1. |
Hemoglobin Tottori (α59[E8] Glycine→Valine) a New Unstable Hemoglobin |
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Hemoglobin,
Volume 5,
Issue 5,
1981,
Page 427-439
NakatsujiT.,
MiwaS.,
OhbaY.,
MiyajiT.,
MatsumotoN.,
MatsuokaI.,
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摘要:
A new electrophoretically silent, unstable hemoglobin was discovered in a Japanese family. Isolation of the abnormal chain and chemical analyses demonstrated a previously unreported amino acid substitution,α59[E8] Glycine→Valine. The new variant has been named Hb Tottori.
ISSN:0363-0269
DOI:10.3109/03630268108991818
出版商:Taylor&Francis
年代:1981
数据来源: Taylor
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2. |
The Frequency of theAγTGene in the Presence and Absence of theβsorβCGene in the Black Poplilation of the Southeastern USA |
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Hemoglobin,
Volume 5,
Issue 5,
1981,
Page 441-451
HuismanT. H. J.,
WebberB.,
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摘要:
Quantitative information about the three types ofγchains (AγT, AγI, Cγ) has been obtained for the Hb F from 285 normal Black babies, 172 babies with a Hb S or Hb C heterogeneity, and from 150 babies and older patients with the SS, SC, or CC conditions by means of a high pressure liquid chromatographic micro-procedure. The frequency of theAγTgene in the AA babies was 0.1035, while that in the SS patients was a low 0.0362. This lowAγfrequency in the SS POulation adequately explains the lower percentage (13.2%) of AγTheterozygotes among AS newborn babies as compared to 17.9% among AA Babies. The genotype with the AyT mutant in trans to theβSmutation is presumed to occur about three times more frequently than that in which the AyT mutant is in cis to theβSmutation. A study of family members of one SS patient who has an AyT homozygosity provided data supporting linkage of the AyT andβSanomalies in some Hb S heterozygotes.
ISSN:0363-0269
DOI:10.3109/03630268108991819
出版商:Taylor&Francis
年代:1981
数据来源: Taylor
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3. |
Induction of Heinz Body Formation by Sodium Dithionite |
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Hemoglobin,
Volume 5,
Issue 5,
1981,
Page 453-461
ImanishiHitoshi,
HosokawaKeimei,
ItanoHarvey A.,
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摘要:
Incubation of normal erythrocytes with sodium dithionite resulted in the formation of Heinz bodies, but incubation with sodium metabisulfite did not. Addition of superoxide dismutase to the incubation medium increased the formation of Heinz bodies by sodium dithionite. Addition of catalase to suspensions of erythrocytes in the presence and absence of superoxide dismutase inhibited the formation of Heinz bodies. These findings indicate that hydrogen peroxide, not superoxide, is the active oxidant in Heinz body formation.
ISSN:0363-0269
DOI:10.3109/03630268108991820
出版商:Taylor&Francis
年代:1981
数据来源: Taylor
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4. |
Precipitation of Oxyhemoglobins A and S by Isopropanol |
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Hemoglobin,
Volume 5,
Issue 5,
1981,
Page 463-474
BenderJohn W.,
AdachiKazuhiko,
AsakuraToshio,
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摘要:
The isopropanol precipitation test is widely used for the detection of unstable hemoglobins. A method for accurately and easily determining the amount of hemoglobin precipitated is described. This study demonstrates that changes in incubation time, pH, temperature, and isopropanol and hemoglobin concentrations affect the precipitation of oxy Hb A and oxy Hb S. Hb S shows greater precipitation than Hb A with increasing time, temperature, and isopropanol concentration. Both hemoglobins show equal increases in precipitation, with increases and decreases in pHand decreases in hemoglobin concentration. Comparison of the isopropanol precipitation test with the mechanical shake and heat denaturation tests reveals that the mechanical shake test is the easiest method to study the stability of Hbs A and S. Each of the tests may measure different parameters of stability. The use of all three tests in the evaluation of unstable hemoglobins should be considered.
ISSN:0363-0269
DOI:10.3109/03630268108991821
出版商:Taylor&Francis
年代:1981
数据来源: Taylor
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5. |
Hemoglobin Lille,α2[74(EF3) Asp→Ala]β2 |
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Hemoglobin,
Volume 5,
Issue 5,
1981,
Page 475-479
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ISSN:0363-0269
DOI:10.3109/03630268108991822
出版商:Taylor&Francis
年代:1981
数据来源: Taylor
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6. |
Hemoglobin Duan,α75(EF4) ASP→ALA, a New Variant Found in China |
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Hemoglobin,
Volume 5,
Issue 5,
1981,
Page 481-486
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ISSN:0363-0269
DOI:10.3109/03630268108991823
出版商:Taylor&Francis
年代:1981
数据来源: Taylor
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7. |
A Further Example of Hemoglobin Hikari (β61[E5] Lys→Asn) |
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Hemoglobin,
Volume 5,
Issue 5,
1981,
Page 487-492
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ISSN:0363-0269
DOI:10.3109/03630268108991824
出版商:Taylor&Francis
年代:1981
数据来源: Taylor
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8. |
HB Shepherds Bush (α2β274 (E18) GLY→ASP) in Two Italian Carriers |
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Hemoglobin,
Volume 5,
Issue 5,
1981,
Page 493-496
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PDF (178KB)
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ISSN:0363-0269
DOI:10.3109/03630268108991825
出版商:Taylor&Francis
年代:1981
数据来源: Taylor
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9. |
Hemoglobin Fannin-Lubbockα2β2119 (GH2) GLY→ASP in Spain |
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Hemoglobin,
Volume 5,
Issue 5,
1981,
Page 497-499
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ISSN:0363-0269
DOI:10.3109/03630268108991826
出版商:Taylor&Francis
年代:1981
数据来源: Taylor
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10. |
Binding ofβs,βCandβOArab Globins to the Erythrocyte Membrane |
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Hemoglobin,
Volume 5,
Issue 5,
1981,
Page 501-505
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ISSN:0363-0269
DOI:10.3109/03630268108991827
出版商:Taylor&Francis
年代:1981
数据来源: Taylor
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