摘要:

AbstractThe acquired immunodeficiency syndrome (AIDS) was recognized as a distinct clinical entity in 1981 and was characterized by unexplained opportunistic infections and an aggressive form of Kaposi's sarcoma. High risk groups for contracting AIDS include homosexual men, parenteral drug users, hemophiliacs, recipients of blood and blood products, and heterosexual contacts of such individuals. Immunologic abnormalities associated with AIDS include lymphopenia, functional T‐cell deficits, B‐lymphocyte defects, and various serologic abnormalities. The causative virus has been identified as the human T‐lymphotropic virus/lymphade‐nopathy associated virus (HTLV‐in/LAV). AIDS represents the severe end of the clinical spectrum of infection with HTLV‐in/LAV. Other manifestations are asymptomatic carriage, generalized lymphadenopathy, and a set of non‐specific symptoms, termed the AIDS‐related‐complex (ARC). Although seen predominantly in the United States, AIDS has a world‐wide occurrence. No known therapy for AIDS exists. Research efforts are being directed at antiviral therapy, immunorestoration and the devel

ISSN:8756-0437    

DOI:10.1002/ssu.2980020202

出版商:John Wiley&Sons, Inc.    

年代:1986

数据来源: WILEY

摘要:

AbstractOne hundred and thirty four patients had a second‐look laparotomy in the course of management of cancer of the ovary. Patients were stratified according to four indications: (1) resection of the residual tumor following chemotherapy or radiation therapy, (2) evaluation of the disease with intent to stop chemotherapy and assess signs of recurrence or persistence, (3) restaging, and (4) surgical indication. The first group consisted of 35 patients. In 20 of 35 patients in this group, complete removal of the residual tumor (residual ≦m 2 cm) was possible, and the survival curves indicated that removal of the residual tumor during the second‐look laparotomy improved the survival rate. The second group consisted of 77 patients. No evidence of disease was found in 44 of the 77 patients in this group. Four patients with negative second‐look laparotomy developed recurrences, and three patients died from the disease. The third group consisted of seven patients. In one of seven patients in this group, the stage was modified after second‐look l

ISSN:8756-0437    

DOI:10.1002/ssu.2980020203

出版商:John Wiley&Sons, Inc.    

年代:1986

数据来源: WILEY

摘要:

AbstractAlthough metastatic bladder cancer is difficult to treat effectively, chemotherapy combinations and schedules have emerged recently that can result in long‐lasting complete responses in some patients. Response rates, response durations, and survival patterns of the entire patient population are, however, unsatisfactory. Whereas survival times of these patients following therapy with cisplatin alone or in combination with other drugs are not significantly different, complete response rates are higher and disease‐free survival is longer when combinations are used. Higher dosages are associated with better response rates but also with substantial toxicity. Extensive local pretreatment or prior systemic chemotherapy reduces the likelihood of clinically meaningful disease response. Several adjuvant studies have demonstrated an advantage in length of disease‐free survival for chemotherapy‐treated patients when compared to those who are observed following operation. Metastatic transitional cell bladder cancer is a chemotherapeutically treatable malignancy. Locally advanced disease may be most effectively treated by aggressive surgery followed by cisplatin‐based combination chemotherapy. The highest response rates and longest disease‐free survivals are uniformly associated with aggressive and prolonged multid

ISSN:8756-0437    

DOI:10.1002/ssu.2980020204

出版商:John Wiley&Sons, Inc.    

年代:1986

数据来源: WILEY

摘要:

AbstractThe EAR (Excision, Alcoholization, Replantation) method consists of a proper tumor resection, removal of tumor tissue extracorporally, soaking the residual bone shell in 95% alcohol for half an hour, and replantation in situ, the cavity being filled with bone graft or bone cement. Eighty‐three cases were treated in this manner, of which 95% were followed for 2 years or more, with complete success in cases with IA lesions and no recurrence in two‐thirds of those with IB‐IIB lesions.Experimentally, it is proved that alcohol can kill tumor cells completely without interfering with osteogenesis. The joint cartilage, although degenerated, is replaced by newly formed fibrocartilage, thus preserving joint fun

ISSN:8756-0437    

DOI:10.1002/ssu.2980020205

出版商:John Wiley&Sons, Inc.    

年代:1986

数据来源: WILEY

摘要:

AbstractConstant‐infusion intra‐arterial chemotherapy is associated with a significantly greater tumor response rate and perhaps an improved survival rate. Many intra‐arterial drug delivery systems have been described, the most popular of which is the implanted Infusaid pump. Unfortunately, this is an expensive device that requires considerable experience in its implantation and maintenance. This paper describes a simplified, inexpensive technique, which can comfortably and reliably provide intra‐arterial hepatic chemotherapy to patients treated in most moderate‐size community hospitals. Implantation requires angiography and a minor surgical procedure. Maintenance of the system is easy and inexpensive. While use of the Infusaid pump is preferable, this technique is a reasonable alternative for the following: 1) patients with very poor hepatic function, 2) patients who cannot afford the implanted pump, 3) patients who have concomitant extrahepatic tumor, 4) patients with noncolorectal metastasis to the liver, and 5) patients treated at hospitals that do not have implanted pump cap

ISSN:8756-0437    

DOI:10.1002/ssu.2980020206

出版商:John Wiley&Sons, Inc.    

年代:1986

数据来源: WILEY

摘要:

AbstractFor decades, the role of surgery in the treatment of primary liver cancer (PLC) was important but limited. However, a comparison of pathologically proven PLC during the three periods 1958–1966, 1967–1975, and 1976–1984 revealed that as a result of alpha fetoprotein (AFP) serosurvey, changing concepts in surgical oncology, and introduction of new surgical modalities, the role of surgery has become greater. The increasing proportion of subclinical PLC (0, 7.2, and 21.2%) has favored the increasing series resection rate (16.1, 34.7, and 39.6%) and palliative surgery (13.7, 17.0, and 29.8%). The results indicated that early resection, reoperation for subclinical recurrence, resection of huge PLC in stages, and combination of palliative surgery other than resection might be responsible for the increasing 5‐year survival rate (1.7, 7.1, and 19.5%) in the entire

ISSN:8756-0437    

DOI:10.1002/ssu.2980020207

出版商:John Wiley&Sons, Inc.    

年代:1986

数据来源: WILEY

ISSN:8756-0437    

DOI:10.1002/ssu.2980020201

出版商:John Wiley&Sons, Inc.    

年代:1986

数据来源: WILEY