|
21. |
Cef operazone Compared with Chloramphenicol in the Treatment of Typhoid Fever |
|
Chemotherapy,
Volume 34,
Issue 1,
1988,
Page 71-76
Giuseppe Morelli,
Modestino Guerriero,
Pasquale Cristiano,
Patrizia Galderisi,
Attilio Postiglione,
Franco Paradisi,
Preview
|
PDF (1999KB)
|
|
摘要:
The authors have conducted an open randomized study to compare the clinical efficacy and safety of cefoperazone with those of chloramphenicol in the treatment of typhoid fever. They studied 56 subjects (28 in each group), 36 males and 20 females, whose average age was 25.9 years. The diagnosis of typhoid fever was made when one of the at least three blood cultures performed was positive for Salmonella typhi and in the presence of a ‘toxic’-like symptomatology and hyperpyrexia (39 °C). Moreover, several stool cultures were done and the signs and symptoms characteristic of the pathology in progress were monitored. Furthermore, the MICs of cefoperazone and chloramphenicol were determined for all the strains of S. typhi isolated in both groups. Cefoperazone was given at the mean dose of 2 g i.v. every 8 h, and chloramphenicol at the dose of 500 mg by oral route every 6 h. The results obtained were assessed statistically (Friedman’s test and Fischer’s test). The authors conclude that cefoperazone is as active as chloramphenicol, and the importance of this result should not be undere
ISSN:0009-3157
DOI:10.1159/000238550
出版商:S. Karger AG
年代:1988
数据来源: Karger
|
22. |
Contents, Supplement 1, 1988 |
|
Chemotherapy,
Volume 34,
Issue 1,
1988,
Page -
Preview
|
PDF (405KB)
|
|
ISSN:0009-3157
DOI:10.1159/000238641
出版商:S. Karger AG
年代:1988
数据来源: Karger
|
|