摘要:

The humanγ- chain variants are discussed in relation to their chemical structures and to the importance that their study has had for our present knowledge of the genetics and biosynthesis of hemoglobin chains.

ISSN:0363-0269    

DOI:10.3109/03630267709003416

出版商:Taylor&Francis    

年代:1977

数据来源: Taylor

ISSN:0363-0269    

DOI:10.3109/03630267709003417

出版商:Taylor&Francis    

年代:1977

数据来源: Taylor

摘要:

Molecular hybridization with synthetic radioactive DNA (cDNA) complementary to a globin mRNA sequences shows that, as in most other Southeast Asian populations, the a globin structural genes are deleted in Filipinos affected by theα-thalassemia syndromes. Thus, all 4α-globin structural genes are deleted in homozygousα-thalassemia with hydrops fetalis, 3 and 2 structural genes are deleted in hemoglobin H disease andα-thalassemia-1 respectively.

ISSN:0363-0269    

DOI:10.3109/03630267709003418

出版商:Taylor&Francis    

年代:1977

数据来源: Taylor

摘要:

The DW-cellulose chromatographic procedure which uses glycine-KCN-NaC1 solutions as Developers and a NaCl gradient to elute the hemoglobin zones was found to be useful for the quantitation of Hb F In samples containing Hb A, provided the level of Hb F exceeds 2%. The method has been evaluated through a study of artificial mixtures and of blood samples from patients with various disorders. The data have been compared with results obtained by four other procedures that are used for the quantitation of Hb F.

ISSN:0363-0269    

DOI:10.3109/03630267709003419

出版商:Taylor&Francis    

年代:1977

数据来源: Taylor

摘要:

Three new families providing information on the linkage relationships between the 1 and 3 hemoglobin locl are reported. One of the families contains the first reported indivlduals having Hb S and Hb B2in coupling. Analysis of the information found in the literature is compatible with a recombination frequency of 3% between 3 thalassemia and the 5 structural locus. This highly Improbable frequency might be explained by either diagnostic errors or paternitv problems in the pedigrees containing recombinnnts or by the conceivable possibility that certain thalassemia genes increase the probability for recombination in the chromosomal region containing the non a globin genes.

ISSN:0363-0269    

DOI:10.3109/03630267709003420

出版商:Taylor&Francis    

年代:1977

数据来源: Taylor

摘要:

This paper describes a method which permits the absolute identification of Hb D-Los Angeles Bithout the need for N-terminal or amino acid analysis on peptideβT-13. The procedure involves the formation of the 5-oxo-2-pyrrolidinecarboxylyl derivative of the N-terminal glutamine residue ofβDT-13. This method, together with the use of cadmium ncetate/ninhydrin staining, allows the identification of Hb D-Los Angeles, and other possible mutntions of p121, by peptide mapping.

ISSN:0363-0269    

DOI:10.3109/03630267709003421

出版商:Taylor&Francis    

年代:1977

数据来源: Taylor

摘要:

The effects of 2.3-diphosphoglyceric acid (2,3-DPG), adenosine triphosphate (ATP), inositol tetraphosphate (ITP), inositol pentaphosphate (IPP), and inositol hexaphosphate (IHP) on oxygen affinity of whole“stripped”hemoglobin (WSH), hemcqlobin H (Hb-11; hatching hemoglobin), hemoglobin A (Hb-A), and hemoglobin D (Hb-D) isolated from erythrocytes (RBC) of the 25-day turkey embryo have been studied. The order of the decrease in oxygen affinity induced by these organic phosphates, at molar ratios of phosphate compound to hemoglobin (tetramer) between 2 and 4, is 2,3-DPG

ISSN:0363-0269    

DOI:10.3109/03630267709003422

出版商:Taylor&Francis    

年代:1977

数据来源: Taylor

ISSN:0363-0269    

DOI:10.3109/03630267709003423

出版商:Taylor&Francis    

年代:1977

数据来源: Taylor

摘要:

Human Hemoglobins. H. F. Bunn, B. G. Forget, and ti. M. Ranney W. R. Saunders Company, West Washington Square, Philadelphia, PA, 19105, USA, 1977, 432 pages, $18.00, ISBN 0-7216-2178-3.

ISSN:0363-0269    

DOI:10.3109/03630267709003424

出版商:Taylor&Francis    

年代:1977

数据来源: Taylor

ISSN:0363-0269    

DOI:10.3109/03630267709003425

出版商:Taylor&Francis    

年代:1977

数据来源: Taylor