摘要:

A study on the effect of war on the suicide rate in Jaffna town for the 10‐year period from 1980 to 1989 is reported. There was a marked drop in the suicide rate during the war, notably among males and youth. An inverse relationship between suicide and homicide rates was shown in the overall trends, particularly in 1987. It is hypothesized that war may function as an alternate to suicide. The use of agrochemicals for suicidal purposes declined during war, while alary seeds became more popular. The method chosen may reflect availability and cultural popularit

ISSN:0001-690X    

DOI:10.1111/j.1600-0447.1995.tb09733.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

ISSN:0001-690X    

DOI:10.1111/j.1600-0447.1995.tb05924.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

ISSN:0001-690X    

DOI:10.1111/j.1600-0447.1995.tb05925.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

The concept of reversible type A monoamine oxidase (MAO‐A) inhibitors as effective antidepressant drugs with a minimal side effect profile has been vindicated in practice. Despite this, the pharmacological basis for their actions is unclear. Studies with the irreversible inhibitor clorgyline have shown that chronic but not acute treatment of rats leads to a significant enhancement of noradrenaline release from peripheral sympathetic nerves and cerebral cortex together with a more effective inhibition of MAO‐A, as shown by reduction in levels of deaminated metabolites in cortical microdialysis fluid. Reversible inhibitors, however, do not have a cumulative effect on MAO inhibition and may have different effects on noradrenaline release. Reversible inhibitors did not produce the acute reduction in sympathetic nerve activity seen with clorgyline, which may be one factor in explaining their milder side effect profile. Other aspects of the pharmacology of reversible and irreversible selective inhibitors of MAO‐A are rev

ISSN:0001-690X    

DOI:10.1111/j.1600-0447.1995.tb05918.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

ISSN:0001-690X    

DOI:10.1111/j.1600-0447.1995.tb05926.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

摘要:

Noradrenaline (NA) and serotonin, monoamines that increase neurotransmission at the monoaminergic synapses, remain primary targets for antidepressant drugs. To help elucidate NA's role in the action of antidepressants, a model was set up allowing for a simulation of NA turnover under various conditions examining 3 compartments: newly synthesized vesicular NA, released synaptic NA, and vesicular NA reuptake across neuronal membranes. We compared the influence of the reversible MAO inhibitor, moclobemide, and the NA reuplake inhibitor, desipramine, both useful in regaining baseline synaptic NA concentrations. Moclobemide appears less sensitive to fluctuations either in drug concentrations and/or physiological determinants of NA turnover; we conclude that it may influence brain function in a more regulatory way than reuptake inhibitors.

ISSN:0001-690X    

DOI:10.1111/j.1600-0447.1995.tb05919.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

ISSN:0001-690X    

DOI:10.1111/j.1600-0447.1995.tb05927.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

ISSN:0001-690X    

DOI:10.1111/j.1600-0447.1995.tb05928.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

ISSN:0001-690X    

DOI:10.1111/j.1600-0447.1995.tb05929.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY

ISSN:0001-690X    

DOI:10.1111/j.1600-0447.1995.tb05930.x

出版商:Blackwell Publishing Ltd    

年代:1995

数据来源: WILEY