摘要:

Coronal odontoblast-predentine tissue was collected from intact teeth and from teeth with various types of occlusal caries. Lactate (LDH) and malate (MDH) dehydrogenase-like activities in the non-sedimentable (20,200 g), saline-soluble tissue extracts were measured. The calculated LDH/MDH ratio was higher (p < 0.050) in teeth with initial dentine caries (0.81) than in intact teeth (0.67). However, the ratios remained below 1.0 in all types of the tissues analyzed, suggesting a predominantly aerobic metabolism in the odontoblast-predentine region. In the enamel and in the initial dentine caries groups as well as in the group of teeth restored with amalgam, both the LDH and MDH values remained near to the level of intact teeth. The further development of the various lesion was associated with a gradual decrease in the dehydrogenase-like activities. This decrease became significant in recurrent carious lesions. The observation reassured the previously presented concept that a significant depression of several metabolic events occurs in the area of severe injury. Electrophoresis of odontoblast-predentine extracts revealed three anodally migrating LDH isoenzymes. Among these, LDH2 and LDH3 were the most prominent, both with intact and carious samples. This was thought to give further evidence of the aerobic pattern of metabolism suggested to predominate in the area.

ISSN:0008-6568    

DOI:10.1159/000260446

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

The effect of topically applied mutanase (α-1-3-glucan, 3-glucanohydrolase) on plaque formation and caries in rats was studied in two experiments. Compounds known to strongly inhibit dental caries when topically applied served as controls in both experiments. The first experiment investigated whether or not and in what frequency of application this agent was effective in reducing dental caries. In addition, effects on the composition of the plaque flora were examined. Because this first trial resulted in a surprisingly high degree of caries protection, the findings were reinvestigated in a second experiment. In addition to crude mutanase, a partially purified enzyme preparation was included. In both studies, it was demonstrated that mutanase was as effective as fluoride or chlorhexidine in reducing the caries incidence on smooth surfaces and in fissures. However, neither the extent of smooth surface plaque nor its bacterial composition was affected by the enzyme preparation. The only conceivable mode of action is, therefore, thought to be a change in the diffusion properties of dental plaque. Furthermore, the pronounced effect of topically applied mutanase may only be explained by the presence of adequate receptors in the oral cavity allowing long-term retention and release of the enzyme

ISSN:0008-6568    

DOI:10.1159/000260447

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

The cariogenicity of frequent topical applications of water, sucrose, xylitol, sorbitol and sorbose was compared in a 20-day animal study under controlled feeding conditions. Osborne-Mendel rats were orally superinfected with Streptococcus mutans OMZ 176 and Actinomyces viscosus Ny 1 and received 25 daily ‘meals’of 0.4 g of diet 2000a containing 56%sucrose. Two topical applications were administered after each group of 5 programmed meals. The treatments significantly affected the fissure caries incidence. The highest scores were observed in the sucrose and sorbitol group. The number of fissure lesions in the xylitol and sorbose group did not significantly exceed that in the water gr

ISSN:0008-6568    

DOI:10.1159/000260448

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

The concentration of aluminium and strontium was determined (by AAS) in soil (total and exchangeable), drinking water and dental enamel from an area (Zemunik) with low caries prevalence (DMFT 5). A positive correlation between low caries prevalence and a higher concentration of strontium in soil (exchangeable form), drinking water and enamel was found. The distribution of strontium in dental enamel was shown to be fairly uniform. The concentration of aluminium in drinking water and the exchangeable form in soil was higher in the area of Zemunik.

ISSN:0008-6568    

DOI:10.1159/000260449

出版商:S. Karger AG    

年代:1980

数据来源: Karger

ISSN:0008-6568    

DOI:10.1159/000260450

出版商:S. Karger AG    

年代:1980

数据来源: Karger

ISSN:0008-6568    

DOI:10.1159/000260451

出版商:S. Karger AG    

年代:1980

数据来源: Karger