the major, 19% in the minor salivary glands. The male: female ratio was 1:1.1, 10 patients (47, 6%) being men and 11 (52,4%) women. The youngest patient was 27, the oldest 91 y old. The mean age was 59.3 y (overall), 57.9 y (women) and 61.0 (men). The clinical course was characterized by lymph node metastases present at initial diagnosis and local recurrences in 23.5%. No patient died of the tumor. In 12 cases, cytochemical assessment of nuclear DNA by means of single cell scanning cytophotometry yielded diploid histograms. According to clinical and cytophotometrical data, epithelial‐myoepithelial duct carcinoma of salivary glands can be regarded as a proper tumor entity of low grade mal

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1989.tb00401.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

The incidence and distribution of keratinocytes expressing the major histocompatability complex antigens HLAJDR, DP and DQ and their relationship to the density of the inflammatory infiltrate was determined in lesions of oral lichen planus and normal mucosa using an immunoalkaline phosphatase technique. Seven of eight biopsies of lichen planus showed evidence of keratinocyte HLA DR expression but the pattern was variable both within and between biopsies. A significant increase in density of lymphocytes was found beneath those areas showing HLA DR expression throughout the prickle cell layer compared with those areas showing patchy or no expression. No evidence for keratinocyte expression of HLA DP or DQ was found. These results suggest that expression of HLA DR by keratinocytes in lichen planus may be induced by the lymphocytic infiltrate perhaps as a result of interferon gamma production. The functional significance of such MHC Class II expression remains unknown.

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1989.tb00402.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY

摘要:

Both labial salivary gland and gingival biopsies were taken from 19 patients with clinical findings suggestive of secondary amyloidosis. Amyloid deposits were present in all salivary gland biopsies (19/19) while amyloid deposits in gingiva were observed only in three cases (16%). No amyloid was found in similar biopsies from 11 control patients. Periductal amyloid involvement was found along the basement membrane in all salivary gland samples; additionally, 16 cases had periacinar infiltration (84%), 13 had perivascular (68%) and 7 (37%) showed interstitial deposits. Amyloid in gingiva was seen along the epithelial basement membrane, as in salivary glands, although in isolated areas and scattered at the top of some dermal papillae and small blood vessels. In secondary amyloidosis it therefore appears that amyloid is deposited along the epithelial basement membrane before perivascular deposition occurs. This study presents a new highly sensitive and reliable method for the diagnosis of secondary amyloidosis, a method which is technically simple, free from complications and well‐accepted by the patient

ISSN:0904-2512    

DOI:10.1111/j.1600-0714.1989.tb00403.x

出版商:Blackwell Publishing Ltd    

年代:1989

数据来源: WILEY