摘要:

The combination of sulphadiazine 225 mg (SD) and trimethoprim 75 mg (TMP) was compared with the combination of sulphamethoxazole 400 mg (SM) and trimethoprim 80 mg (TMP) in the treatment of acute respiratory tract infection using a randomized double-blind clinical trial. The dose of both preparations was two tablets twice daily for 7–14 days. The patients were 200 conscripts hospitalized for an acute respiratory infection warranting antibacterial treatment. The most frequent diagnoses were pneumonia, bronchitis and tonsillitis. The combination SD/TMP was statistically significantly (p < 0.001) superior to the combination SM/TMP regarding overall efficacy of all indications. Especially pneumonia and bronchitis responded more favourably to SD/TMP than to SM/TMP. The duration of fever was also shorter (p < 0.001) with SD/TMP than with SM/TMP. The occurrence of side effects was 2% in both treatment group

ISSN:0009-3157    

DOI:10.1159/000237920

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

The slow integration of antituberculosis programmes into general health service activities is the most important problem encountered. Short course regimes with high cost drugs require the supervision which, for the time being, is difficult to realize on a large scale except, perhaps, in big cities. Though pilot studies of short course regimes are wellcomed, for the immediate use in both the capitals and the rural areas mainly self-administered low-cost systems may be considered for the chemotherapy of tuberculosis, with basic division of patients into groups of previously untreated and previously treated persons (which would affect the drug combination used), and smear (and culture?) positive or negative persons (which might affect the duration of therapy administered). For the latter, it is of considerable importance to continue improving the network of bacteriological laboratories.

ISSN:0009-3157    

DOI:10.1159/000237921

出版商:S. Karger AG    

年代:1980

数据来源: Karger