摘要:

Polyinosinic-polycytidylic acid (poly I:C) was shown to markedly inhibit the incidence and growth rate of Moloney sarcoma virus-induced tumor in BALB/c mice. The therapeutic effect observed with poly I:C alone was abrogated by the addition of DEAE-dx (diethylaminoethyl-dextran) to the poly I:C solution. Serum interferon titers were depressed 50% during the first 48 h of treatment with poly I:C plus DEAE-dx relative to those obtained with poly I:C alone. DEAE-dx stimulated the growth of Moloney sarcoma virus-induced tumors. Poly I:C on a schedule known to be tumor inhibitory failed to potentiate transplantation resistance to a specific tumor-associated transplantation antigen.

ISSN:0009-3157    

DOI:10.1159/000220738

出版商:S. Karger AG    

年代:1971

数据来源: Karger

摘要:

1-β-d-Arabinofuranosylcytosine (ara-C; cytosine arabinoside) administered orally to hamsters bearing cheek pouch grafts of the allogeneic A. Mel. No. 3 melanoma resulted in greater tumor growth inhibition than a relatively equitoxic parenteral schedule of this drug at 20–25% of the oral dose. Clinical trials with a newly developed enteric ara-C tablet, particularly in solid neoplasms, are recommend

ISSN:0009-3157    

DOI:10.1159/000220739

出版商:S. Karger AG    

年代:1971

数据来源: Karger

摘要:

The efficacy and distribution of soluble and insoluble tetracyclines were studied in rats with experimental pyelonephritis due to E. coli. Insoluble oxytetracycline (IOT) was noted to persist in normal kidneys in concentration sufficient to inhibit bacterial growth for as long as 96 h after its injection. Similarly, this preparation significantly prevented the development of pyelonephritis in the rat when administered as long as 96 h prior to bacterial inoculation. Fine crystals of insoluble tetracycline (ITC) were then prepared by alkalinization of a solution of commercially available soluble tetracycline (TC). A single injection of ITC was markedly superior to a single injection of TC in treatment of experimental pyelonephritis in rats, and equivalent to a 6-day course of the latter. Labelled (7–3H) soluble and insoluble tetracyclines were then prepared and their concentrations after i. m. and i. v. injection compared by liquid scintillation counting of selected tissues of normal and pyelonephritic rats (i. e. normal kidney, pyelonephritic lesions, plasma, fat, lung, liver, heart, and spleen). Although TC concentrations were higher from 4 to 12 h after drug injection, at 24 h kidney and plasma concentrations of TC and ITC were equivalent, and by 48 and 96 h the ITC concentrations in the plasma and kidney were significantly greater. Both compounds displayed higher levels in the kidney than in other tissues, with the exception of the site of i. m. injection, or the lung after i. v. injection, where high concentrations of ITC suggested that the insoluble form of the drug formed a depot. In contrast to Castenada’s original suggestion that the insoluble antibiotic was more effective because of phagocytosis of particles of the antibiotic which were then brought to the site of infection, the current data suggest that this is due to depot formation followed by preferential concentration in the kidney, as compared to other tissues. These data indicate that mere changes in the physical property of tetracyclines thus can alter their effectiveness in experimental pyelonephri

ISSN:0009-3157    

DOI:10.1159/000220740

出版商:S. Karger AG    

年代:1971

数据来源: Karger

摘要:

A clinical trial with doxycycline (α-6-deoxy oxytetracycline) was carried out in 28 cases of diabetes mellitus suffering from various pyogenic infections. The clinical response was good in 5 (17.8%), satisfactory in 21 (75.1%) and poor in 2 (7.1%) cases. A good correlation was found in 70% between sensitivity of organisms in vitro and clinical response. The drug was fairly well tolerated by all patients and no side-effect was noticed except mild diarrhoea in 2 cases. This clinical trial suggests that doxycycline is an effective, nontoxic, broad spectrum antibiotic easily administrable in low, single daily dosage schedule

ISSN:0009-3157    

DOI:10.1159/000220741

出版商:S. Karger AG    

年代:1971

数据来源: Karger

摘要:

Uncomplicated acute gonorrhea in 200 cases, 100 of each sex, was treated with a single oral dose of 900 mg rifampicin. The failure rate was 12.5%. The treatment was compared with 1.0 MU of benzyl penicillin and 1.5 MU of procaine penicillin in a single intramuscular injection given to 200 other cases of acute uncomplicated gonorrhea, 100 of each sex. The failure rate was 3.5%. The difference in failure rate between the two treatments is significant. Remarkably quickly after one dose of oral rifampicin in 11 out of 25 cases a high degree of rifampicin resistance developed in the gonococcal strains. Thus for epidemiological reasons the use of rifampicin in the treatment of gonorrhea could quickly lead to the spread of rifampicin-resistant gonococcal strains in the community, and rifampicin must be advised against in gonorrheal therapy, at least as a first hand choice in patients with a penicillin allergy.

ISSN:0009-3157    

DOI:10.1159/000220742

出版商:S. Karger AG    

年代:1971

数据来源: Karger

摘要:

Niridazole (Ambilhar) was used in the treatment of 20 patients with typhoid fever. The drug was effective in 11 patients. They became afebrile within 5.5 ± 1.5 days. Patients who did not respond were then treated with chloramphenicol and became afebrile within 4.4 ± 10 days. One patient developed a severe drug rash while minor side effects, e. g. headache, nausea, vomiting and aches and pains all over the body, were observed in 4 other patients. The therapy of typhoid fever with niridazole is inferior as compared to chloramphenicol. In vitro niridazole sensitivity tests were carried out in 40 strains of S. typhi and 10 of S. paratyphi which also included the strains isolated in this study. By both disc-diffusion and tube-dilution methods, niridazole was sensitive in concentrations of 20 μg/disc or 20 μg

ISSN:0009-3157    

DOI:10.1159/000220743

出版商:S. Karger AG    

年代:1971

数据来源: Karger

摘要:

Nine patients with acute non-complicated brucellosis were treated with Bactrim. The results are discussed.

ISSN:0009-3157    

DOI:10.1159/000220744

出版商:S. Karger AG    

年代:1971

数据来源: Karger

ISSN:0009-3157    

DOI:10.1159/000220745

出版商:S. Karger AG    

年代:1971

数据来源: Karger

ISSN:0009-3157    

DOI:10.1159/000220746

出版商:S. Karger AG    

年代:1971

数据来源: Karger

ISSN:0009-3157    

DOI:10.1159/000220747

出版商:S. Karger AG    

年代:1971

数据来源: Karger