ISSN:0275-665X    

出版商:OVID    

年代:1990

数据来源: OVID

摘要:

With increasing numbers of women delaying child-bearing past the age of 30, it becomes important to determine if such shifts in childbearing patterns are reflected in higher maternal and neonatal perinatal morbidity. To assess this issue, the authors evaluated 3917 consecutive primiparous women, 20 years or older, delivering a singleton infant for the period 1985–1987. Data were derived from computerized data-adapted forms. Information gathered included rates of low-birth-weight, pre-term and small-for-gestational-age deliveries, fetal mortality in fetuses weighing 500 g or more, antepartum and intrapartum complications, cesarean delivery rates, frequency of low Apgar scores, need for NICU admission, and the relationship between age and such covariates as race, education, smoking and chronic medical conditions (hypertension, diabetes).

ISSN:0275-665X    

出版商:OVID    

年代:1990

数据来源: OVID

ISSN:0275-665X    

出版商:OVID    

年代:1990

数据来源: OVID

摘要:

Fetal or neonatal asphyxia may be associated with multiple organ failure in the neonatal period resulting from such dysfunctions as renal failure, meconium aspiration, shock, necrotizing enterocolitis, intra-cranial hemorrhage and acute encephalopathy. The authors sought to define a set of easily applied criteria for assessment of perinatal asphyxia which might also predict morbidity within the neonatal period.

ISSN:0275-665X    

出版商:OVID    

年代:1990

数据来源: OVID

摘要:

Studies of congenital abnormalities in mothers treated for epilepsy have implicated trimethadione, phenytoin. valproic acid and carbamazepine as potential teratogens. The teratogenicity of drugs such as phenytoin is suspected to be mediated not by the parent compound but by toxic intermediate metabolites. Oxidative intermediates (epoxides) eliminated in a reaction catalyzed by epoxide hydrolase are believed to be the primary teratogenic agents of phenytoin and also carbamazepine. Thus there might be a relationship between epoxide hydrolase activity in amniocytes and the risk of anomalies associated with fetal hydantoin syndrome.

ISSN:0275-665X    

出版商:OVID    

年代:1990

数据来源: OVID

摘要:

As a result of increasing interest in organ transplantation from infants with anencephaly, the Medical Task Force on Anencephaly was formed to report on medical issues relating to the anomaly.

ISSN:0275-665X    

出版商:OVID    

年代:1990

数据来源: OVID

摘要:

Doppler studies of flow velocity waveforms may be performed to assess both the fetal umbilical and maternal uterine circulations. The current study was designed to record flow velocities in these circulations in women with severe hypertensive disease of pregnancy and to relate the findings to severity of maternal disease and fetal outcome.

ISSN:0275-665X    

出版商:OVID    

年代:1990

数据来源: OVID

摘要:

Although hypertension is common in pregnancy, the question of which women should be given antihypertensive drugs and at what level of blood pressure has not been resolved. Drug therapy is required for diastolic pressures exceeding 105–110 mmHg, but the benefits of drugs at lower pressures in preventing miscarriage, perinatal death or IUGR remain to be established.

ISSN:0275-665X    

出版商:OVID    

年代:1990

数据来源: OVID

摘要:

Although magnesium sulfate is the most widely employed drug for the prevention and management of convulsions in eclampsia, studies have suggested that phenytoin may be more specific. To assess this issue, the author studied 22 patients with eclampsia who had received only a single dose of 1–2 mg of clonazepam following a first convulsion. In the hospital, patients were randomly assigned to receive a loading dose of 4 g of MgSO4followed by an infusion of 1–2 g/h, or a loading dose of 500 mg of phenytoin, followed by two 500 mg doses given over 4 hours at an interval of 12 hours. Periodic serum levels of Mg and phenytoin were determined 30 minutes after the loading dose and then every 6 hours. Blood pressures in excess of 115 mmHg diastolic were controlled with dihydralazine infusion. Side effects for each drug were recorded and pregnancy was terminated as soon as convulsions and hypertension were controlled.

ISSN:0275-665X    

出版商:OVID    

年代:1990

数据来源: OVID

摘要:

A 36-year-old woman required excision of laryngeal granulomata in her 34th week of gestation. She had airway obstruction due to the granulomata and subglottic stenosis which resulted from emergent; intubation after a drug overdose 6 weeks earlier. Fetal heart rate pattern was normal. After IV administration of midazolam 2 mg, fentanyl 100 μg. thiamylal 250 mg, and slow infusion of succinylcholine, decreased beat-to-beat variability was noted within 3 min. Inhaled anesthetics included 50% N2O-O2-0.5% enflurane. Twenty minutes later, there was complete absence of beat-to-beat variability and a downward shift of the baseline from 150 beats/min to 130. Maternal BP decreased progressively from 152 94 to 110/60 mmHg. After the patient awakened, fetal heart rate pattern and baseline returned to normal A healthy infant was delivered vaginally 6 weeks later Since no uterine contractions occurred during the period of anesthetization, it may be assumed that these fetal heart rate changes resulted from interference with functioning of the fetal central nervous system by large doses of anesthetics traversing toe placenta. Thus, loss of beat-to-beat variability associated with general anesthesia is probably normal for the anesthetized fetus.

ISSN:0275-665X    

出版商:OVID    

年代:1990

数据来源: OVID