K. Galova,
S. Sufliarska,
Z. Kukovac,
A. Danisovicova,
I. Hrachova,
S. Grausova,
I. Marinova,
S. Krizan,
K. Stopkova,
A. Stahorska,
K. Durcanska,
J. Raskova,
I. Krupova,
V. Krčméry, Jr.,
In a randomized trial, we compared the efficacy and toxicity of azithromycin and ceftibuten once daily in the initial (empiric) therapy of proven or suspected community-acquired respiratory tract infections (CARTI) in 163 pediatric patients: 95.5% of those treated with azithromycin and 83.6% of those treated with ceftibuten were cured or improved. Streptococcus pneumoniae was more frequently eradicated in the azithromycin than in the ceftibuten group, whereas gram-negative bacilli were more susceptible to ceftibuten. Elimination rates for Staphylococcus aureus and Haemophilus influenzae were similar; adverse reactions did not differ in both arms. Thus, azithromycin was more effective but equally safe than ceftibuten in the initial therapy of pediatric CARTI.
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