摘要:

Prenatal diagnosis of thalassemia and of the hemoglobinopathies is now accepted as an effective measure to reduce the impact of these diseases in populations where they occur in high frequencies. The procedure has been carried out on more than 5,000 cases over the past decade. Evaluation of the results shows a significant decrease of the yearly number of affected newborns and reflects a considerable gain in economic and medical resources. Methodology has improved over the years so as to make the procedure safer, faster, and less expensive. Among recent advances, gene mapping on trophoblast DNA (as early as the 9th week of pregnancy) represents a major step which will gradually replace conventional procedures (performed during the 18-20th week of pregnancy) in concerned laboratories.

ISSN:0363-0269    

DOI:10.3109/03630268508997023

出版商:Taylor&Francis    

年代:1985

数据来源: Taylor

摘要:

High performance liquid chromatography has been applied to the separation of the globin chains of 16 non-human species which include common mammalian and avian species. The procedure uses a large-pore C. column which has been effectively employed for the separation of human globin chains. in many cases, the gradient for human chains with trifluoroacetic acid-water-acetonitrile was satisfactory or required only moderate modification. The separations were excellent for all except dog hemoglobin. Many results substantiate prior published information about heterogeneity, amino acid composition, etc. of the individual hemoglobins. Additional data on some of these hemoglobins have also been obtained, and some previously unstudied hemoglobins have been examined.

ISSN:0363-0269    

DOI:10.3109/03630268508997024

出版商:Taylor&Francis    

年代:1985

数据来源: Taylor

ISSN:0363-0269    

DOI:10.3109/03630268508997025

出版商:Taylor&Francis    

年代:1985

数据来源: Taylor

ISSN:0363-0269    

DOI:10.3109/03630268508997026

出版商:Taylor&Francis    

年代:1985

数据来源: Taylor

ISSN:0363-0269    

DOI:10.3109/03630268508997027

出版商:Taylor&Francis    

年代:1985

数据来源: Taylor

ISSN:0363-0269    

DOI:10.3109/03630268508997028

出版商:Taylor&Francis    

年代:1985

数据来源: Taylor

ISSN:0363-0269    

DOI:10.3109/03630268508997029

出版商:Taylor&Francis    

年代:1985

数据来源: Taylor

ISSN:0363-0269    

DOI:10.3109/03630268508997030

出版商:Taylor&Francis    

年代:1985

数据来源: Taylor

ISSN:0363-0269    

DOI:10.3109/03630268508997031

出版商:Taylor&Francis    

年代:1985

数据来源: Taylor

ISSN:0363-0269    

DOI:10.3109/03630268508997032

出版商:Taylor&Francis    

年代:1985

数据来源: Taylor