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11. |
Bacteriostatic and Bactericidal Activity of Two Trimethoprim-Sulfonamide Combinations |
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Chemotherapy,
Volume 22,
Issue 3-4,
1976,
Page 262-273
E. Böhni,
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PDF (2663KB)
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摘要:
Sulfamoxole (SDMO) has the same half-life of elimination from human plasma as sulfamethoxazole. Its antibacterial properties, however, are often inferior to those of co-trimoxazole. Its less pronounced antibacterial effect, especially against gram-negative pathogens, also becomes evident in the combination with trimethoprim (TM). The inhibition zones are often smaller around discs containing the same amount of the components SDMO/TM as those with co-trimoxazole and the inhibitory concentrations needed are frequently 2–4 times higher, especially against gram-negative bacteria, such as Escherichia coli and Proteus vulgaris. Accordingly, the curative doses 50% of the new combination are 2–3 times higher than those of co-trimoxazole in experimental infections with E. coli and P. vulgaris in mice. The bactericidal action in human urine, collected after a course of treatment with the combination SDMO/TM in the planned lower dosage, is not only often retarded, but also frequently incomplete in comparison with that in urine after co-trimoxazole in standard dosage. Clinically, this might lead to increased development of resistance or to an increase of recurrent infecti
ISSN:0009-3157
DOI:10.1159/000221933
出版商:S. Karger AG
年代:1976
数据来源: Karger
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12. |
Recent Antiviral Chemotherapy Publications |
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Chemotherapy,
Volume 22,
Issue 3-4,
1976,
Page 274-276
Preview
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PDF (901KB)
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ISSN:0009-3157
DOI:10.1159/000221934
出版商:S. Karger AG
年代:1976
数据来源: Karger
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