摘要:

Five specimens of the endolymphatic sac taken from patients with Ménière’s disease during epidural drainage surgery were examined under the electron microscope. The clinical history and histopathological findings are presented. The most common and prominent finding was perisaccular fibrosis of the endolymphatic sac which appears to disturb the free absorption of endolymph in the endolymphatic sac resulting in endolymphatic hydrops. Well-preserved epithelial cells of the endolymphatic sac could only be found in one of the specim

ISSN:0301-1569    

DOI:10.1159/000275533

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

The authors describe a clinical approach to the diagnosis and treatment of sensory-neural hearing loss associated to the Mondini dysplasia. The first element of diagnostic suspicion was represented either by a history of fluctuant and progressive hearing loss or by electrocochleography patterns showing multiple-peaked acoustic nerve action potentials similar to those observed in Ménière’s disease. Confirmation of the diagnosis was obtained by temporal bone polytomography. An endolymphatic subarachnoid shunt was performed in 22 ears of 18 patients. The results, although preliminary, suggest that the shunt effectively contributes to stabilize the hearing and arrest the further progression of the hearing l

ISSN:0301-1569    

DOI:10.1159/000275534

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

During a 1 -year period, 151 children, ½–6 years old, attending group care, were followed by monthly tympanometry in order to describe spontaneous variations in the tympanograms in relation to age and time of the year. Furthermore, the number of spontaneous variations during the year was assessed. Significantly more flat curves were seen in children ½–1 year old than in the older age groups, indicating a high frequency of spontaneous remission about the age of 2 years. In all age groups more normal tympanograms were seen during late summer than during the rest of the year. Spontaneous variations in the tympanograms were taking place 2.9 times (mean) during the period of observation. Correlation was found between the presence of catarrh and flat curves. Furthermore, in children ≧ 3 years old, a correlation between case history signs of enlarged adenoids and flat curves lasting for 3 months or more was found. It was concluded that persistence of flat curves in children ½–1 (2) years old usually requires no treatment, as spontaneous remission can be expected, whereas persistence of flat curves for > 3 months in children ≧ (2) 3 years old indicates that treatment (adenoidectomy) should

ISSN:0301-1569    

DOI:10.1159/000275535

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

Repetitive tympanometric screenings of 4-year-old children were performed in February, May, and August 1979, in order to determine prevalence and seasonal variation of secretory otitis and tubal dysfunction. In February, the prevalence of type B was 14%, by August it was significantly improved. Between trials, 50% of ears changed tympanogram type, indicating great variations in the tympanometric conditions. From winter to spring, the tympanogram types improved significantly, but not from spring to summer, which was primarily due to the fact that the summer of 1979 was especially rainy and cold. Compared with 2-year-old children, the prevalence was higher and the spontaneous recovery less pronounced in 4-year-old children, though also in this age group type B improved spontaneously in nearly half of the ears.

ISSN:0301-1569    

DOI:10.1159/000275536

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

Domperidone, administered to rabbits, is able to reduce the duration of a rotation-induced nystagmus. In human volunteers a similar effect was found in a double blind study, in which single doses of 10, 20 and 40 mg were given orally. As electronystagmographic recordings were made during the rotation test at different time intervals after drug intake, the different dosages became comparable. The reduction of the nystagmus duration proved to be dose-dependent, whereas the peak velocity of the slow nystagmus component remained unchanged. The strongest effect of the drug appeared 60 min after intake, the effect lasted about 4 h. A mechanism of action different from that of cinnarizine and flunarizine is assumed because these drugs likewise influence the duration and the slow velocity component of nystagmus.

ISSN:0301-1569    

DOI:10.1159/000275537

出版商:S. Karger AG    

年代:1981

数据来源: Karger