ISSN:8756-0437    

DOI:10.1002/ssu.2980080402

出版商:John Wiley&Sons, Inc.    

年代:1992

数据来源: WILEY

摘要:

AbstractLower genital tract neoplasia appears associated with certain types of the human papilloma virus. Surgical approaches using lasers and electricity are available to treat the clinical diseases and in turn provide good cosmetic and functional anatomy. The surgical method employed depends upon the anatomical and histological distribution of disease regardless of its site. Of the three areas (cervix, vagina and vulva), cervical intraepithelial neoplasia is the least difficult to cure. Vulvar intraepithelial neoplasia is the most difficult since recurrences can occur at any time and in some patients for many years.

ISSN:8756-0437    

DOI:10.1002/ssu.2980080403

出版商:John Wiley&Sons, Inc.    

年代:1992

数据来源: WILEY

摘要:

AbstractWith proper selection of patients with non‐operative esophageal cancer, palliative therapy with Nd:YAG laser enhances the quality of life by improving the patient's ability to swallow soft or solid food. Also, the use of non‐thermal laser light to initiate the process of photodynamic therapy (PDT) is an additional laser technique that appears effective, not just in palliative treatment, but also in the cure of early esophageal cancer. For PDT, considerable work will be necessary to provide standard techniques in tumor staging, light and drug delivery and in light dosimetry. Ultimately, palliative and curative therapy of esophageal cancer will most likely incorporate multiple modalities, including surgery, radiation, chemotherapy, stents, laser and other thermal modalities, photodynamic therapy, and combinations of these meth

ISSN:8756-0437    

DOI:10.1002/ssu.2980080404

出版商:John Wiley&Sons, Inc.    

年代:1992

数据来源: WILEY

摘要:

AbstractLaser energy can be used for a variety of neoplastic diseases including benign tumors, early stage malignancies, and advanced carcinomas, either with curative intent or for palliation. Nd:YAG laser photocoagulation of 168 colorectal adenomas allowed a complete eradication in 70% of cases, after a mean follow‐up of 22 months. Advanced and obstructing tumors were treated with Nd:YAG laser to recanalize the lumen. In the upper gastrointestinal tract the recanalization of the lumen by means of laser photocoagulation improved the quality of life and survival. In fact, in our series of 308 patients treated, 1‐year survival was 23% in recanalized patients and 7% in nonrecanalized patients.In the lower gastrointestinal tract, 289 cancer patients were treated and an amelioration of symptoms related to the obstruction was obtained in 93%). The current indication for photodynamic therapy is mainly the treatment of flat or ulcerative early stage tumors in the esophagus and stomach of high risk patients. Out of 17 patients treated, 14 were locally cu

ISSN:8756-0437    

DOI:10.1002/ssu.2980080405

出版商:John Wiley&Sons, Inc.    

年代:1992

数据来源: WILEY

摘要:

AbstractThe Nd:YAG laser enables endoscopic destruction of bladder tumors under excellent viewing conditions in a specific and calculable way for induction of homogeneous necroses with simultaneous occlusion of blood and lymphatic vessels. The low local relapse rate, in contrast to that with TUR, is remarkable. By Nd:YAG laser application in combination with or without pelvine lymphadenectomy we were able to reduce the cystectomy rate significantly in recent years.

ISSN:8756-0437    

DOI:10.1002/ssu.2980080406

出版商:John Wiley&Sons, Inc.    

年代:1992

数据来源: WILEY

摘要:

AbstractPhotodynamic therapy (PDT) is an experimental form of cancer therapy which employs photoactivation of a sensitizing chemical by light of a given wavelength via the production of toxic oxygen species. PDT causes local destruction of cancer, and relies on a therapeutic index between normal and malignant tissue since the latter seems to selectively retain the sensitizer. PDT has both direct tumoricidal effects as well as indirect effects on tumor vasculature causing an early hemorrhagic necrosis of tissue. The treatment has been used for the treatment of endobronchial obstruction by primary and metastatic tumors. Most recently, trials are being performed to evaluate this therapy as a surgical adjunct in the treatment of pleural malignancies such as mesothelioma.

ISSN:8756-0437    

DOI:10.1002/ssu.2980080407

出版商:John Wiley&Sons, Inc.    

年代:1992

数据来源: WILEY

摘要:

AbstractDuring the past decade and a half, the photothermal and photochemical effects of several medical lasers have been studied for the clinical treatment of benign and malignant, primary and secondary central nervous system tumors. Increased precision and hemostasis during tumor excision while limiting manipulation and retraction of nervous tissues are possible with the microsurgical carbon dioxide, argon, and frequency doubled neodymium:YAG lasers. Computerized tomography and magnetic resonance imaging‐directed volumetric tumor removal by laser is feasible with computer‐generated visual displays referenced to the patient's anatomy using stereotactic instrumentation. Photodynamic therapy with hematoporphyrin derivative as the photosensitizer and neodymium:YAG laser hyperthermia are currently under evaluation for the treatment of residual and recurrent malignant tumors. Encouraging results have been reported for each of these nonablative forms of laser

ISSN:8756-0437    

DOI:10.1002/ssu.2980080408

出版商:John Wiley&Sons, Inc.    

年代:1992

数据来源: WILEY

摘要:

AbstractThe failure rate of cancer treatment remains unacceptably high, still being a leading cause of mortality in adults and children despite major advances over the past 50 years in the fields of surgery, radiation therapy, and, more recently, chemo and immunotherapy. In the United States, the 5‐year survival rate for all cancers in the population has increaed by only approximately 10% since 1960.Surgical access to some deep tumors of the head and neck and other areas often require extensive dissections with residual functional and cosmetic deformities. Repeated treatment is not possible after maximum dose radiotherapy and chemotherapy is still limited by its systemic toxicity. An attractive solution to these problems would be the development of a new adjunctive method combining the best features of interstitial laser phototherapy for selective tumor destruction via minimally invasive techniques for access and 3D‐magnetic resonance imaging (MRI) as a monitoring system for laser‐tissue interactions. Our experience with this new technique is rev

ISSN:8756-0437    

DOI:10.1002/ssu.2980080409

出版商:John Wiley&Sons, Inc.    

年代:1992

数据来源: WILEY

摘要:

AbstractExperimental studies have shown that once the appropriate laser parameters are defined, interstitial laser hyperthermia (ILH) can produce well‐defined, predictable tissue necrosis in solid viscera which heal safely with little functional or structural sequelae. Preliminary clinical studies have illustrated that ILH is simple to perform, is well tolerated producing radiological and histological evidence of necrosis in liver, pancreatic, and breast cancer. Its future role in most cases will be palliative, controlling local tumour growth. Where the extent of necrosis can be matched accurately to tumour volume, the prospect for cure exists. Further research is necessary before ILH can be regarded as an established treatment and, in particular, its influence on patient survival is worthy of further evaluatio

ISSN:8756-0437    

DOI:10.1002/ssu.2980080410

出版商:John Wiley&Sons, Inc.    

年代:1992

数据来源: WILEY

摘要:

AbstractControlled exposure of photoactive compounds to light prior to their use in biological targets results in the formation of heretofore unknown photoproducts. This process of photoproduct generation, termed preactivation, renders the photoactive compound capable of systemic use without further dependence on light. We have demonstrated that preactivated Merocyanine and preactivated Photofrin‐II possess significant antitumor and antiviral activity against certain tumor cells and viruses, while under identical conditions normal cells and tissues are minimally affected. Thus, the preactivation procedure may represent a promising therapeutic modality for controlling systemic malignancies and viral infection

ISSN:8756-0437    

DOI:10.1002/ssu.2980080411

出版商:John Wiley&Sons, Inc.    

年代:1992

数据来源: WILEY