摘要:

The new fluoroquinolones have many attributes and relatively few drawbacks. As a result, they have been rapidly adopted for the treatment of serious bacterial infections. The currently available fluoroquinolones are particularly effective for the treatment of urinary tract infections, bacterial diarrhea, enteric fever, gonorrhea, chancroid, skin and soft tissue infections, acute and chronic gram-negative osteomyelitis, gram-negative pneumonias, serious infections due to a variety of gram-negative bacilli, and in the eradication of the meningococcal carrier state. As we learn more about the properties of these compounds, the number and variety of infections for which they are useful continues to expand.

ISSN:0009-3157    

DOI:10.1159/000239492

出版商:S. Karger AG    

年代:1996

数据来源: Karger

摘要:

Two sulfated xylogalactans (F1 and F7), isolated from the red seaweed Nothogenia fastigiata, achieved a dose-dependent inhibition of the replication of herpes simplex virus type 1 (HSV-1) in Vero cells, with 50% effective doses in the range of 15.0–32.6 μg/ml, and without affecting cell viability at concentrations up to 200 μg/ml. The presence of sulfate groups in the molecule was essential for the antiviral properties of these polysaccharides. F7 afforded significant inhibition in HSV-1 yield if added to the cell cultures simultaneously with virus inoculum, but had no effect when it was added after 1 h of infection. Analysis of the early events of the viral replicative cycle showed that the anti-HSV effect of F7 was due to a specific inhibition of virus attachment to the host cell whereas virus internalization was not impaired.

ISSN:0009-3157    

DOI:10.1159/000239422

出版商:S. Karger AG    

年代:1996

数据来源: Karger

ISSN:0009-3157    

DOI:10.1159/000239493

出版商:S. Karger AG    

年代:1996

数据来源: Karger

摘要:

CMF and radiation treatment alter the erythrocyte membrane architecture in breast cancer patients by inducing free radical formation in the system. The increased free radicals hydrolyze the unsaturated fatty acyl chains of membrane phospholipids and thus alter the membrane lipid profile. To assess the erythrocyte membrane damage caused by CMF chemotherapy and radiation treatment among breast cancer patients and to find a way which can protect them from the observed toxic manifestations form the basis of this study.

ISSN:0009-3157    

DOI:10.1159/000239423

出版商:S. Karger AG    

年代:1996

数据来源: Karger

摘要:

The capacity of phagocytes to concentrate macrolide antibiotics was suggested by previous reports. In this study, we evaluated the capacity of Haemophilus influenzae type b culture supernatants (HICS) to induce polymorphonuclear leukocyte (PMNL) migration and macrolide antibiotic delivery. Using a Boyden multiwell chamber and a chemotaxis assay under agarose combined with a bioassay to measure antibiotic levels in agar, we demonstrated the chemotactic activity of HICS. Preincubation of PMNL with either erythromycin or azithromycin did not affect PMNL chemotaxis. By the agar diffusion test, we established that HICS increased the release of antibiotic from PMNL when compared with spontaneous release. Furthermore, we determined that the antibiotics remain bioactive after release. These results suggest that HICS may have a modulatory effect on transport and delivery of macrolide antibiotics by PMNL at the infection site.

ISSN:0009-3157    

DOI:10.1159/000239424

出版商:S. Karger AG    

年代:1996

数据来源: Karger

摘要:

One hundred symptomatic women with clinical bacterial vaginosis (BV) were enrolled in this study. The bacteriological epidemiology of BV and efficacy of oral or vaginal administration of antimicrobial agents for treatment of BV were investigated. The epidemiology of BV was investigated before antimicrobial therapy. Fifty patients were treated with oral administration of metronidazole (MTN), 500 mg twice a day, and 50 patients with 2% clindamycin (CLDM) phosphate in a vaginal cream, 5 g once a day for 7 days. The major organisms occurring were Streptococcus agalactiae, Escherichia coli, Gardnerella vaginalis, Peptostreptococcus species, Bacteroides species, Prevotella species, and Mobiluncus species and opportunistic pathogens such as Staphylococcus epidermidis and Enterococcus faecalis. The therapeutic efficacy of CLDM cream on BV appeared to be preferable to oral MTN from clinical and bacteriological aspects. The clinical and bacteriological effectiveness of MTN and CLDM in the treatment of BV suggests that anaerobes might play a major role in causing the clinical symptoms in patients with BV.

ISSN:0009-3157    

DOI:10.1159/000239425

出版商:S. Karger AG    

年代:1996

数据来源: Karger

ISSN:0009-3157    

DOI:10.1159/000239486

出版商:S. Karger AG    

年代:1996

数据来源: Karger