摘要:

A retrospective study was made, investigating the post‐treatment outcomes of patients in two apparently dissimilar psychiatric therapeutic centres in Nigeria: the Aro Mental Hospital, a custodial facility, and the Aro Community Village Program, a pilot experiment in community psychiatry. A matched sample of 208 treated patients and their next of kin was focussed upon. An organizational study of the milieux was also undertaken. No significant differences exist in the range of therapies which was administered to schizophrenic patients or in the rate of re‐admission in the two therapeutic milieux. A significantly greater percent of patients were treated for over 3 months on first admission in the community centre than in the hospital centre (P<0

ISSN:0001-690X    

DOI:10.1111/j.1600-0447.1977.tb00135.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

Lofepramine, an imipramine analogue, was compared with imipramine in a multicentre, double‐blind clinical trial. The 62 patients (31 in each of two treatment groups) had a depressive syndrome that normally would have been treated with a tricyclic antidepressant. These patients had not received any adequate treatment for their present depressive episode. After a wash‐out period and once a week during treatment (up to 5 weeks), routine laboratory tests and electrocardiograms were done. The dosage was 50 mg t.i.d. for imipramine and 70 mg t.i.d. for lofepramine.Depression ratings with the Cronholm‐Ottosson depression rating scale were performed before treatment and once weekly for 3 weeks and then in the 5th week. The last four ratings were combined with rating of side‐effects.In the 5th week of treatment 15 out of 31 in the lofepramine group and 18 out of 31 in the imipramine group had recovered. This difference was not significant, nor did the median values of individual symptoms differ between the groups. The side‐effects were moderate and the two groups only differed significantly in the items “dry mouth” and accommodation disturbances in favour of lofepramine. The drug compliance was checked by plasma levels of desmethylimipramine in the imipramine group, parent compound, and “apparent” desmethylimipramine in the lofepramine group.The relationship between plasma drug levels, the effect on noradrenaline uptakein vitroand amelioration is discussed inSiwers et al. (1977) in this issue.The clinical outcome in the two groups did not differ significantly; interpretation of this result is discussed in relation to the reliability of rating and sele

ISSN:0001-690X    

DOI:10.1111/j.1600-0447.1977.tb00136.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

ISSN:0001-690X    

DOI:10.1111/j.1600-0447.1977.tb10802.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

ISSN:0001-690X    

DOI:10.1111/j.1600-0447.1977.tb10803.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

ISSN:0001-690X    

DOI:10.1111/j.1600-0447.1977.tb10804.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

A multicentre comparative clinical evaluation of lofepramine, an imipramine analogue, and imipramine has been made with double blind technique and fixed dosage (lofepramine 70 mg t.i.d., imipramine 50 mg t.i.d.). Plasma was drawn after 3 weeks for determination of noradrenalhe‐uptake inhibitory capacity of the parent compound and or its active metabolites. Plasma concentrations of lofepramine and desmethylimipramine (DMJ) were determined in the same samples. The concentrations of lofepramine in the whole material were low (5–27 nglml) except for one patient who had a level of 53 ng/ml. In both groups of patients there was an almost 40‐fold range in the plasma levels of DMI or a parent DMI. The patients were rated for severity of depression before treatment, then once weekly for 3 weeks and finally during the Hth weak. For further information concerning the psychiatric aspects, seedElia et al. in this issue (1977). A significant correlation was found between the concentrations of DMI and the noradrenalinauptake inhibitory capacity in the plasma sample. No correlations were found between uptake inhibitory capacity of plasma samples and the amelioration s

ISSN:0001-690X    

DOI:10.1111/j.1600-0447.1977.tb00137.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

ISSN:0001-690X    

DOI:10.1111/j.1600-0447.1977.tb10805.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

ISSN:0001-690X    

DOI:10.1111/j.1600-0447.1977.tb10806.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

ISSN:0001-690X    

DOI:10.1111/j.1600-0447.1977.tb10807.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY

摘要:

The present study is concerned with the outcome of long‐germ lithium maintenance therapy administered to 107 manic‐depressive patients after more than 12 months. Nine patients failed to respond despite having met the criteria for maintenance within the therapeutic range of lithium. This group, termed “lithium non‐responders”, had all shown bipolar illness with gross morbidity with frequent cycles,>4 per year, seven had a family history of affective illness (six bipolar). The study did not demonstrate any other clear factors common to the “non‐resp

ISSN:0001-690X    

DOI:10.1111/j.1600-0447.1977.tb00138.x

出版商:Blackwell Publishing Ltd    

年代:1977

数据来源: WILEY