ISSN:0009-3157    

DOI:10.1159/000221914

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

Therapy of chronic E. coli pyelonephritis in rats was equally effective with cyclacillin and oral ampicillin, whereas intramuscular ampicillin had a significantly higher therapeutic activity than oral cyclacillin. Serum concentrations in rats and mice were consistently higher with cyclacillin than with ampicillin and showed great variations depending on the animal species. It was concluded that there is a good correlation between in vivo and in vitro activity of both antibiotics, provided that the serum levels are taken into consideration. On this basis it may be predicted that in man cyclacillin will exhibit lower therapeutic activity in gram-negative infections than ampicillin.

ISSN:0009-3157    

DOI:10.1159/000221915

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

Methods are proposed which, in combination with those described in an earlier publication by the author, enable the separate determination of the two main types of sulfonamide metabolites, the N4-acetyl derivative and the conjugates, besides the total and the active sulfonamide in body fluids.

ISSN:0009-3157    

DOI:10.1159/000221916

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

A colorimetric method was modified to estimate the levels of benzylpenicillin and its penicilloic acid in urine. When benzylpeniciUin was given orally to healthy volunteers, both it and its penicilloic acid were detected in the urine. When benzylpenicillin was given by intramuscular injections to these volunteers, only benzylpenicillin was detected in the urine. Patients suffering from chronic bronchial infections that exhibited β-Lactamase producing gram-negative bacteria in their sputum were given benzylpenicillin intramuscularly. It was found that both benzylpenicillin and penicilloic acid were recovered from the urine of such patients

ISSN:0009-3157    

DOI:10.1159/000221917

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

The occurrence of drug-resistant coliform bacteria was studied in the faecal flora of 30 persons receiving for 3 weeks either trimethoprim alone, a combination of sulphamethoxazole and trimethoprim, or a combination of sulphamethox-ydiazine and sulphamethoxazole. Bacterial sensitivity was tested against trimethoprim, sulphamethoxazole-trimethoprim, sulphamethoxazole, and sulphaisodimidine. After treatment with trimethoprim alone, no increase in the occurrence of strains resistant to either trimethoprim or sulphonamides was observed. After treatment with sulphamethoxazole-trimethoprim, the faecal flora contained an increased percentage of sulphonamide-resistant coliforms but significantly less than found after treatment with sulphamethoxydiazine-sulphamethoxazole. In the persons receiving the sulphonamides only, a rapid increase in sulphonamide-resistant coliforms was observed. During the whole study, only one trimethoprim-resistant coliform strain was detected.

ISSN:0009-3157    

DOI:10.1159/000221918

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

Exposure of Serratia marcescens cells to 10, 5, and 2.5 μg/ml of polymyxin B resulted in outer cell surface alterations that consisted of coarse, pleomorphic projections which revealed a double-contoured membrane structure. In contrast, fresh, but not heat-inactivated human serum caused the deposition of very fine, thread-like aggregates on the outer cell surface of exposed cells. The combination of polymyxin B and fresh human serum caused clearly discernible ultrastructural changes of the polymyxin and the fresh serum type, respectively

ISSN:0009-3157    

DOI:10.1159/000221919

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

Three antiviral 1,3,4-thiadiazoles caused, when incubated together with 3H-uridine, a reduction of the incorporation rate into acid-insoluble material of FL cells. Using the method of prelabelling cellular RNA synthesis was not remarkably influenced. However, the substances tested act as specific inhibitors of the virus-induced RNA synthesis.

ISSN:0009-3157    

DOI:10.1159/000221920

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

Fosfomycin was exclusively used as antibiotic treatment in 37 patients suffering from osteomyelitis, out of which 23 were operated for sequestrectomy or fistulectomy, whereas the remaining 14 did not undergo any surgery during fosfomycin treatment. Fosfomycin was administered parenterally, alone or combined with oral administration, and in some cases only orally. The dosage varied from 4 to 8 g/day for an average period of 3 weeks. After one or two treatments the results were 29 definitive cures (78%), 2 failures and 6 relapses (22%).

ISSN:0009-3157    

DOI:10.1159/000221921

出版商:S. Karger AG    

年代:1976

数据来源: Karger

ISSN:0009-3157    

DOI:10.1159/000221922

出版商:S. Karger AG    

年代:1976

数据来源: Karger