摘要:

Death due to heroin overdose and/or rapid injection of heroin is a frequent occurrence among opioid addicts. We present an unusual case of heroin fatality due to the injection of the drug in the penis. Blood, urine, bile, and vitreous humor concentrations of morphine were 0.68, 0.49, 0.32 and 0.062 μg/ml, respectively. Ethanol was detected at concentrations of 104, 124, 106, and 94 mg/dl in the blood, urine, bile, and vitreous humor, respectively. The cause of death was determined to be due to heroin and ethanol intoxication.

ISSN:0195-7910    

出版商:OVID    

年代:1999

数据来源: OVID

摘要:

We report a midazolam-related death that occurred during endoscopic retrograde cholangiopancreatography (ERCP). The acute intoxication due to midazolam overdose was confirmed by high-pressure liquid chromatography (HPLC) analysis of the blood samples taken from the patient in the intensive care unit (2.8 μg/ml) and postmortem (2.4 μg/ml). The case strongly emphasizes the necessity of the precautions that should be taken when midazolam is intravenously administered.

ISSN:0195-7910    

出版商:OVID    

年代:1999

数据来源: OVID

摘要:

Tramadol (Ultram) is a centrally acting, synthetic analgesic agent. Although it has some affinity for the opiate receptors, tramadol is believed to exert its analgesic effect by inhibiting the re-uptake of norepinephrine and serotonin. There are several published cases of tramadol's involvement in drug-related deaths and impairment. Reports of deaths involving tramadol alone with associated tissue concentrations are rare. This report documents a case in which tramadol overdose was identified as the cause of death. The following tramadol concentrations were found in various tissues: blood, 20 mg/L; urine, 110.2 mg/L; liver, 68.9 mg/kg; and kidney, 37.5 mg/kg. Tissue distributions of the two primary metabolites,N-desmethyl andO-desmethyl tramadol, are also reported. In each tissue or fluid except urine, the tramadol concentration was greater than either metabolite, consistent with other reports of drug-impaired drivers and postmortem cases. TheO-desmethyl metabolite concentration was greater than theN-desmethyl metabolite concentration in all tissues; this is in contrast to other postmortem reports, in which the majority of cases report concentrations ofO-desmethyl as less than those ofN-desmethyl. This may be useful as an indicator of time lapse between ingestion and death.

ISSN:0195-7910    

出版商:OVID    

年代:1999

数据来源: OVID

ISSN:0195-7910    

出版商:OVID    

年代:1999

数据来源: OVID

ISSN:0195-7910    

出版商:OVID    

年代:1999

数据来源: OVID

ISSN:0195-7910    

出版商:OVID    

年代:1999

数据来源: OVID

ISSN:0195-7910    

出版商:OVID    

年代:1999

数据来源: OVID