摘要:

SynopsisTo assess ocular irritancy caused by chemical and cosmetic products a reliable method based on evaluation of histamine (Hm) in tears is presented. Hm is measured at picomole levels by HPLC and fluorimetric detection after fluorescamine‐HM derivatization. In order to avoid any uncontrolled irritation and stimulation of the conjunctiva during sample collection, a procedure of conjunctiva lavage was developed. A balanced salt solution (50 μl) containing a known amount of Hm‐fluorophore as reference standard is instilled in the conjunctiva fornix. After a few seconds 20 μl of tear fluid is collected: 10 μl are immediately analysed and 10 μl after derivatization reaction. In this way it is possible to evaluate tear dilution and to assess Hm content in less than 10 minutes.In a group of 20 normal subjects Hm has been determined in comparison with that of two volunteers after topical application of 50 μ of 0.2% and 0.4% sodium lauryl sulphate solution. A contact of 30 seconds of the cosmetic ingredient caused an immediate dose‐dependent Hm release through a direct cytotoxic damage of cell membranes due to the surfactant action.Évaluation de l'irritation occulaire due aux cosmétiques par la détermination de l'hista

ISSN:0142-5463    

DOI:10.1111/j.1467-2494.1985.tb00389.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

SynopsisChemical microbial inhibitors compatible with formulations of soaps and deodorant perfumes are more effective if they are substantive to the skin. However, highly effective inhibitors are toxic and their substantivity on skin may accentuate the toxicity. Natural compounds such as short to medium chain fatty acids and their derivatives, which are known to be germicidal, offer a viable alternative to chemical inhibitors. We report here the synthesis of sodium 2‐lauroyloxy propionate and anin vivomethod to test its substantivity on skin following its incorporation in soaps. Among several compounds tested, sodium 2‐lauroyloxy propionate was found to be highly substantive in soap formulation.Propriétés antibactériennes d'un savon contenant des esters d'acid

ISSN:0142-5463    

DOI:10.1111/j.1467-2494.1985.tb00390.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

SynopsisThe mechanism of colour change during the pigment dispersion process and during powder application to the skin surface was studied by examining the colour extension properties ofYellow. Red, andBlackiron oxides in white powder bases. A new measure for the evaluation of the degree of colour extension was devised. This measure corresponded well with human visual sensation, and was found to be useful for comparing the rates of colour extension of pigments. The rate of colour extension of pigments was found to vary in the order:YellowacicularRedgranularRedBlack.This result explains colour darkening and the change towards reddish tones during the pigment dispersion process, becauseYellowextends fully in the early stage of the process butRed, especially in granular form, andBlackcontinue to extend even in the later stage. AcicularRediron oxide is more favourably employed than the granular form to attain sufficient colour extension of foundations with lower energy expenditure, and to decrease the discrepancy between the cake colour and the colour of applied powder.Le développement des oxydes de fer et effet sur les nuances des fonds de teint compact

ISSN:0142-5463    

DOI:10.1111/j.1467-2494.1985.tb00391.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

摘要:

RésuméL'activité antiséborrhéique de la sébathionine a étéétudiée sur la glande costovertébrale de hamster mâle castré et supplémenté en testostérone. Le test utilisé est l'incorporation de précurseurs marqués de la synthése lipidique.Le glucose comme l'acétate de sodium voient leur vitesse d'incorporation diminuer sous l'influence de la sébathionine. L'emploi d'un faux précurseur: le déoxyglucose montre que le produit agit de façon non spécifique sur la synthése lipidique.Cependant, au niveau de la synthése des acides gras, on peut préciser que l'action se situe au niveau des mécanismes d'allongement des chaines carbonées et non au niveau des processus de désaturation.Activity and mechanism of sebathio

ISSN:0142-5463    

DOI:10.1111/j.1467-2494.1985.tb00392.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

ISSN:0142-5463    

DOI:10.1111/j.1467-2494.1985.tb00393.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY

ISSN:0142-5463    

DOI:10.1111/j.1467-2494.1985.tb00394.x

出版商:Blackwell Publishing Ltd    

年代:1985

数据来源: WILEY