摘要:

The serum levels and urinary excretion of doxycycline, a new tetracycline analogue, were studied in 10 patients with normal and 10 patients with severely impaired renal function. No statistically significant difference was noted between serum levels in two groups, but urinary excretion of the drug was significantly diminished in patients with impaired renal function. The urinary levels in the latter group, however, still surpassed the minimum inhibitory concentration of most urinary pathogens. The drug did not produce azotaemia and showed no other toxic effects.

ISSN:0009-3157    

DOI:10.1159/000221802

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

50 newly prepared pyrimidine derivatives and trimethinium derivatives were tested for the inhibitory activity of vaccinia virus, Newcastle disease virus (NDV) and western equine encephalomyelitis (WEE) virus multiplication using the agar-diffusion plaque-inhibition test. Most of pyrimidine derivatives exerted an inhibitory effect on vaccinia virus. The highest selective effect was found with 2-amino-5-dimethylaminomethyleneaminopyrimidine (derivative No. 35). Much lower inhibitory effect was observed with several derivatives in the WEE virus inhibition. Trimethinium derivatives were not effective in the virus inhibition.

ISSN:0009-3157    

DOI:10.1159/000221803

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

In vitro and in vivo experiments were performed with tri-tetracyclines prepared by mere dissolution of the tetracyclines in an aqueous solution of a recommended complexing agent, or using a preconstituted ready-for-use injection. Values of tri-tetracyclines of low minimal inhibitory concentration (MIC) were recorded. High antibiotic levels were found in the sera and in the tissues, especially in the lung after administration of tri-methacycline and in the kidneys after all tri-tetracyclines examined – indicating excretion via the kidneys. These facts correspond to enhanced water solubility without marked loss of lipid solubilit

ISSN:0009-3157    

DOI:10.1159/000221804

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

Subconjunctival injection of d-thymidine (0.4 ml, 4-percent solution) does not inhibit the regeneration of mechanically damaged rabbit cornea. However, this treatment produces a significant virostatic effect against herpes keratitis in rabbit. Injected intraperitoneally to herpes keratitis-infected syrien hamsters at 400 mg/kg/day, d-thymidine also exhibits significant protection against mortality rate of the animals.

ISSN:0009-3157    

DOI:10.1159/000221805

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

Controlled clinical trials dealing with the first antimycobacterial treatment, published between 1948 and 1971, have been methodologically compared. Three comparable groups have been formed (US-Japan trials, BMRC and IUAT trials with rifampicin in Europe). The significance of individual drugs was calculated by comparison of effects of drug combinations with corresponding monotherapy regimens. The dominance of isoniazid and rifampicin in reduction of mycobacterial population was proved; PAS, thiacetazone and cycloserine mainly prevent the resistance development. Ethambutol, streptomycin and ethionamide form an intermediate group.

ISSN:0009-3157    

DOI:10.1159/000221806

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

Cephacetrile (the sodium salt of 7-cyanoacetamido cephalosporanic acid) was used to treat 21 cases of urinary tract infections in patients from a general urological ward. The patients were followed up at 6 weeks after completing the course of antibiotic and 75% had a bacteriological cure. Serum and urinary levels of cephacetrile were measured and toxicological data were collected on all patients. No adverse effects attributable to the drug were noted.

ISSN:0009-3157    

DOI:10.1159/000221807

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

A controlled clinical trial was carried out in which three drug regimens, rifampicin plus isoniazid, rifampicin plus PAS, and isoniazid plus PAS, administered for 6 months, were compared in patients with newly diagnosed pulmonary tuberculosis. The drugs were given in the following doses: rifampicin, 450 mg up to 60 kg and 600 mg over 60 kg body weight in one dose; isoniazid, 5 mg/kg in one dose; PAS, 10 g up to 60 kg and 12 g over 60 kg body weight, divided in two doses. Bacteriological results showed that all the treatment regimens had a similar efficacy. In the groups of patients who were administered rifampicin, faster disappearance of tubercle bacilli from sputum was observed. The roentgenographic changes were comparable in all groups. According to the results obtained, rifampicin is a drug whose effectiveness and tolerability are comparable with those of isoniazid.

ISSN:0009-3157    

DOI:10.1159/000221808

出版商:S. Karger AG    

年代:1974

数据来源: Karger