摘要:

Quantitative determinations of the sensitivity of 322 Neisseria gonorrhoeae strains to sulphamethoxazole (Su), trimethoprim (Tr) and a combination of Su and Tr in a ratio of 5:1 are described. Data are also given on the potentiation of Su by Tr. It was striking that the Su-sensitive N. gonorrhoeae strains showed no potentiation of Su by Tr when a Su/Tr ratio of 5:1 is used. The sensitivity to combinations of Su and Tr in various ratios was determined for seven N. gonorrhoeae strains with known sensitivity to Su and Tr. On the basis of these data, the rules according to which Su is potentiated by Tr could be formulated.

ISSN:0009-3157    

DOI:10.1159/000221973

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

During the recent epidemic of meningitis in Brazil, 1974, bacteriological and antibiotic sensitivity investigations were performed on 302 strains of Neisseria meningitidis, isolated from meningitis patients from the São Paulo and Rio de Janeiro districts in the first half of 1974. The experiments have shown that 58% of the strains belong to the serological type A, 25% belong to type C and the remaining 17% to a group designated ‘untypable’ in that they did not react with the diagnostic antisera A, B, C, and D. Antibiotic sensitivity tests in vitro have made evident that, independently of the serological type, 89.8% of the 302 strains were inhibited by 10 μg/ml of a long-acting sulfonamide (sulfamethoxypyrazine, SMP), that is, by levels easily reached in the CSF during a normal prophylactic or therapeutic trea

ISSN:0009-3157    

DOI:10.1159/000221974

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

The effect of 12 derivatives of N-phenyl-N′-aryl- or alkylthiourea, inhibitors of human enteroviruses and foot-and-mouth disease virus, on reproduction of some rhinoviruses (H-17, B-632) in HeLa Bristol cells was studied. As screening methods both the multicycle growth test in roller tube cultures and two variants of plaque inhibition tests were employed. The compounds selected were tested in one-step growth cycle set-up. We established that N-phenyl-N′-4-hydroxyphenyl-thiourea (V-24) and N-phenyl-N′-2-carboxyphenylthiourea (V-17) have a distinct inhibitory effect on the growth of rhinovirus H-17, and N-phenyl-N′-2-hydroxy-5-nitrophenylthiourea (V-25) inhibited strongly the multiplication of rhinoviru

ISSN:0009-3157    

DOI:10.1159/000221975

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

The activity in vitro of tibezonium (Rec 15–0691), a new 1,5-benzo-diazepine derivative, has been investigated. The drug was found active especially against Streptococcus, Diplococcus and Corynebacterium strains which are agents of oropharyngeal diseases. The activity of tibezonium was pH dependent against Staphylococcus aureus SG 511 and Streptococcus pyogenes 821 (at pH 8.0–8.5 it was more active) and the presence of horse serum provoked a small decrease of the antimicrobial properties. No interference on the activity of the tibezonium has been found in presence of smokers and non-smokers sal

ISSN:0009-3157    

DOI:10.1159/000221976

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

The effect of pyrantel pamoate, levamisole, mebendazole, thiabendazole and bephenium hydroxynaphthoate on various intestinal helminths were evaluated among the inhabitants of four villages in the Dezful area southwest of Iran. A total number of 328 persons, all infected simultaneously with Ascaris and hookworm (Ancylostoma duodenale) and 49.2% with Trichostrongylus spp., were randomly divided into six groups. One group was kept as the control and the other five were each treated with one compound. Follow-up examinations showed that all of the drugs used were highly effective on Ascaris, and the differences in the cure rate were not statistically significant except for bephenium hydroxynaphthoate which showed a lower cure rate. For hookworm, cure rates of 100, 90, and 85% were observed with levamisole, pyrantel pamoate and bephenium hydroxynaphthoate, respectively. Cure rates observed with mebendazole and thiabendazole were 35 and 51%, respectively. For Trichostrongylus, the highest cure rate was achieved with levamisole, followed by thiabendazole and mebendazole. While the percentage of people showing side-effects was rather low for all drugs, thiabendazole and bephenium hydroxynaphthoate produced a higher, and levamisole a lower, percentage of side effects.

ISSN:0009-3157    

DOI:10.1159/000221977

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

We have treated 45 cases of urinary tract infection with cefazolin (i.m.) and cure was achieved in 35 (77.77%). 26 of the 28 patients (92.85%) with acute cystitis who received 250 mg every 12 h for 6–10 days were cured. 17 patients with pyelonephritis received 500 mg every 12 h during 10–14 days and therapeutical success was achieved in 9 of them (52.94%). Laboratory control was carried out at the initiation of therapy, at the end, and 1 month after therapy. Tolerance to injections of cefazolin was considered good and only in one case appeared a mild eosinophi

ISSN:0009-3157    

DOI:10.1159/000221978

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

Cephazolin has certain advantages over other systemic cephalosporins. It was given in a dose of 2–3 g daily for 7 days in 40 patients with severe purulent exacerbations of chronic bronchitis, 11 with purulent bronchiectasis and 24 with secondarily infected bronchial carcinoma. Most had failed to respond to high doses of other antibiotics. Results were very good and toxicity minima

ISSN:0009-3157    

DOI:10.1159/000221979

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

67 of the bacteriologically proved adult acute cholera patients have been examined in order to evaluate the efficacy of TM-SMX in comparison with tetracycline and chloramphenicol in the eradication of Vibrio cholerae from stools. Our results demonstrated that all three drugs sterilized the stools of all patients within 3 days with the exception of one case of TM-SMX’s group, which had negative culture stools after 4 days. On the basis of our experience it can be emphasized that TM-SMX can support chloramphenicol and tetracycline in the antibacterial treatment of cholera with the advantage that the drug is efficacious with daily administration

ISSN:0009-3157    

DOI:10.1159/000221980

出版商:S. Karger AG    

年代:1977

数据来源: Karger