摘要:

A double-blind study on 72 adult patients affected by typhoid fever was done utilizing a new sulfa-trimethoprim combination (trimethoprim-sulfamethopyra-zine) versus the well-known combination trimethoprim-sulfamethoxazole. The dosage used for the new drug was 2 capsules (250 mg trimethoprim + 200 mg sulfamethopyra-zine per capsule) the 1st day and 1 capsule for the following 14 days or 2 capsules (trimethoprim 80 mg + sulfamethoxazole 400 mg per capsule) twice daily for 15 days. Both drugs proved to be very effective according to the parameters considered. No complications (intestinal bleeding, perforation, etc.) occurred in any of the patients, and untoward effects were not observed. It is therefore our opinion that treatment of typhoid fever with a sulfa-trimethoprim combination is both effective and safe.

ISSN:0009-3157    

DOI:10.1159/000238316

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

In the course of 1 year, 180 patients undergoing elective surgery for confirmed cholelithiasis were included in a prospective randomized study in which they either received 2 g of preoperatively applied ceftriaxon intravenously at the beginning of anesthesia or, as an alternative, no antibiotic at all. Infectious wound-healing disturbances occured postoperatively in 11 % in the control group and in no case in the pro-phylaxis.group. The difference is statistically significant.

ISSN:0009-3157    

DOI:10.1159/000238317

出版商:S. Karger AG    

年代:1985

数据来源: Karger

ISSN:0009-3157    

DOI:10.1159/000238318

出版商:S. Karger AG    

年代:1985

数据来源: Karger