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1. |
Evaluation of a Significantly Shorter Version of the Farnsworth‐Munsell 100‐Hue Test in Patients with Three Different Optic Neuropathies |
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Journal of Neuro-Ophthalmology,
Volume 17,
Issue 1,
1997,
Page 1-6
Brian Nichols,
H. Thompson,
Edwin Stone,
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摘要:
We tested the hypothesis that a subset of the Farnsworth-Munsell 100-hue test (FM-100) would be a sensitive, specific, and practical means of monitoring color vision in patients with chronic optic nerve disorders. We retrospectively analyzed the records of 1,113 patients affected with optic neuritis (ON), Graves' ophthalmopathy with suspected optic neuropathy, or idiopathic intracranial hypertension with suspected optic neuropathy (ON). One hundred six records of patients showed that an FM-100 had been performed (23 ON, 46 Graves', 37 IIH). Forty additional patients were studied prospectively (11 ON, 17 Graves', 12 IIH). The sensitivity and specificity of all possible 21 chip subtests were compared against the same statistics for the entire test. We found that for these three optic nerve disorders, a test consisting of chips 22–42 had nearly the same sensitivity and specificity as the entire test when compared with the clinical diagnosis. At 90% specificity, the ratio of sensitivities of the short version to the original version of the test were IIH, 53%/45%; optic neuritis, 85%/79%; and Graves', 67%/70%. The majority of the clinical value of the test can be achieved in one fourth of the original examination time.
ISSN:1070-8022
出版商:OVID
年代:1997
数据来源: OVID
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2. |
The Effect of Edrophonium Chloride on Muscle Balance in Normal Subjects and Those with Nonmyasthenic Strabismus |
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Journal of Neuro-Ophthalmology,
Volume 17,
Issue 1,
1997,
Page 7-11
R. Siatkowski,
Lavanya Shah,
William Feuer,
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摘要:
Because the Lancaster red-green test and the Hess screen are not widely used by most ophthalmologists, we used the alternate prism-cover test to study the effect of intravenous edrophonium chloride (Tensilon) on the ocular alignment of 30 normal subjects and 14 individuals with nonmyasthenic strabismus. After measurement of their baseline phorias and tropias, patients received an intravenous injection of Tensilon via the incremental dose technique until autonomic effects of the drug were noted or until 10 mg was administered. Another set of measurements of muscle balance was taken immediately postinjection and 2 and 5 min later. Apart from a small increase (mean, 2 prism dipoters;p= 0.004) in their exophoria at near, normal subjects exhibited no significant change in their phorias after Tensilon injection. One third to one half of the nonmyasthenic strabismics, however, showed a change in their vertical deviation after Tensilon (46% at distance and 38% at near), with the majority of them increasing their angle of squint. These changes were small (mean, 1.7 prism diopters; maximum, 5 prism diopters). In only one case did reversal of the direction of deviation occur. Tensilon produces a statistically significant increase in near exophorias of normal subjects and in vertical distance deviations of nonmyasthenic strabismics. These changes, however, are clinically insignificant and should not be considered to constitute a positive Tensilon test.
ISSN:1070-8022
出版商:OVID
年代:1997
数据来源: OVID
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3. |
Frequency‐Selective Fat Suppression MR ImagingLocalized Asymmetric Failure of Fat Suppression Mimicking Orbital Disease |
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Journal of Neuro-Ophthalmology,
Volume 17,
Issue 1,
1997,
Page 12-17
Alexandra Borges,
Robert Lufkin,
Anthony Huang,
Keyvan Farahani,
Anthony Arnold,
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摘要:
Our objectives were to further characterize an artifact related to the localized failure of the frequency-selective (FATSAT) fat suppression magnetic resonance (MR) imaging technique. We constructed two phantoms simulating human orbital anatomy and imaged them on a 1.5-T MR scanner using (FATSAT) and short T1 inversion recovery (STIR) techniques of fat suppression. The first phantom resembled orbit structural configurations; it was imaged in coronal and axial planes and in varying orientations with respect to the main magnetic field (Z axis) to study the features of the artifact and to reproduce the asymmetry seen in clinical cases. We designed the second phantom to enable quantification of the change in artifact size with change in orientation. We imaged the orbits of a normal human volunteer in similar planes and orientations, and compared the results to clinical cases demonstrating the artifact and true orbital disease. The artifact identified with localized failure of FATSAT fat suppression manifested as regions of hyperintensity maximal at fat-air interfaces, with gradual fading of the increased signal with distance from the interfaces. The artifact was most prominent when the interfaces were perpendicular to the axis of the main magnetic field (Z axis). The regions of increased brightness obscured normal orbital structures but were not associated with alterations in the geometry of these structures. Changes in orientation of the interfaces with respect to the Z axis, both in the phantoms and normal volunteer, reproduced the asymmetry of fat suppression failure seen in clinical cases. The relationship of size of the artifact to change in orientation was nonlinear. The artifact was not seen on STIR images. We concluded that failure of FATSAT fat suppression may mimic orbital disease, particularly if asymmetric. As predicted by the Maxwell electromagnetism equation, slight variations in orientation of the fat-air interface to the Z axis may produce large asymmetries in fat suppression failure in the orbit. Confirmation may require either comparison with additional pulse sequences [T1-weighted spin echo (T1W SE) or STIR] or repositioning the patient's head to check for persistence of the finding with varying orientations.
ISSN:1070-8022
出版商:OVID
年代:1997
数据来源: OVID
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4. |
Visual Symptoms After Optic NeuritisResults from the Optic Neuritis Treatment Trial |
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Journal of Neuro-Ophthalmology,
Volume 17,
Issue 1,
1997,
Page 18-28
Patricia Cleary,
Roy Beck,
Linda Bourque,
Jye-yu Backlund,
Päivi Miskala,
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摘要:
As part of the Optic Neuritis Treatment Trial, vision-specific quality-of-life data were collected on the patients at their 6-month visits. The purpose of this study was to determine the types of visual tasks in day-to-day living in which patients have difficulty and to compare the patients' subjective assessment of visual impairment with measurements of visual acuity, contrast sensitivity, mean deviation, and color vision. The questionnaire was completed by 382 (87%) of the 438 patients who had 6-month study visits. Associations between ophthalmic test scores and self-reported vision were examined using both a summary problem index and selected individual items. Although a substantial percentage of the patients (63%) indicated that vision had not recovered to normal in the affected eye, the reported visual deficits generally were mild. For most of the visual tasks of daily living, patients reported little or no problem. Among the 215 patients who perceived their vision at 6 months to be somewhat or much worse than it was before optic neuritis, 20% had normal results on none of the four visual function tests, 14% had normal results on one of the four tests, 23% had two of four, 23% had three of four, and 20% had normal results on all four. Reported visual symptoms 6 months after optic neuritis generally were mild. When patients were symptomatic, the four visual function tests often did not detect abnormality. This finding supports previous reports that visual deficits are frequently perceived even when vision testing is normal.
ISSN:1070-8022
出版商:OVID
年代:1997
数据来源: OVID
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5. |
Asymptomatic Optic Disc Edema |
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Journal of Neuro-Ophthalmology,
Volume 17,
Issue 1,
1997,
Page 29-32
Richard Gordon,
Ronald Burde,
Thomas Slamovits,
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摘要:
Non-arteritic anterior ischemic optic neuropathy (AION-na) classically presents with visual loss, altitudinal visual field defects, and optic nerve swelling. AION-na presumably occurs secondary to an ischemic event. Two patients are described who were at risk for developing AION-na. Both patients presented with optic disc edema but did not have visual loss or visual field defects. Neither patient developed visual loss or visual field defects in the affected eye throughout one and two years of follow-up respectively. The optic disc edema resolved spontaneously in both affected eyes. The clinical spectrum of AION-na could range from a “full-blown” classic attack to a minimal attack characterized by disc swelling without visual loss. The amount and distribution of disc ischemia determines the individual clinical picture. The failure of either affected eye in this study to develop symptoms likely represents a graded axonal atrophy with mechanical decompression of the optic nerve.
ISSN:1070-8022
出版商:OVID
年代:1997
数据来源: OVID
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6. |
Cataract in Tuberous Sclerosis |
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Journal of Neuro-Ophthalmology,
Volume 17,
Issue 1,
1997,
Page 33-35
Judith Warner,
Simmons Lessell,
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摘要:
We evaluated two patients with tuberous sclerosis (TS) and cataracts. In one, the cataract had been noted at an early age. In the second, it was noted at her first ophthalmic examination, age 31. Review of the literature indicates that although in some cases, cataract is attributable to local ocular disease, it may be a rare manifestation of TS.
ISSN:1070-8022
出版商:OVID
年代:1997
数据来源: OVID
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7. |
Bilateral Visual Loss and Simultagnosia After Lumboperitoneal Shunt for Pseudotumor Cerebri |
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Journal of Neuro-Ophthalmology,
Volume 17,
Issue 1,
1997,
Page 36-38
Neil Miller,
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ISSN:1070-8022
出版商:OVID
年代:1997
数据来源: OVID
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8. |
Nemaline MyopathyAn Unusual Cause of Ophthalmoparesis |
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Journal of Neuro-Ophthalmology,
Volume 17,
Issue 1,
1997,
Page 39-43
R. Wright,
Gordon Plant,
David Landon,
John Morgan-Hughes,
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摘要:
Ophthalmoparesis and ptosis are extremely rare in nemaline myopathy. A 45-year-old man with a long history of bilateral ptosis and a 1-year history of diplopia is reported. Leg and arm weakness and wasting had been present since childhood, with a very slow deterioration over time. On examination, there was nonfatigueable bilateral ptosis that was more marked on the right. There was diplopia on left gaze. Extraocular movements showed limitation of elevation and adduction of the right eye. There was bilateral facial weakness, as well as proximal and distal wasting and weakness in the arms and legs.Electromyography (EMG) showed a combination of myopathic and neurogenic changes. Triceps muscle biopsy showed small multiple collections of rod-like structures in >50% of fibers. This patient presented with a clinical picture that did not primarily suggest nemaline myopathy. This case illustrates the heterogeneity of this disorder and the need for muscle biopsy to make an accurate diagnosis in patients with ptosis and progressive external ophthalmoparesis.
ISSN:1070-8022
出版商:OVID
年代:1997
数据来源: OVID
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9. |
Chronic Internuclear OphthalmoplegiaA Manifestation of D‐penicillamine Cerebral Vasculitis |
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Journal of Neuro-Ophthalmology,
Volume 17,
Issue 1,
1997,
Page 44-46
Misha Pless,
Thomas Sandson,
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ISSN:1070-8022
出版商:OVID
年代:1997
数据来源: OVID
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10. |
Fourth Nerve Palsy Caused by Ehrlichia chaffeensis |
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Journal of Neuro-Ophthalmology,
Volume 17,
Issue 1,
1997,
Page 47-50
Nathaniel Carter,
Neil Miller,
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摘要:
Two human ehrlichioses occur in the United States: human monocytic ehrlichiosis (HME), which is caused byEhrlichia chaffeensisthat infects mononuclear phagocytes in blood and tissue, and human granulocytic ehrlichiosis (HGE), an infection of granulocytes that is caused by a similar but phylogenetically distinct organism. The clinical features of both forms of human ehrlichiosis are identical and include nonspecific constitutional manifestations, such as fever, headache, malaise, nausea, vomiting, myalgia, and anorexia; however, rare patients develop neurologic symptoms and signs. Few cases of human ehrlichiosis have been described in detail, and focal neurologic deficits have only rarely been reported in such cases. We describe a patient with HME who developed a trochlear nerve paresis associated with evidence of lymphocytic meningitis during the course of her illness. We believe this to be the first well-documented case of a focal neurologic complication of human ehrlichiosis.
ISSN:1070-8022
出版商:OVID
年代:1997
数据来源: OVID
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