摘要:

The effect of the dosing schedule on aminoglycoside ototoxicity was investigated in the guinea pig. The animals were given amikacin or isepamicin either by once-daily intramuscular injection of 200 mg/kg or by twice-daily injections of 100 mg/kg for 28 days. The once-daily treatment induced a lesser degree of ototoxicity than the twice-daily injections, which may indicate that the once-daily treatment therapy has a potential value in the clinical use of aminoglycoside antibiotics. Isepamicin sulfate is a new aminoglycoside antibiotic currently undergoing clinical investigation. This study revealed that isepamicin also has ototoxic properties as has been observed in all other aminoglycosides. The degree of ototoxicity, however, was markedly less than that of amikacin.

ISSN:0301-1569    

DOI:10.1159/000276162

出版商:S. Karger AG    

年代:1990

数据来源: Karger

摘要:

Measurements of the auditory brainstem responses (ABR) were used to assess the functional integrity of the brainstem auditory pathways following open-heart surgery. Recording of ABR was performed in 31 patients before and after open-heart surgery. The values of ABR measurements were compared to those of a control group of normal-hearing subjects. Postoperative aberrations in ABR were observed in 12 patients. Brainstem transmission time measured as wave I to wave V interpeak latency (I-V IPL) was prolonged in 6 patients and shortened in 8 patients. Concomitant impairment in hearing function was not present, and therefore, these changes most probably reflected a functional alteration in the neurological status of the brainstem. Possible explanations of the postoperative changes in I-V IPL are discussed, however, further studies are needed to clarify the pathogenesis of these changes. Measurement of ABR may prove to be an important adjunct in the overall assessment of the neurological status following open-heart surgery.

ISSN:0301-1569    

DOI:10.1159/000276163

出版商:S. Karger AG    

年代:1990

数据来源: Karger

摘要:

In 3 years, a total of 1,291 patients have undergone equilibrium examinations because of vertigo, dizziness and disequilibrium in the Otoneurological Division of Toyama Medical and Pharmaceutical University. Abnormal blood pressures (hypertension, hypotension and orthostatic hypotension) were found in 18.67% (241 patients). Hypotension was found significantly more often in peripheral vestibular disorders and hypertension in central nervous system disorders. Furthermore, the incidence of orthostatic hypotension was statistically higher in hypertensive patients than in hypotensive patients. Therefore, we conclude that blood pressure measurement by the Schellong test method in patients with vertigo, dizziness and disequilibrium is very important.

ISSN:0301-1569    

DOI:10.1159/000276164

出版商:S. Karger AG    

年代:1990

数据来源: Karger

摘要:

The amplitude ratio between the paretic and the normal side as determined by electroneuronography is used as a basis for estimating the prognosis of facial palsy. Several methods have been described of placing the surface electrodes and of finding the supramaximal impulse strength. We investigated 16 normal test persons with the aim (1) of optimizing the procedure of neuronography with regard to the possible variations of electrode placement and stimulus intensity and (2) of finding out the right/left difference in normal test subjects. Following our results, the best positions of the recording electrodes are the nasal alae. Even under these most favorable test conditions we found an average side difference of the bilaterally recorded electroneurograms of normal test persons of 22 %.

ISSN:0301-1569    

DOI:10.1159/000276165

出版商:S. Karger AG    

年代:1990

数据来源: Karger

摘要:

Human nasal epithelial cells, which lost their cilia in monolayer cultures, redeveloped cilia after 1 week in a suspension culture system. Before ciliogenesis started, the number of microvilli increased. Primary cilia were absent. The different cytoplasmic stages of this in vitro ciliogenesis could be reconstructed here into a sequence of events comparable to that described in the embryogenesis of the mammalian respiratory tract. In addition to the fibrogranular aggregates, deuterosomes with procentrioles and kinetosomes, small tubular structures in the fibrogranular aggregates could be visualized. The formation of the ciliary shaft above an aligned basal body started as an elevation of the apical membrane without any recognizable axonemal ultrastructure. This study provides the first full description of in vitro ciliogenesis on a human tissue.

ISSN:0301-1569    

DOI:10.1159/000276166

出版商:S. Karger AG    

年代:1990

数据来源: Karger

摘要:

Arterial hypertension was found in 78 of 224 consecutive patients operated for nasal polyposis. An exacerbated degree of hypertension was significant in groups aged above 50 years. In total, 46% of patients whose nasal polyposis was of a duration of more than 10 years suffered from hypertension. Fifty of 78 patients developed hypertension after nasal polyposis was established and the mean duration time from polyposis to hypertension was 11.1 years. Hypertension was established in 50% of patients suffering from the triad asthma, intolerance to acetylsalicylic acid and nasal polyposis. In analogy with knowledge that sleep apnoea and snoring are aetiological factors for arterial hypertension, we propose that longstanding nasal obstruction by nasal polyposis be a risk factor for arterial hypertension.

ISSN:0301-1569    

DOI:10.1159/000276167

出版商:S. Karger AG    

年代:1990

数据来源: Karger

摘要:

Hemangiomas of bone are rare tumors in the facial region. In our own case, magnetic resonance imaging showed unique linear high-signal-intensity internal components in T1-weighted images. The histological study demonstrated that adipose tissue occurring in the stroma of the tumor caused the high signal intensity in T1-weighted images. We employed a vascularized calvarial bone flap to reconstruct the malar eminence after resection of the tumor.

ISSN:0301-1569    

DOI:10.1159/000276168

出版商:S. Karger AG    

年代:1990

数据来源: Karger

摘要:

We present the cases of 3 previously healthy patients who became ill with a very sudden and painful external otitis due to Pseudomonas aeruginosa. At the acute stage, diagnosis was difficult in all these patients because of marked periauricular swelling and radiological mastoiditis. The latter sign has not been reported earlier in association with external otitis in nonimmunocompromised patients. All patients made a full recovery with appropriate treatment.

ISSN:0301-1569    

DOI:10.1159/000276169

出版商:S. Karger AG    

年代:1990

数据来源: Karger

ISSN:0301-1569    

DOI:10.1159/000276170

出版商:S. Karger AG    

年代:1990

数据来源: Karger

ISSN:0301-1569    

DOI:10.1159/000276171

出版商:S. Karger AG    

年代:1990

数据来源: Karger