摘要:

SUMMARYGrowth hormone (GH) cell auto‐antibodies have been demonstrated in the serum of a girl with an iso‐chromosome variant of Turner's syndrome. On two occasions she showed an abnormal response of GH release during insulin induced hypoglycaemia. Her response to GH treatment was poor, but this was commenced at a very late bone‐age. It is possible that autoimmunity is a new aetiological factor for GH deficiency in some

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1980.tb03126.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SUMMARYA 20–year‐old female presented with thyrotoxicosis associated with amenorrhoea and galactorrhoea after oral contraceptive withdrawal. Serum TSH was persistently elevated (mean: 28 ± 31 μU/ml during 24–h sampling and did not vary significantly after TRH, bromocriptine or somatostatin. Prolactin levels remained constantly at the upper limit of normal (mean: 206 ± 21 ng/ml, with a minimal increase after TRH, a slight decrease after somatostatin (54%) and a marked decrease after bromocriptine (885%). Surgical exploration revealed an unusually firm tumour adherant to the wall of the sella turcica; electron microscopic study showed that it was composed almost exclusively of thyrotrophs. After a transient period of euthyroidism post‐operatively, T3 toxicosis occurred with an increased TSH level (155 μU/ml) and a rise in TSH and alpha subunit in response to TRH. An increase in T4 followed while prolactin r

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1980.tb03127.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SUMMARYA gonadotrophin responsive testosterone producing adrenal cortical adenoma in a 61–year‐old woman is described. Oophorectomy was performed before adrenalectomy as at first an ovarian origin of excess androgen production was suspected. The hypophyseal gonadal feedback system was studied after oophorectomy using LHRH before and after administration of ethinyloestradiol. After adrenalectomy this study was repeated using ethinyloestradiol at two dose levels and after premedication with testosterone. In this patient the LH feedback system behaved similarly to that observed in Klinefelter's syndrome and in patients with anorc

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1980.tb03128.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SUMMARYThe changes in serum concentrations of thyroglobulin antibodies (TgAb) were investigated in eight patients with various thyroid disorders before, during and after thyroid surgery. TgAb was measured by a radioassay using 125I‐thyroglobulin.In six patients the TgAb decreased rapidly during operation. Of these patients, four had low concentrations pre‐operatively, and the decrease in TgAb resulted in undetectable concentrations for more than 2 days. Serum thyroglobulin (Tg), measured in the specimens with undetectable TgAb, i.e. immediately following surgery, showed concentrationvstime curves resembling curves from patients with no antibody present.Furthermore, two of these patients had such a high concentration of TgAb pre‐operatively that the initial Tg release was not sufficient to remove the TgAb, resulting in detectable TgAb throughout the investigation period. Serum samples drawn during and after operation were chromatographed according to molecular size, showing measureable Tg corresponding to 19S Tg. TgAb was only measureable in fractions corresponding to 7S IgG. The expected presence of complexed Tg and TgAb could not be demonstrated, but the analytical methods might have been unable to reveal this. The remaining two patients with thyroiditis showed no decrease in TgAb. This was compatible with a low content of Tg in the thyroid measured in one of

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1980.tb03129.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SUMMARYThe effect of dopamine on vasopressin release was studied by the infusion of L‐Dopa, a dopamine precursor that crosses the blood‐brain barrier. L‐Dopa suppressed resting levels of vasopressin and inhibited the rise of vasopressin produced by head‐up tilt. Carbidopa, a decarboxylase inhibitor that does not cross the blood‐brain barrier blocked the action of L‐Dopa. These results suggest that dopamine inhibits the release of vasopressin, either by an action at pituitary level or at the median eminence of the h

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1980.tb03130.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SUMMARYA 38–year‐old amenorrhoeic woman suffering from a prolactin (PRL) secreting adenoma, which had suprasellar extension as shown by carotid angiography and computed axial tomography (CAT), was treated with a dopamine agonist (lisuride). PRL levels were lowered and after 1 year of treatment CAT showed a marked reduction of the tumour size. After 2 years of treatment menstruation returned and CAT demonstrated a further reduction of the adenomatous tissue. This study supports the suggestion that dopamine agonists possess an anti‐pro‐liferative effect on tumoural lactotrophic cells of

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1980.tb03131.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SummaryThe prevalence of abnormal carbohydrate tolerance has been assessed in sixty‐nine acromegalic patients using six different criteria for the definition of diabetes mellitus. Family history, HLA status and the incidence of pancreatic islet cell antibodies have been documented and the effect of 3 months therapy with bromocriptine on oral glucose tolerance has been assessed in sixty‐one patients.Thirteen patients (18–8%) had clinical diabetes and a total of twenty‐six patients (377%) had asymptomatic diabetes as defined by the British Diabetic Association criteria of 1964. Implementing the 1978 recommendations of the British Diabetic Association, 130% were defined as diabetic. The incidence of a positive family history of diabetes was the same in the diabetic and non‐diabetic acromegalics. There was no disturbance in respect of any of the HLA antigens when this was considered for the number of specificities tested for, and no patient had pancreatic islet cell antibodies.On treatment with bromocriptine, there was a highly significant improvement in the glucose tolerance of both the diabetic (P<0.0001) and the non‐diabetic (P<0.005) acromegalics. However, in the group of eleven patients with no reduction of serum growth hormone on treatment, no improvement in glucose tolerance was seen.It is concluded that bromocriptine, by directly reducing serum growth hormone, has a significant effect on carbohydrate metabolism in acromegaly, irrespective of the initial level of glucos

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1980.tb03132.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SUMMARYrT3 metabolism in patients treated for thyrotoxicosis with propylthiouracil (PTU), or methimazole (MMI) was studied by infusion of rT3 and measurements of the increase in serum rT3 and serum 3, 3′‐diiodothyronine.The results indicate that the high serum rT3 observed during treatment with PTU is not due to an increase in rT3 production, but to a decrease in the metabolic clearance rate of rT3. rT3 infusion was followed by an increase in serum 3, 3′‐T2 which was similar whether PTU or MMI was given. However, after stopping rT3 infusion there was a more rapid fall in serum 3, 3′‐T2 during MMI treatment, compatible with an inhibitory effect of PTU on 3, 3′

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1980.tb03133.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SummaryTo investigate the origin of insulin in amniotic fluid amniocenteses were carried out in pregnancies with live, dead and anencephalic fetuses. Amniotic fluid insulin of pregnant women bearing live fetuses was 9.0 ± 2.1 μU/ml; in six women with dead foetuses amniotic fluid insulin was not detected. A significant positive correlation was observed between gestational age and the amniotic fluid concentration of insulin. In the amniotic fluid of the four women bearing anencephalic fetuses, the amount of hormone was within normal limits (10.0 ± 1.4 μU/ml). Intravenous glucose administration (0.33 g/kg body weight) to the mother does not influence levels of insulin in amniotic fluid, but brought about changes in amniotic fluid glucose concentration. These findings support the conclusion that human amniotic fluid insulin is of fetal rather than maternal ori

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1980.tb03134.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY

摘要:

SummaryIn an attempt to derive estimates of the incidence and prevalence of acromegaly a survey of the population in the area served by the former Newcastle Regional Hospital Board has been conducted to detect cases of acromegaly alive after 1 January 1960 and diagnosed before 31 December 1971. Cases were detected by means of letters to general practitioners, hospital physicians, neurosurgeons and to hospital records officers, as well as from death certificates. From the population of 3.1 millions a firm diagnosis of acromegaly was made in 164 patients, in eighty‐one on clinical grounds alone and in eighty‐three with confirmation by assay of human growth hormone (hGH). The annual incidence of acromegaly appears to be close to three cases per million and the prevalence of diagnosed cases up to forty cases per million. In male acromegalics there was a significant increase in the risk of death from cardiovascular, cerebrovascular, respiratory and malignant diseases but in females from cerebrovascular disease o

ISSN:0300-0664    

DOI:10.1111/j.1365-2265.1980.tb03135.x

出版商:Blackwell Publishing Ltd    

年代:1980

数据来源: WILEY