ISSN:8756-0437    

DOI:10.1002/ssu.2980100202

出版商:John Wiley&Sons, Inc.    

年代:1994

数据来源: WILEY

ISSN:8756-0437    

DOI:10.1002/ssu.2980100203

出版商:John Wiley&Sons, Inc.    

年代:1994

数据来源: WILEY

摘要:

AbstractA transforming gene was cloned from a focus of rat fibroblast cell line Rat 1 transfected with DNA of a gastrocarcinoma cell line. The transforming gene is the activated form of oncogene c‐Ha‐ras, and the lesion was identified as a single nucleotide substitution at codon 12 by sequencing. We further used polymerase chain reaction (PCR)‐restriction analysis to detect the mutations at codon 12 of c‐Ha‐ras. By using this method, 11 cases out of 24 solid tumors and 3 cell lines of gastric cancer were shown to contain mutations, and there was a strong correlation between mutations and metastasis and survival of the patients. The role of the activated c‐Ha‐rasin tumorigenesis of stomach cancer was further proved through the assay in which the malignant phenotypes of the c‐Ha‐ras‐transformed cells were partially inhibited by blocking the c‐Ha‐rasexpression with antisense oligonucleotides or exogenous plasmid expressing antisense RNA.

ISSN:8756-0437    

DOI:10.1002/ssu.2980100204

出版商:John Wiley&Sons, Inc.    

年代:1994

数据来源: WILEY

摘要:

AbstractA clinical trial of radioimmunoguided surgery (RIGS) using 131‐I labeled monoclonal antibody (MAb) 3H11 was performed on 25 cases with gastric cancer in this study. The results showed that the route of the administration of radiolabeled MAb is the key point of successful RIGS for gastric cancer. The RIGS in 19 cases in the group of submucosal injection via endoscope was very satisfying. For the detection of metastatic lymph nodes, the sensitivity rate of RIGS was 99.2% (118/119), the specificity, 97.7% (43/44), and the accuracy 98.8% (161/163). The accuracy rate in detecting tumor infiltration of the gastric wall was 95.9% (94/98), the sensitivity 94.6% (35/37), and the specificity 96.7% (59/61). Thus, the use of RIGS may improve the radical resectability rate and possibly the overall survival rate in patients with gastric cancer. © 1994 Wiley‐Liss,

ISSN:8756-0437    

DOI:10.1002/ssu.2980100205

出版商:John Wiley&Sons, Inc.    

年代:1994

数据来源: WILEY

摘要:

AbstractThe expression of p185erbB2and p21raswas determined immunohisto‐chemically in normal mucosa, intestinal metaplasia, dysplasia and in intestinal and diffuse type carcinoma of the stomach. The positive rates of p185erbB2and p21rasin intestinal type were significantly higher than those of diffuse‐type carcinoma. The results indicate that there are differences not only in clinical and biologic features, but also in molecular abnormalities between the two types of stomach cancer. Positive staining of cell membrane for p185erbB2was observed specifically in intestinal type cancer, but not in the other lesions. Positive expression of p185erbB2on the cell membrane appears to be a useful marker in identification of malignant change of gastric mucosa, as well as a late event of gastrocarcinogenesis. The results of in situ hybridization analysis in cancer tissues were consistent with those obtained by immunohistochemistry and demonstrated amplification oferbB2gene at the mRNA level. No significant difference of p21rasexpression was found among intestinal metaplasia, dysplasia, and intestinal type carcinoma; therefore, it might not be a specific marker of malignancy in gastric mucosa. Expression of p21rasmay be an early event in the development of lesions predisposing to carcinoma. © 1994 Wiley‐Lis

ISSN:8756-0437    

DOI:10.1002/ssu.2980100206

出版商:John Wiley&Sons, Inc.    

年代:1994

数据来源: WILEY

摘要:

AbstractSix hundred seventeen cases of gastric dysplasia were studied morphologically and were grouped histogenetically into adenomatous, cryptal, regenerative, and globoid dysplasias. The characteristics and their relationships with various histological types of gastric carcinoma were analysed as well. Twenty‐four cases of gastric dysplasia showed malignant change, which was most commonly seen in regenerative dysplasia in five high‐incidence areas of gastric dysplasia in China. The causative factors of gastric dysplasia, especially regenerative dysplasia, were analysed in terms of foodstuffs and eating habits of the local inhabitants. © 1994 Wiley‐Lis

ISSN:8756-0437    

DOI:10.1002/ssu.2980100207

出版商:John Wiley&Sons, Inc.    

年代:1994

数据来源: WILEY

摘要:

AbstractSurgery to the extent of R+1[gastric resection plus removal of group 1 lymph nodes (N1) and part of group 2 lymph nodes (N2)] is adequate for cancer confined to the mucosa when the serosa is normal, while operation at the R2 level is adequate for cancer confined to the submucosa (SM) or the muscularis propria (PM) when the serosa is of the reactive type. As the status of serosal involvement advances from normal to reactive, nodular, tendonoid and colour diffused, the lymph node metastatic rate soars and the 5‐year survival rate declines in that order.There were no peritoneally shed cancer cells in cases with normal or reactive serosa over the lesion. Shed cancer cells increased significantly when the serosal involvement exceeded 30 cm2.The 2‐year survival rate of the patients who had serosal involvement increased by 23.1% when peritoneal lavage with 43d̀C distilled water was done. © 1994 Wiley‐Li

ISSN:8756-0437    

DOI:10.1002/ssu.2980100208

出版商:John Wiley&Sons, Inc.    

年代:1994

数据来源: WILEY

摘要:

AbstractA total of 207 patients with advanced upper gastrointestinal tumors were treated with photodynamic therapy (PDT) from 1982 to 1992. This paper reports on the effectiveness and evaluates the follow‐up survey of the results. The patients were aged 29‐91 years, of whom 189 were men and 18 women. Forty‐eight to 72 hr prior to irradiation, 5 mg/kg of HpD was injected intravenously. An argon pumped dye laser was used with an output beam of 630 nm. The entire tumour received an estimated energy dose of 200‐250 J/cm2. The diagnosis of cancer was confirmed by biopsy and histological examination. Of the 207 cases treated, 45 had cancer of the esophagus, 123 had cancer of the cardia, and 39 had cancer of the stomach. Response to PDT was seen in 146 patients (70.5%), with CR in 31 patients who were followed up for 6 months to 10 years. Seven of the latter patients (22.6%) survived more than 5 years and are still under close follow‐up. © 1994 Wiley

ISSN:8756-0437    

DOI:10.1002/ssu.2980100209

出版商:John Wiley&Sons, Inc.    

年代:1994

数据来源: WILEY

摘要:

AbstractIn 136 patients (115 males and 21 females) with advanced gastric cancer confirmed histologically, a regimen of high‐dose mitomycin C plus tegafur or UFT was administered. Dosage of agents used and schedules were as follows: MMC 20 mg i.v. once a week up to a total of 60 mg, followed either by tegafur 600 mg/day p.o. to a total dosage of 20‐40 g, or by UFT 450 mg/day p.o., to a total dosage of 30 g. Patients' ages ranged from 24 to 75 years. Of this series, 70 patients were deemed inoperable, 21 patients underwent nonradical surgical operation, and the other 45 patients had postoperative recurrent disease. Of the 136 patients, 78 achieved complete tumour remission (CR) (21/136) and partial remission (PR) (57/136), yielding a response rate of 57.4%. The median duration of remission and survival was 5.2 (range 2‐16 + ) and 10.1 (range 3‐48 +) months. The main side effects were leukopenia and thrombocytopenia. None of these patients had liver or kidney function damage. © 1994 Wiley

ISSN:8756-0437    

DOI:10.1002/ssu.2980100210

出版商:John Wiley&Sons, Inc.    

年代:1994

数据来源: WILEY

摘要:

AbstractPeritoneal dissemination is the major pattern of recurrence in patients with gastric cancer. Among the 1,337 patients with gastric cancer who underwent a curative resection, a multivariate analysis showed that the independent risk factors for the occurrence of peritoneal dissemination were an undifferentiated tissue type and serosal invasion. We focus our attention on 477 patients with undifferentiated type tumor, in which the postoperative prognosis and the pattern of recurrence after curative resection were evaluated with regard to the depth of the cancerous invasion in the gastric wall. Patients with tumors limiting to the subserosal layer had a satisfactory post‐operative course, with five‐year survival rates of 98.5%, 97.4%, and 82.5% in patients with tumors limiting to the submucosal layer, the muscularis propria and subserosal layer, respectively. In 179 patients with tumors invading to the subserosal layer, however, the five year survival rate was only 48.2%. Seventy‐one died of peritoneal dissemination, while 24 and 15 were due to hematogenous and local recurrences, respectively. Only 50 (27.9%) survived over 5 years without any recurrence. © 1994 Wiley‐L

ISSN:8756-0437    

DOI:10.1002/ssu.2980100211

出版商:John Wiley&Sons, Inc.    

年代:1994

数据来源: WILEY