摘要:

RésuméUne émulsion multiple L/H/L contenant de l'huile d'amande douce en phase interne et de la paraffine liquide légère en phase externe a été mise au point. Pour cette étude, la nature de l'émulsionnant primaire puis le taux et la nature de l'émulsionnant secondaire ainsi que le pourcentage de l'émulsion primaire à disperser pour l'obtention de l'émulsion multiple, ont été optimisés. Le rôle de chacun de ces constituants a été envisagé dans la stabilisation de l'émulsion multiple ainsi que celui des différents additifs ultérieurement introduits. La différence de nature chimique entre les phases huileuses externe et interne et l'introduction de traceurs ont permis de suivre la stabilité de l'émulsion dans le temps et d'appréhender le mécanisme de libération de substances actives dans ce type de système, par dosages chromatographiques de l'acide oléique et de la vitamine E dans la paraffine liquide légère. Le taux de vitamine E libéré est inférieur à celui de l'acide oléique. Ce phénomène s'explique par une rétention de la vitamine E dans le réseau formé par les tensioactifs polymériques utilisés. La libération apparait done essentiellement provenir de l'éclatement des globules aqueux.Multiple emulsion of oil in water in

ISSN:0142-5463    

DOI:10.1111/j.1467-2494.1994.tb00077.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

SynopsisSemipermanent or direct colouring includes any product capable of affecting to some extent a change in the natural hair colour that will last through at least five shampoo washings. Semipermanent dyes are simple and easy to use, as opposed to oxidation dyes, and are normally formulated for application on nonbleached hair. Following increases in supply of such formulations, we have started an analysis for quality control purposes of 21 commonly marketed dyestuffs (nitroaminobenzenes, anthraquinone and Arianor dyes) and 20 colouring products manufactured by four leading companies. By using TLC (silica gel and reversed phase) and HPTLC (silica gel) procedures we have determined relative retention values to 1,3‐diamino‐4‐nitrobenzene of standards and dyes found in the commercial products. All the values reported (standards and samples) are the average of five analytical results (+

ISSN:0142-5463    

DOI:10.1111/j.1467-2494.1994.tb00078.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

SynopsisLead, arsenic and mercury in cosmetic formulations digested with HNO3+ HF (10:3) or HNO3+ H2SO4(5:1) in a microwave oven were determined, respectively, by the thin mercury film electrode, gold electrode and thin gold film electrode in sodium acetate buffer, in 6 m HNO3and 0.1 m HCIO4solution. Comparison with results obtained from atomic absorption spectrophotometric analysis (AAS) showed good agreement. The detection limits were 0.38 ppb (μgl‐1), 0.66ppb and 0.04ppb for lead, arsenic and mercury, respectively, using square wave anodic stripping voltammetry. The detection limits for lead, arsenic and mercury were 0.53 ppb, 1.24ppb and 0.40ppb, respectively, using AAS. The two methods proposed were applicable to the determination of concentrations at ppb levels of commercial cosmetic formulatio

ISSN:0142-5463    

DOI:10.1111/j.1467-2494.1994.tb00079.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

摘要:

SynopsisThe World Medical Association's Declaration of Helsinki outlines the principles for the conduct of drug and non‐drug clinical studies. The key difference between drug and non‐drug biomedical research is to be seen in the fact that for non‐drugs, the potential benefits, hazards and discomforts for the volunteer enrolled in a clinical study cannot be weighed against advantages of improving current diagnostic or therapeutic methods. The principles reflected in theGuidelines for Good Clinical Practice for Trials on Medicinal Products in the European Community, issued by the Commission of the European Communities in substantial parts also apply for trials on non‐medicinal products. Specifically this is true with regard to the requirements for the privacy, integrity, and well‐being of volunteers subjected to research, and fully informing them about the risks and benefits potentially associated with the use of a test product. Skin care products are the most prominent group of non‐drug products for which clinical studies are conducted. Using these products, the key differences between executing the principles in a non‐drug and a drug clinical study ar

ISSN:0142-5463    

DOI:10.1111/j.1467-2494.1994.tb00080.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY

ISSN:0142-5463    

DOI:10.1111/j.1467-2494.1994.tb00081.x

出版商:Blackwell Publishing Ltd    

年代:1994

数据来源: WILEY